1.Correlation of the Intestinal Metaplasia Subtypes and Gastric Carcinoma.
Hwa Eun OH ; Mee Ja PARK ; Jong Sang CHOI
Korean Journal of Pathology 1997;31(12):1272-1281
Helicobacter pylori, loss of basement membrane, atrophy, type III intestinal metaplasia, adenomatous polyposis coli (APC) gene mutations and altered p53 function were believed as a factor to develop the gastric adenocarcinomas. To investigate the incidence and prevalence of Helicobacter pylori, intestinal metaplasia and atrophy, 120 gastrectomy specimens collected from patients with gastric adenocarcinoma (100 cases) and non-neoplastic conditions (20 cases) were studied. Intestinal metaplasia can be classified as type I (complete), type II (incomplete, sulfomucin-negative) and type III (incomplete, sulfomucin-positive) by Filipe and Jass. The incidence of intestinal metaplasia of gastric adenocarcinoma was 96% compared with the incidence of 75% in non-neoplastic conditions. The type I and type II were more common than type III and were present in both non-neoplastic conditions (75%) and adenocarcinoma (74%). In contrast, type III intestinal metaplasia was seen in only 20% of intestinal metaplasia-positive cases, all of which (22 of 22) were from patients with adenocarcinoma. The high specificity of type III intestinal metaplasia might be acceptable for screening purposes, but its sensitivity of 22% for gastric adenocarcinoma is low. Helicobacter pylori were detected in 96% of adenocarcinoma cases and 100% of non-neoplastic cases. Atrophy was detected in 50% of non-neoplastic cases and in 57% of adenocarcinoma cases. The data thus confirms a significant relation between incomplete sulfomucin-secreting intestinal metaplasia (type III) and gastric carcinoma, especially intestinal type (p<0.01). Thus, the type III intestinal metaplasia should be considered a risk factor and its presence in a biopsy specimen should prompt close surveillance.
Adenocarcinoma
;
Adenomatous Polyposis Coli
;
Atrophy
;
Basement Membrane
;
Biopsy
;
Gastrectomy
;
Helicobacter pylori
;
Humans
;
Incidence
;
Mass Screening
;
Metaplasia*
;
Prevalence
;
Risk Factors
;
Sensitivity and Specificity
2.Clinical Application of EMA, CEA and LCA in Differential Diagnosis of Tumors.
Mee Ja PARK ; Insun KIM ; Seung Yong PAIK
Korean Journal of Pathology 1985;19(2):168-178
To determine the therapeutic plan and to predict the prognosis, it is a pivotal and important task to differentiate the exact nature of the various undifferentiated neoplasms. In order to solve this problem, the electron microscopy has once been considered only method in certain cases. Recently, however, the immunoperoxidase staining method which is less expensive and easier to usethan electron microscopy has been developed and introduced. To evaluate the diagnostic value of epithelial membrane antigen(EMA), carcinoembryonic antigen(CEA) and leukocyte common antigen(LCA) immunoperoxidase method, the authors applied these staining in 15 cases of which exact diagnoses were difficult with conventional routine and special stains, using the formalin-fixed and paraffin-embedded tissue sections. The results are as follows: 1) EMA was helpful in confirming the diagnosis or revising to the proper diagnosis of undifferentiated carcinoma in 4 of 6 cases and in excluding the possibility of hepatocellular carcinoma and melanoma in 2 cases, respectively. The negative stainabilities in one case of choriocarcinoma and one case of malignant fibrous histiocytoma was useful to exclude the possibility of squamous cell carcinoma and the positive stainability in one case of giant cell carcinoma to exclude the possibility of sarcoma. 2) The diagnostic value of CEA was similar to that of EMA; CEA was useful to differentiate from malignant lymphoma in one case of epithelial tumor in which CEA was positive and EMA negative. 3) LCA was useful to differentiate one case of malignant lymphoma from undifferentiated carcinoma and to confirm Ewing's sarcoma from malignant lymphoma in one case.
Diagnosis, Differential
;
Carcinoma, Hepatocellular
3.Aromatherapy in primary care.
Jong Cheol KIM ; Mee Aue PARK ; Myung Ja KIM
Journal of the Korean Academy of Family Medicine 2002;23(4):417-429
No abstract available.
Aromatherapy*
;
Primary Health Care*
4.A case of multiple endobronchial hamartomas.
Sung Kyu PARK ; Kyoung Joo RHEE ; Mee Ja PARK ; Sun Young KIM
Tuberculosis and Respiratory Diseases 1992;39(1):83-88
No abstract available.
Hamartoma*
5.The Significance of Cervical Erosion with Benign Cellular Change on Papanicolaou Smear.
Mee Jeong JOENG ; Kum Ja PARK ; Kook Young YOO
Korean Journal of Obstetrics and Gynecology 1997;40(10):2241-2245
The significance of cervical erosion with benign cellular change on Papanicolaou smear has not been evaluated. A retrospective review of 430 coloscopically directed punch biopsies performed over 15 months revealed 206 cases who had a benign cellular change on cytologic smear. Of these 206 smears, 48(23%) had clear cervix without erosion, 99(48%) had mild erosion on cervix, 41(20%) had moderate cervical erosion and 18(9%) had severe cervical erosion. The false negative rate that revealed more than mild dysplasia on histologic diagnosis was 2% in patients without cervical erosion, 3% in patients with mild cervical erosion, 5 % in patients with moderate cervical erosion, and 11% in patients with severe cervical er- osion. Koilocytotic change that suggested human papilloma virus infection was 17% in each group regardless cervical erosion. In conclusion, benign cellular change on Pap smears in patients with severe cervical erosion may be associated with significant cervical cancer pathology.
Biopsy
;
Cervix Uteri
;
Diagnosis
;
Female
;
Humans
;
Papanicolaou Test*
;
Papilloma
;
Pathology
;
Retrospective Studies
;
Uterine Cervical Neoplasms
7.A case of Sertoli-Leydig cell tumor.
Mi Ja LEE ; Kyoung Suk PARK ; Hee Soo CHUNG ; Hyang Mee KIM ; Eun Hee YOO ; Jung Ja AHN
Korean Journal of Obstetrics and Gynecology 1992;35(4):618-623
No abstract available.
Sertoli-Leydig Cell Tumor*
8.The Frequency and Distribution of the ABO Subgroups in Korean Blood Donors.
Ja Young LEE ; Deok Ja OH ; Yoon Mee PARK
Korean Journal of Blood Transfusion 2010;21(3):223-229
BACKGROUND: ABO subgroups are obstacles in blood typing and cross matching in the process of pre-transfusion. Correct ABO typing is important for ensuring safety of a transfusion. The ABO subgroups contain a lesser amount of antigen on red cells and this is a common cause of discrepancy between the results of cell and serum tests. This study was performed to analyze the frequency and distribution of the ABO subgroups in Korean blood donors. METHODS: ABO blood grouping was performed by an automated analyzer (PK7200/7300, Olympus, Japan) for the 3,397,983 donors from January 2007 to December 2009. The 1,868 donor samples that were suspected to have ABO subgroups were tested with adsorption/elution techniques. The results of the tests were analyzed and we received approval of the Institutional Review Board of the Korean Red Cross to publish this study. RESULTS: 1,771 donors out of the 1,868 donors who underwent the tests were finally identified as having ABO subgroups. The kinds of identified ABO subgroups were as follows; 118 donors with the A subgroup (A2, A3, Ax, Am, Ael), 237 donors with the B subgroup (B3, Bx, Bm, Bel) and 1,416 donors with the AB subgroup (A2B, A2B3, A1B3, AmB, A1Bm, A1Bel, AxB, A1Bx). The most frequently observed subgroups were A2B (496/1,868, 26.55%) and then A2B3 (457/1,868, 24.46%). The subgroups of 97 donors (5.19%) were not identified. CONCLUSION: This study was meaningful to provide data on the frequency and distribution of the ABO subgroups of Korean blood donors. A more sensitive technique such as genotyping could be useful to resolve cases with an unidentified subgroup.
Blood Donors
;
Blood Grouping and Crossmatching
;
Ethics Committees, Research
;
Humans
;
Red Cross
;
Tissue Donors
9.Nutritional and Health Status of Korean Elderly from Low-income, Urban Area and Improving Effect of Meal Service on Nutritional and Health Status - V. The Effect of Meal Service for One Year on Nutritional and Health Status.
Sook Mee SON ; Yaung ja PARK ; Jae Ok KOO ; Yoon Na LEE ; Hye Young YOON
Korean Journal of Community Nutrition 1997;2(1):63-73
This study was performed to assess the effect of one year's of meal service for home-staying urban elderly with low incole on their nutritional status. One hundred and eighty three subjects, who had already completed the first nutritional survey, were assigned to two group : meal served(served) and non-meal served(non-served). A meal containing approximately on half of the RDA for energy, protein, calcium and iron was served as lunch everyday to served group. After on year of meal service, follow-up-nutritional survey was done and changes of parameters were analyzed with paired t-test. Served female showed signficantly increased intake of riboflavin and calcium, while non-served female showed significantly decreased intake of calcium. Serum total protein, serum albumin and serum cholesterol were significantly increased in female regardless of meal service. Served remale was observed with significantly elevated LDL-cholesterol, whereas non-served female showed singnificantly lowered HDL-cholesterol. Significantly decreased serum iron, serum transferrin saturaion and significantly increased TIBC were observed for female regardless of meal service. But the proportion of anemic elderly according to Hb or serum iron was decreased more in served group. Female showed significantly increased serum zinc and copper regardless of meal service, whereas only served male showed significantly increased serum copper.
Aged*
;
Calcium
;
Cholesterol
;
Copper
;
Female
;
Humans
;
Iron
;
Lunch
;
Male
;
Meals*
;
Nutrition Surveys
;
Nutritional Status
;
Riboflavin
;
Serum Albumin
;
Transferrin
;
Zinc
10.Incidentally Founded Biphasic Pulmonary Blastoma.
Nam Hoon KIM ; Dong oon KEUM ; Joo Heon KIM ; Mee Ja PARK
Tuberculosis and Respiratory Diseases 2001;50(5):641-644
Pulmonary blastoma is a family of tumors in which the glands or mesenchyme composing the neoplasm are primitive or embryonic in appearance. There are three subtypes, which include well differentiated fetal adenocarcinoma (pulmonary endodermal tumor), biphasic pulmonary blastoma, and cystic and pleuropulmonary blastomas in children. Among them, biphasic pulmonary blastoma is a primary malignancy of the lung originating from multipotential pulmonary blastema including both the malignant fetal epithelial and mesenchymal components. These make up 0.25 to 0.5 percent of all primary malignant lung tumors. This tumor is usually symptomatic and appears as a large, solitary peripheral mass, with a tendency to favor the upper lobe. Here we report a case where small sized asymptomatic peripheral lung mass was diagnosed as a biphasic pulmonary blastoma, prior to the operation, A subsequent percutaneous needle biopsy was performed, which revealed features of a large cell neuroendocirne tumor. In addition, a review of the relevant literature is provided.
Adenocarcinoma
;
Biopsy, Needle
;
Child
;
Endoderm
;
Humans
;
Lung
;
Mesoderm
;
Pulmonary Blastoma*