No abstract available.
Diagnosis* ; Infant, Newborn ; Meconium Aspiration Syndrome* ; Meconium*

The congenital renal cystic disease encompasses a complex group of pathologic and clinical entities. We retrospectively reviewed 42 cases of congenital renal cystic lesions classified into four Potter types in a series of 2,063 consecutive autopsies from 1981 to 1996. According to our study based on morphologic, clinical, genetic features and associated anomalies, type I and III are relatively compatible with Potter's original definition. However, it was reasonable that type II and IV are classified to the same group because of: 1) very similar histologic findings representing dysplastic kidney, 2) many associated anomalies, 3) no evidence of inheritance, and 4) presence of a combined type. Syndrome associated cysts, such as Meckel-Gruber syndrome, were also separately classified. If the dysplastic evidence was insufficient for diagnosis to the dysplastic kidney in type II and IV, then these cases would be better classified into a cystic disease associated with congenital hydronephrosis. We propose a classification of the congenital cystic disease of the kidney to be: 1) dysplastic kidney, 2) cystic disease associated with congenital hydronephrosis, 3) polycystic kidney, and 4) syndromic cystic disease.
Autopsy ; Classification* ; Diagnosis ; Hydronephrosis ; Kidney* ; Polycystic Kidney Diseases ; Retrospective Studies ; Wills

No abstract available.
Hypothyroidism* ; Thyroid Gland*

No abstract available.
Hypothyroidism* ; Thyroid Gland*

No abstract available.
alpha-Fetoproteins* ; Infant, Newborn ; Jaundice, Neonatal* ; Plasma*

PURPOSE: To analyze the fitting characteristics of contact lens, according to the clinical findings keratoconus of in Koreans. METHODS: The topographic indices were evaluated in 106 keratoconic eyes of the 53 patients, who had been followed up for at least 1 month, and their fitting pattern parameters retrospectively analyzed. The visual acuity, epithelial erosion, glare, daily lens wearing time, pain and the changes in the topographic indices were evaluated after fitting. RESULTS: The number of eyes fitted with spherical RGP, aspherical RGP and multicurve RGP were 19, 6 and 81 eyes with mean base curve radius (BCR) of 7.67, 7.17, and 6.76 mm, respectively. The Sim K and temporal K 3 mm from the center were significantly correlated with the BCR. 77 eyes achieved visual acuity of 20/30 or better, and the mean daily wearing time was 11.6 hours. Glare and pain were reported in 4 and 7 eyes, respectively, and progression of epithelial erosion was found in 8 eyes. The mean anterior elevation and sim Kmax in lens intolerable eyes were 0.0745 mm and 59.35 D, which were significantly higher than 0.0584 mm and 54.22 D in lens tolerable eyes. No progressive keratoconic changes were observed in the topographic indices for the eyes fitted with the multicurve lenses. CONCLUSIONS: Appropriate fitting guide-lines could be established by analyzing the fitting and clinical characteristics in keratoconus.
Glare ; Humans ; Keratoconus* ; Radius ; Retrospective Studies ; Visual Acuity

Benign and malignant papillary neoplasms of the breast may be difficult to distinguish in both cytologic and histologic preparations. To define the cytologic features of benign and malignant papillary lesions, we retrospectively reviewed 18 cases of fine needle aspirates from histologically confirmed cases of papilloma or papillary carcinoma of the breast. This study included 3 intraductal papillary carcinomas, 3 invasive papillary carcinomas, and 12 intraductal papillomas. All cases were evaluated for presence or absence of papillary fragments, bloody background, apocrine metaplasia, macrophages, and degree of cellularity, atypia, and single isolated columnar epithelial cells. Papillary fragments were present in all cases. The background of the smear was bloody in all 6 carcinomas, but in only 7 out of 12 papillomas. Markedly increased cellularity was present in 4 carcinomas (67%) and 7 papillomas (58%). Single cells were present in 5 carcinomas (83%) and 8 papillomas (67%). The majority of papillomas and papillary carcinomas had mild to moderate atypia, and severe atypia was noted in one case of intraductal papillary carcinoma and one case of invasive papillary carcinoma. Apocrine metaplasia was absent in all cases of papillary carcinomas, but present in 8 papillomas (67%). Macrophages were noted in 4 carcinomas and were present in all cases of papillomas. The constellation of severe atypia, bloody background, absence of apocrine metaplasia and/or macrophages were features to favor carcinoma. Malignant lesions tended to show higher cellularity and more single isolated cells. The cytologic features mentioned above would be helpful to distinguish benign from malignant papillary lesions of the breast. However, because of overlapping of cytologic features, surgical excision should be warranted in all cases of papillary lesions of the breast to further characterize the tumor
Breast ; Carcinoma, Papillary ; Central Nervous System* ; Cyclosporine* ; Epithelial Cells ; Macrophages ; Metaplasia ; Needles ; Papilloma ; Papilloma, Intraductal ; Retrospective Studies

No abstract available.
Acyclovir* ; Necrosis*

No abstract available.
Family Practice* ; Humans

Brachycephaly is a kind of craniosynostosis. Because of premature closure of the coronal suture, the skull is shorter in the anteroposterior diameter but is widened with a high vault and the occiput and forehead are flattened. Diabetes insipidus had been reported in oxycephaly. We have experienced a case of central diabetes insipidus associated with brachycephaly. A brief review of related literatures is included in this report.
Craniosynostoses* ; Diabetes Insipidus ; Diabetes Insipidus, Neurogenic* ; Forehead ; Skull ; Sutures