1.Heavy Hymenolepis nana Infection Possibly Through Organic Foods: Report of a Case.
Bong Jin KIM ; Kyung Seob SONG ; Hyun Hee KONG ; Hee Jae CHA ; Meesun OCK
The Korean Journal of Parasitology 2014;52(1):85-87
We encountered a patient with heavy Hymenolepis nana infection. The patient was a 44-year-old Korean man who had suffered from chronic hepatitis (type B) for 15 years. A large number of H. nana adult worms were found during colonoscopy that was performed as a part of routine health screening. The parasites were scattered throughout the colon, as well as in the terminal ileum, although the patient was immunocompetent. Based on this study, colonoscopy may be helpful for diagnosis of asymptomatic H. nana infections.
Adult
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Animals
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Colon/parasitology
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Colonoscopy
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Foodborne Diseases/*diagnosis/parasitology
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Humans
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Hymenolepiasis/*diagnosis
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Hymenolepis nana/*isolation & purification
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Ileum/parasitology
;
Male
2.Motor Function in School-Aged Children with Attention-Deficit/Hyperactivity Disorder in Korea.
Hyunjin CHO ; Seokyeon JI ; Sungho CHUNG ; Meesun KIM ; Yoo Sook JOUNG
Psychiatry Investigation 2014;11(3):223-227
OBJECTIVE: Motor function critically influences daily activities and academic performance. We compared motor function in school-aged children with Attention-Deficit/Hyperactivity Disorder (ADHD) to that of normal children. METHODS: Participants were 58 children with ADHD [51 males, 7 females; mean age 9 years 6 months+/-2 years 0 months (SD)] and 70 normal controls [56 males, 14 females; mean age 9 years 2 months+/-1 years 7 months (SD)]. We assessed motor function with the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition. RESULTS: The ADHD group had a significantly lower total motor composite score (t=-9.32, p<0.001) than that of the control group. Standard scores of four motor-area composites such as fine manual control (t=-3.76, p<0.001), manual coordination (t=-6.87, p<0.001), body coordination (t=-7.14, p<0.001), and strength and agility (t=-8.54, p<0.1) were significantly lower in the ADHD group than those in the control group. Among the subtests, scores on fine motor precision, fine motor integration, manual dexterity, bilateral coordination, balance, running speed and agility, and strength were significantly lower in the ADHD group than those in the controls, whereas upper-limb coordination was not significantly different between the groups. CONCLUSION: School-aged children with ADHD in Korea had significantly lower motor function compared to that of controls. Thus, it is suggested that appropriate target intervention for motor function is important in children with motor impairment in addition to pharmacotherapy or psychosocial therapy for improving the core symptoms.
Child*
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Drug Therapy
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Female
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Humans
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Korea
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Male
;
Running
3.Motor Function in School-Aged Children with Attention-Deficit/Hyperactivity Disorder in Korea.
Hyunjin CHO ; Seokyeon JI ; Sungho CHUNG ; Meesun KIM ; Yoo Sook JOUNG
Psychiatry Investigation 2014;11(3):223-227
OBJECTIVE: Motor function critically influences daily activities and academic performance. We compared motor function in school-aged children with Attention-Deficit/Hyperactivity Disorder (ADHD) to that of normal children. METHODS: Participants were 58 children with ADHD [51 males, 7 females; mean age 9 years 6 months+/-2 years 0 months (SD)] and 70 normal controls [56 males, 14 females; mean age 9 years 2 months+/-1 years 7 months (SD)]. We assessed motor function with the Bruininks-Oseretsky Test of Motor Proficiency, Second Edition. RESULTS: The ADHD group had a significantly lower total motor composite score (t=-9.32, p<0.001) than that of the control group. Standard scores of four motor-area composites such as fine manual control (t=-3.76, p<0.001), manual coordination (t=-6.87, p<0.001), body coordination (t=-7.14, p<0.001), and strength and agility (t=-8.54, p<0.1) were significantly lower in the ADHD group than those in the control group. Among the subtests, scores on fine motor precision, fine motor integration, manual dexterity, bilateral coordination, balance, running speed and agility, and strength were significantly lower in the ADHD group than those in the controls, whereas upper-limb coordination was not significantly different between the groups. CONCLUSION: School-aged children with ADHD in Korea had significantly lower motor function compared to that of controls. Thus, it is suggested that appropriate target intervention for motor function is important in children with motor impairment in addition to pharmacotherapy or psychosocial therapy for improving the core symptoms.
Child*
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Drug Therapy
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Female
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Humans
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Korea
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Male
;
Running
4.GASTric Cancer HER2 Re-Assessment Study 2 (GASTHER2): HER2 Re-assessment for Initially HER2-Negative Advanced Gastric Cancer Patients after Progression on First-Line Treatment
Jaewon HYUNG ; Hyung-Don KIM ; Min-Hee RYU ; Young Soo PARK ; Meesun MOON ; Yoon-Koo KANG
Cancer Research and Treatment 2024;56(1):199-207
Purpose:
Heterogeneous human epidermal growth factor receptor 2 (HER2) overexpression in gastric cancer may lead to a misdiagnosis of HER2 status. Accurate assessment of HER2 status is essential for optimal treatment as novel HER2-directed agents are being investigated in various clinical settings. We evaluated the usefulness of HER2 re-assessment following progression on first-line treatment in initially HER2-negative advanced gastric cancer (AGC) patients.
Materials and Methods:
We enrolled 177 patients with baseline HER2-negative AGC and performed HER2 re-assessment after progression on first-line treatment from February 2012 to June 2016 at Asan Medical Center, Seoul, Korea. The re-assessed HER2 status was analyzed with baseline HER2 status and clinical characteristics.
Results:
The median age was 54 years (range, 24 to 80 years), and 123 patients (69.5%) were men. Seven patients (4.0%) were HER2-positive on the re-assessment. Patients with baseline HER2 negativity confirmed by a single test (n=100) had a higher HER2-positive re-assessment rate compared to those who had repeated baseline testing (n=77) (5.0% vs. 2.6%). Among the patients with single baseline HER2 testing, the rate was higher in patients with baseline HER2 immunohistochemistry (IHC) 1+ compared to those with IHC 0 (13.4% vs. 3.6%).
Conclusion
Overall, 4.0% of patients with baseline HER2-negative AGC were HER2-positive on re-assessment, and the HER2-positive re-assessment rate was higher among patients who had a single test at baseline. HER2 re assessment may be considered for initially HER2-negative patients to determine their eligibility for HER2-directed therapy, particularly if their HER2 negativity was determined by a single test, especially if they had a single baseline HER2 IHC 1+ test.
5.Expression and Characterization of alpha-Methylacyl CoA Racemase from Anisakis simplex Larvae.
Bong Jin KIM ; Sun Mi KIM ; Min Kyung CHO ; Hak Sun YU ; Yong Seok LEE ; Hee Jae CHA ; Meesun OCK
The Korean Journal of Parasitology 2012;50(2):165-171
Larval excretory-secretory products of Anisakis simplex are known to cause allergic reactions in humans. A cDNA library of A. simplex 3rd-stage larvae (L3) was immunoscreened with polyclonal rabbit serum raised against A. simplex L3 excretory-secretory products to identify an antigen that elicits the immune response. One cDNA clone, designated as alpha-methylacyl CoA racemase (Amacr) contained a 1,412 bp cDNA transcript with a single open reading frame that encoded 418 amino acids. A. simplex Amacr showed a high degree of homology compared to Amacr orthologs from other species. Amacr mRNA was highly and constitutively expressed regardless of temperature (10-40degrees C) and time (24-48 hr). Immunohistochemical analysis revealed that Amacr was expressed mainly in the ventriculus of A. simplex larvae. The Amacr protein produced in large quantities from the ventriculus is probably responsible for many functions in the development and growth of A. simplex larvae.
Amino Acid Sequence
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Animals
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Anisakis/*enzymology/genetics
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Cloning, Molecular
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Cluster Analysis
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Gene Expression Profiling
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Gene Library
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Humans
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Immunohistochemistry
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Larva/enzymology/genetics
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Mice
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Mice, Inbred ICR
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Molecular Sequence Data
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Phylogeny
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Rabbits
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Racemases and Epimerases/genetics/*metabolism
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Sequence Homology, Amino Acid
6.Seroprevalence of Antibodies against Anisakis simplex Larvae among Health-Examined Residents in Three Hospitals of Southern Parts of Korea.
Jung KIM ; Jin Ok JO ; Seon Hee CHOI ; Min Kyoung CHO ; Hak Sun YU ; Hee Jae CHA ; Meesun OCK
The Korean Journal of Parasitology 2011;49(2):139-144
The present study was performed to estimate the seroprevalence of larval Anisakis simplex infection among the residents health-examined in 3 hospitals in southern parts of Korea. A total of 498 serum samples (1 serum per person) were collected in 3 hospitals in Busan Metropolitan city, Masan city, and Geoje city in Gyeongsangnam-do (Province) and were examined by IgE-ELISA and IgE-western blotting with larval A. simplex crude extract and excretory-secretory products (ESP). The prevalence of antibody positivity was 5.0% and 6.6% with ELISA against crude extracts and ESP, respectively. It was also revealed that infection occurred throughout all age groups and higher in females than in males. A specific protein band of 130 kDa was detected from 10 patients with western blot analysis against crude extract and ESP among those who showed positive results by ELISA. Our study showed for the first time the seroprevalence of anisakiasis in Korea. The allergen of 130 kDa can be a candidate for serologic diagnosis of anisakiasis.
Adolescent
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Adult
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Age Distribution
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Aged
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Aged, 80 and over
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Animals
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Anisakiasis/*epidemiology
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Anisakis/*immunology
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Antibodies, Helminth/*blood
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Antigens, Helminth/chemistry/diagnostic use
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Blotting, Western
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Child
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Enzyme-Linked Immunosorbent Assay
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Female
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Hospitals
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Humans
;
Immunoglobulin E/blood
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Korea/epidemiology
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Larva/immunology
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Male
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Middle Aged
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Molecular Weight
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Seroepidemiologic Studies
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Sex Distribution
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Young Adult
7.A Case of Furuncular Myiasis Due to Cordylobia anthropophaga in a Korean Traveler Returning from Uganda.
Su Min SONG ; Shin Woo KIM ; Youn Kyoung GOO ; Yeonchul HONG ; Meesun OCK ; Hee Jae CHA ; Dong Il CHUNG
The Korean Journal of Parasitology 2017;55(3):327-331
A fly larva was recovered from a boil-like lesion on the left leg of a 33-year-old male on 21 November 2016. He has worked in an endemic area of myiasis, Uganda, for 8 months and returned to Korea on 11 November 2016. The larva was identified as Cordylobia anthropophaga by morphological features, including the body shape, size, anterior end, posterior spiracles, and pattern of spines on the body. Subsequent 28S rRNA gene sequencing showed 99.9% similarity (916/917 bp) with the partial 28S rRNA gene of C. anthropophaga. This is the first imported case of furuncular myiasis caused by C. anthropophaga in a Korean overseas traveler.
Adult
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Diptera
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Genes, rRNA
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Humans
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Korea
;
Larva
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Leg
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Male
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Myiasis*
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Spine
;
Uganda*
8.A Case of Oral Myiasis Caused by Lucilia sericata (Diptera: Calliphoridae) in Korea.
Mun JANG ; Seung Min RYU ; Sang Chang KWON ; Jun Ouk HA ; Young Hoon KIM ; Dong Hyun KIM ; Soon Myung JUNG ; Soon Il LEE ; Woon Mok SOHN ; Hee Jae CHA ; Meesun OCK
The Korean Journal of Parasitology 2013;51(1):119-123
We report here a case of oral myiasis in the Republic of Korea. The patient was a 37-year-old man with a 30-year history of Becker's muscular dystrophy. He was intubated due to dyspnea 8 days prior to admission to an intensive care unit (ICU). A few hours after the ICU admission, 43 fly larvae were found during suction of the oral cavity. All maggots were identified as the third instars of Lucilia sericata (Diptera: Calliphoridae) by morphology. We discussed on the characteristics of myiasis acquired in Korea, including the infection risk and predisposing factors.
Adult
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Animals
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Diptera/anatomy & histology/*classification
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Humans
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Larva/anatomy & histology/classification
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Male
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Mouth/*parasitology
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Myiasis/*diagnosis/*parasitology
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Republic of Korea
9.Ten Cases of Taenia saginata Infection Confirmed by Analysis of the Internal Transcribed Spacer 1 rDNA Region in the Republic of Korea
Su Min SONG ; Hae Soo YUN ; Dorene VANBIK ; Hyun Ha CHANG ; Sang Ah LEE ; Shin Woo KIM ; Namhee RYOO ; Dong Yeub EUN ; Nan Young LEE ; Youn Kyoung GOO ; Yeonchul HONG ; Meesun OCK ; Hee Jae CHA ; Dong Il CHUNG
The Korean Journal of Parasitology 2019;57(4):417-422
From October 2015 to August 2018, tapeworm proglottids were obtained from 10 patients who were residents of Daegu and Gyeongbuk provinces and had a history of raw beef consumption. Most of them had no overseas travel experience. The gravid proglottids obtained from the 10 cases had 15–20 lateral uterine branches. A part of internal transcribed spacer 1 (ITS1) DNA of the 10 cases, amplified by polymerase chain reaction (PCR) and digested with AleI restriction enzyme, produced the same band pattern of Taenia saginata, which differentiated from T. asiatica and T. solium. Sequences of ITS1 and cytochrome c oxidase subunit 1 (cox1) showed higher homology to T. saginata than to T. asiatica and T. solium. Collectively, these 10 cases were identified as T. saginata human infections. As taeniasis is one of the important parasitic diseases in humans, it is necessary to maintain hygienic conditions during livestock farming to avoid public health concerns.
Agriculture
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Cestoda
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Daegu
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DNA
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DNA, Ribosomal
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Electron Transport Complex IV
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Gyeongsangbuk-do
;
Humans
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Livestock
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Parasitic Diseases
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Polymerase Chain Reaction
;
Public Health
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Red Meat
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Republic of Korea
;
Taenia saginata
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Taenia
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Taeniasis