1.A Case of Cutaneous Epithelioid Angiosarcoma.
Mee Ran LEE ; Young Ho WON ; Inn Ki CHUN
Korean Journal of Dermatology 1994;32(1):177-181
The epithelioid angiosarcoma is recently described ns a variant of ang-osarcoma based on its pathological feature, which is characterized by the epithelioid or histiocytoid morphology af the malignant tumor cells. The existence of vascular endothelial tumor with an epithelioid feature has been accepted for many years, most notablyn the forms of epithelioid hemangioma and epithelioid hemangioendo thelioma. In recent years, cutaneous angiosarcoma with epitheloid morphology have been reported as a cutaneos epithelioid angiosarcoma in the literatures. A 60-year-old man presente with a mild tender erythematous 2 x 2 x 2.5cm sized soft fluctuating single nodule with dark hemorrhagic crust on the left forehead for 3 months. He had had an abrasion wound on the lesion site of the forehead by an accidental trauma 5 month before the lesion appeared. Histopathological findings revealed that the tumor mass was chiefly composed of solid sheets of poorly differentiated malignant cells with an epithelioid feature. The characteristics of classical angiosarcoma such as primitive vascular spaces and clefts with malignat cells, and proliferating vessels were also found in some areas. The immunohistochemical stain wi.h the factor VIII related antigen ivas focally reactive in the tumor cells. Unfortunately he refused further treatment and expired 7 months after discharge at home without knowing the direct cause of his health. We report herein an interesting and rare case of the cutaneous epitheioid angiosarcoma which had typical clinical and histopathological findings and suggested as a case with a very aggressive course.
Forehead
;
Hemangioma
;
Hemangiosarcoma*
;
Humans
;
Middle Aged
;
von Willebrand Factor
;
Wounds and Injuries
2.CT Evaluation of Postoperative Neck Dissection.
Nam Joon LEE ; Jung Hyuk KIM ; Hwan Hoon CHUNG ; Mee Ran LEE
Journal of the Korean Radiological Society 1995;32(2):231-236
PURPOSE: To evaluate CT findings of normal anatomic alteration after neck dissection. MATERIALS AND METHODS: The postoperative CT findings were retrospectively reviewed in 40 patients with neck dissection, comparing to preoperative CT. There were 28 patients with radical neck dissection and 12 patients with modified radical neck dissection or selective neck dissection. In addition to the neck dissection, 10 patients had undergone pectoralis major myocutaneous flap reconstruction, 20 patients taken laryngectomy, and 25 patients treated with radiotherapy. RESULTS: The typical CT findings of radical neck dissection were non-visualization of internal jugular vein and sternocleidomastoid muscle(28/28), ipsilateral neck flattening(26/28), and trapezius muscular atrophy(12/28). The other non-specific findings were tissue plane eftacement, subcutaneous reticular pattern, platysma muscle thickening, and adjacent soft tissue contrast enhancement which was the only evidence of previous operation in the cases of modified radical neck dissection or selective neck dissection. Reconstruction with myocutaneous flap was shown as ipsilateral bulk of fat and muscle(10/10). In cases with radiation therapy there was much increased density of submandibular gland(12/25). 15 patients showed recurrence on follow up CT scan, including regional metastasis in 10, stomal recurrence in two, and residual mass at primary site in three patients. CONCLUSION: CT is useful in evaluation of patients with neck dissection and in whom postoperative change impese diagnostic problem.
Follow-Up Studies
;
Humans
;
Jugular Veins
;
Laryngectomy
;
Myocutaneous Flap
;
Neck Dissection*
;
Neck*
;
Neoplasm Metastasis
;
Radiotherapy
;
Recurrence
;
Retrospective Studies
;
Superficial Back Muscles
;
Tomography, X-Ray Computed
3.A Case of Rubinstein-Taybi Syndrome.
Won Hee BAIK ; Mee Ran ROH ; Young Chang KIM ; Hyung Jin CHOI ; Sang Jhoo LEE
Journal of the Korean Pediatric Society 1984;27(12):1244-1249
No abstract available.
Rubinstein-Taybi Syndrome*
4.Pleural Calcification as a Manifestation of Paragonimiasis: A Report of Two Cases.
Eun Young KANG ; Hae Young SEOL ; Yang Seok CHAE ; Mee Ran LEE
Journal of the Korean Radiological Society 1995;33(2):239-241
Pleural involvement in paragonimiasis is relatively common, either unilateral or bilateral, and may occur without pulmonary parenchymal infiltrates. Common radiologic findings of pleural paragonimiasis are pleural effusion, pneumothorax, hydropneumothorax, empyema and pleural thickening. However, pleural calcification as a manifestation of paragonimiasis is a rare condition. We report two cases of paragonimiasis manifested only as pleural calcifications which were confirmed pathologically.
Empyema
;
Hydropneumothorax
;
Paragonimiasis*
;
Pleural Effusion
;
Pneumothorax
5.A Case of Congenital Megacalyces.
Kyeong Mee LEE ; Ran Joo KIM ; Dae Yeol LEE
Journal of the Korean Pediatric Society 1997;40(6):883-886
Congenital megacalyces is a congenital renal disease characterized by hypoplasia of the medulla and a non-obstructive dilatation of the calyces. More than 100 cases have been reported in the literature after first described by Puigvert in 1963, but it has been reported only three cases (two cases of adults and one case of child) in the literatures in Korea. The etiology of the congenital megacalyces is unknown. Renal pelvis and ureter are mostly normal in size and there is no urinary obstruction or reflux. Renal medulla of congenital megacalyces is thinner than that of normal kidney but renal cortex retains its normal thickness and function. This is features that help to distinguish megacalyces from obstructive atropy. The calyces are polygonal in shape and the majority of kidney with megacalyces have increased number of calyces. Since congenital megacalyces is a non-progressive lesion, it is important to recognize the clinical entity and avoid unnecessary surgery. We report one case of congenital megacalyces without urinary obstruction or reflux with a brief review of related literatures.
Adult
;
Dilatation
;
Humans
;
Kidney
;
Kidney Pelvis
;
Korea
;
Unnecessary Procedures
;
Ureter
6.Tumoral Pseudoangiomatous Stromal Hyperplasia of Male Breast: A Case Report.
Sung Taek KIM ; Mee Ran LEE ; Hyang Im LEE
Journal of the Korean Society of Medical Ultrasound 2013;32(1):85-89
Tumoral form of pseudoangiomatous stromal hyperplasia (PASH) of male breast is a rare disease entity. We report on a case of PASH that presented as a palpable subareolar breast mass in a 46-year-old male who has been on hemodialysis due to chronic renal failure. To the best of our knowledge, no case of PASH in a male with chronic renal failure has yet been reported. We describe its mammographic and sonographic findings with correlative histopathologic features, confirmed by surgical excision.
Angiomatosis
;
Breast
;
Breast Diseases
;
Humans
;
Hyperplasia
;
Kidney Failure, Chronic
;
Male
;
Rare Diseases
;
Renal Dialysis
7.Effect of Pentoxifylline on Liver Fibrosis and Cell Cycle Related Proteins in Thioacetamide-Induced Rat Cirrhosis.
Kee Taek JANG ; Mee Suk LEE ; In Pyung JUNG ; Mee Ran KIM ; Ja June JANG
The Korean Journal of Hepatology 2001;7(3):281-291
Background: Thioacetamide is a classic hepatotoxic reagent which leads to the reproducible hepatic fibrosis in rats. Thioacetamide-induced fibrosis is an appropriate model for cirrhosis in humans due to the long duration of course and similiar histology. Thioacetamide produces hepatotoxicity through lipid peroxidation but it is unclear whether lipid peroxidation directly correlated with hepatic fibrosis. Pentoxifylline, a derivative of the methylxanthine, showed an antifibrogenic effect in cell cultures of human fibroblasts and some animal models. But this antifibrogenic effect is controversial. Pentoxifylline revealed a hepatoprotective effect in some toxic hepatitis. This hepatoprotective effect seems to influence cell cycle regulatory protein during regeneration. This study aimed to evaluate an effect of pentoxifylline on fibrosis and cell cycle regulatory protein during liver regeneration in thioacetamide-induced rat cirrhosis. Lipid peroxidation assay was compared with collagen content so as to evaluate the correlation with fibrosis. METHOD: Liver cirrhosis was induced by 0.03% oral administration of thioacetamide. Pentoxifylline was administered simultaneously with thioacetamide. The semiquantitative fibrosis index was measured based on histologic finding. Collagen content was estimated by spectrophotometric assay. Activated hepatic stellate cells were counted using alpha-SMA immunohistochemistry. Malondialdehyde, lipid peroxidation metabolite, was estimated by thiobarbituric acid reactive substance assay. Cell cycle regulatory protein was evaluated by western blot. RESULTS: There was no difference in semiquantitative fibrosis index, collagen content and hepatic stellate cell count between thioacetamide treated rats and simultaneous pentoxifylline treated rats. Lipid peroxidation product was not correlated with collagen content. Western blot showed no difference in cell cycle regulatory protein. CONCLUSION: Pentoxifylline does not show an antifibrogenic effect in thioacetamide-induced rat cirrhosis, in which thioacetamide induced hepatocellular damage and fibrosis. Lipid peroxidation may be a secondary effect rather than primary mediating mechanism in hepatic fibrosis.
Administration, Oral
;
Animals
;
Blotting, Western
;
Cell Culture Techniques
;
Cell Cycle*
;
Collagen
;
Drug-Induced Liver Injury
;
Fibroblasts
;
Fibrosis*
;
Hepatic Stellate Cells
;
Humans
;
Immunohistochemistry
;
Lipid Peroxidation
;
Liver Cirrhosis*
;
Liver Regeneration
;
Liver*
;
Malondialdehyde
;
Models, Animal
;
Negotiating
;
Pentoxifylline*
;
Rats*
;
Regeneration
;
Thioacetamide
8.Percutaneous Abscess Drainage of Multiloculated Liver Abscess.
IN Ho CHA ; Jung Hyuk KIM ; Yun Hwan KIM ; Min Cheol OH ; Cheol Joong KIM ; Whan Hoon JUNG ; Mee Ran RAN LEE
Journal of the Korean Radiological Society 1994;30(5):811-815
PURPOSE: Recently there have been some reports that percutaneous absces drainage(PAD) was ineffective in treating multiloculated liver abscess. We therefae, reviewed our results of catheter drainage in jultiloculated liver absces. MATERIALS AND METHODS: PADs in 10 cases of multiloculated liver abscesses were performed with 8.5F Pig tail, 12 & 14F Sump cahteters, under ultrasonic & fluoroscopic guidance. RESULTS: All the 10 cases were successfully drained without major complications. Mean drainage duration was 16.3 day and the result was not significantly different from those obtained by draining unilocular pyogenic liver abscess. The success was the result of using large caliber catheter and repetition in insertion of guidewire deeply into abscess cavity to make communications between the Iocules which was proven by abscessogram. CONCLUSION: PAD was safe and effective method for multiloculated abscess as unilocular liver abscess, and it is recommended that the multiloculated liver abscess be draincd.
Abscess*
;
Catheters
;
Drainage*
;
Liver Abscess*
;
Liver Abscess, Pyogenic
;
Liver*
;
Ultrasonics
9.Primary Cutaneous Aspergillosis in Leukemic Children.
Jin Young PARK ; Mee Ran KIM ; Hee Young SHIN ; Hoan Jong LEE ; Hyo Seop AHN ; Je Geun CHI
Journal of the Korean Pediatric Society 1994;37(4):520-526
Primary cutaneous aspergillosis is rare. In this report we describe primary skin infection by Aspergillus in 9 children with leukemia. The skin lesion was characterized clinically by erythematous macule and papule associated with pain and itching, followed by a rapid progression to ulcer and central black eschars with raised erythematous border at the site of venipuncture, insertion of intravenous cannula, or where arm boards had been taped to extremities. Diagnosis was confirmed by skin biopsy and wound culture. Positive revealed in 6 patients, including A. glaucus in 2 cases, A. flavus in 1 case. Treatment consisted of temporary withdrawl of anticancer chemotherapy, intravenous amphotericin B, oral flucytosine, itraconazole and/or rifampin. One patient recovered completely without antifungal medication with resolution of leukopenia. Six of eight treated patients recovered. One patient discharged against medical advice, while cutaneous aspergillosis was improving. One patient died with persistent skin lesion and neutropenia. We conclude that primary cutaneous aspergillosis is increasingly recognized in association with intravenous cannula, intravenous puncture or prolonged contact with arm boards in immunocompromised patients, and that this serious disease can be treated successfully with appropriate management.
Amphotericin B
;
Arm
;
Aspergillosis*
;
Aspergillus
;
Biopsy
;
Catheters
;
Child*
;
Diagnosis
;
Drug Therapy
;
Extremities
;
Flucytosine
;
Humans
;
Immunocompromised Host
;
Itraconazole
;
Leukemia
;
Leukopenia
;
Neutropenia
;
Phlebotomy
;
Pruritus
;
Punctures
;
Rifampin
;
Skin
;
Ulcer
;
Wounds and Injuries
10.Computerization of Surgical Pathology Reporting by Personal Computer.
Dong Sug KIM ; Young Ran SHIM ; Mee Jin KIM ; Hae Joo NAM ; Won Hee CHOI ; Tae Sook LEE
Korean Journal of Pathology 1992;26(2):146-153
The authors have been developed a menu-driven FoxBASE system for surgical pathology reporting and automatic encoding in Systematized Nomenclature of Medicine. The system requires no prior knowledge of FoxBASE and is readily installed on any IBM or it's compatible personal computer. Working sheet generation is automatically accompanied by data from previous cases on the same patient. Important data which include patient name, age, sex, surgical number, hospital unit number and encoded diagnoses, are stored on the hard disk permanently; complete reports are saved on floppy diskettes. Cases can be retrieved by patient name, surgical number, hospital unit number and SNOMED codes within 0.1 second. Daily work lists and listings of incomplete cases are easily obtained. This FoxBASE system has been in use for 1 year and 6 months and resulted in increased efficiency of retrieval and gathering of basic information for specific study, cost effectiveness, markedly diminished workload of typist and very short wasting time during complete restoration of data file for hard disk failure.