1.Medulloblastoma in Adult: 2 Cases Report.
Choong Kyum PARK ; Sang Ho LEE ; Jong Woong DOH ; Young Soo KIM
Journal of Korean Neurosurgical Society 1979;8(2):583-588
The medulloblastoma is a tumor of the cerebellum, particulary common in children. Most of them in childhood are situated in the midline vermis, but in adults are in the lateral lobes. The authors reported two cases of medulloblastoma which developed in the midline vermis although the patients were adult, and reviewed with concerned articles.
Adult*
;
Cerebellum
;
Child
;
Humans
;
Medulloblastoma*
2.Radiation-Induced Glioma In a Child.
Chul LEE ; Chang Jin KIM ; Yang KWON ; Seung Chul RHIM ; Jung Kyo LEE ; Duk KWUN ; C Jin WHANG
Journal of Korean Neurosurgical Society 1993;22(11):1256-1264
A case of cerebral glioma which was developed 5 years after brain irradiation for medulloblastoma is reported. The etiology and pathogenesis of human glioma are still unknown. The possible causal role of radiation therapy in inducing cerebral glioma is discussed on the basis of these observations.
Brain
;
Child*
;
Glioma*
;
Humans
;
Medulloblastoma
3.Imaging Findings of Atypical Teratoid/Rhabdoid Tumor of Infancy & Childhood in CNS: Report of Two Cases.
Hee Jung SHIN ; Dong Woo PARK ; Seung Roh LEE ; Chang Kok HAHM ; Eun Kyung HONG
Journal of the Korean Radiological Society 2001;44(5):629-632
Atypical teratoid/rhabdoid tumor rarely occurs in the CNS, though is most common in infants under two years of age. It is characterized by unique histologic features, has an extremely aggressive natural course, and is located mainly in the infratentorial region. Radiologically, it is difficult to distinguish from primitive neuroectodermal tumor or medulloblastoma. We report the radiologic findings of two cases of atypical teratoid/rhabdoid tumor.
Humans
;
Infant
;
Medulloblastoma
;
Neuroectodermal Tumors, Primitive
4.Medulloblastoma with Extracranial Metastates: Case Report.
In Soo BYUN ; Hyuk In CHUNG ; Jung Kil RHEE ; In Hong KIM
Journal of Korean Neurosurgical Society 1977;6(2):567-572
Intracranial tumor with extracranial metastasis has been seldom reported. A 28 year-old-male was admitted to Presbyterian Hospital in Daegu on May 9, 1977. Who was diagnosed to have a medulloblastoma in the right cerebellar hemisphere with metastases to the right axillary lymphnode and head of pancreas by pathological reports. In generally medulloblastoma with extracranial metastasis occurs very rarely in the cerebellar hemisphere, and especially in adulthood. Distant metastasis of the intracranial tumor is discussed with review of the literatures.
Daegu
;
Head
;
Medulloblastoma*
;
Neoplasm Metastasis
;
Pancreas
;
Protestantism
6.Sudden Unexpected Death Due to Medulloblastoma.
Seong Ho KIM ; Tae Gong KIM ; In Soo SEO ; Hyun Mu KANG ; Young Shik CHOI
Korean Journal of Legal Medicine 2009;33(2):130-132
The majority of deaths due to intracranial tumors are preceded by long periods of symptoms, resulting in diagnosis of the tumors. And introduction of CT and MRI have led to increased early detection of intracranial tumors. Nonetheless, sudden unexpected deaths from intracranial tumors are rarely encountered at autopsy. We report an autopsy case of 2-year-old boy who died from medulloblastoma.
Autopsy
;
Brain Neoplasms
;
Death, Sudden
;
Medulloblastoma
;
Preschool Child
7.Analysis of the Causes of Subfrontal Recurrence in Medulloblastoma and Its Salvage Treatment.
Jae Ho CHO ; Woong Sub KOOM ; Chang Geol LEE ; Kyoung Ju KIM ; Su Jung SHIM ; Jino BAK ; Kyoungkeun JEONG ; Tae Gon KIM ; Dong Seok KIM ; Joong Uhn CHOI ; Chang Ok SUH
The Journal of the Korean Society for Therapeutic Radiology and Oncology 2004;22(3):165-176
PURPOSE: Firstly, to analyze factors in terms of radiation treatment that might potentially cause subfrontal relapse in two patients who had been treated by craniospinal irradiation (CSI) for medulloblastoma. Secondly, to explore an effective salvage treatment for these relapses. MATERIALS AND METHODS: Two patients who had high-risk disease (T3bM1, T3bM3) were treated with combined chemoradiotherapy. CT-simulation based radiation-treatment planning (RTP) was performed. One patient who experienced relapse at 16 months after CSI was treated with salvage surgery followed by a 30.6 Gy IMRT (intensity modulated radiotherapy). The other patient whose tumor relapsed at 12 months after CSI was treated by surgery alone for the recurrence. To investigate factors that might potentially cause subfrontal relapse, we evaluated thoroughly the charts and treatment planning process including portal films, and tried to find out a method to give help for placing blocks appropriately between subfrotal-cribrifrom plate region and both eyes. To salvage subfrontal relapse in a patient, re-irradiation was planned after subtotal tumor removal. We have decided to treat this patient with IMRT because of the proximity of critical normal tissues and large burden of re-irradiation. With seven beam directions, the prescribed mean dose to PTV was 30.6 Gy (1.8 Gy fraction) and the doses to the optic nerves and eyes were limited to 25 Gy and 10 Gy, respectively. RESULTS: Review of radiotherapy portals clearly indicated that the subfrontal-cribriform plate region was excluded from the therapy beam by eye blocks in both cases, resulting in cold spot within the target volume. When the whole brain was rendered in 3-D after organ drawing in each slice, it was easier to judge appropriateness of the blocks in port film. IMRT planning showed excellent dose distributions (Mean doses to PTV, right and left optic nerves, right and left eyes: 31.1 Gy, 14.7 Gy, 13.9 Gy, 6.9 Gy, and 5.5 Gy, respectively. Maximum dose to PTV: 36 Gy). The patient who received IMRT is still alive with no evidence of recurrence and any neurologic complications for 1 year. CONCLUSION: To prevent recurrence of medulloblastoma in subfrontal-cribriform plate region, we need to pay close attention to the placement of eye blocks during the treatment. Once subfrontal recurrence has happened, IMRT may be a good choice for re-irradiation as a salvage treatment to maximize the differences of dose distributions between the normal tissues and target volume.
Brain
;
Chemoradiotherapy
;
Craniospinal Irradiation
;
Humans
;
Medulloblastoma*
;
Optic Nerve
;
Radiotherapy
;
Recurrence*
8.A Case of Transitional Medulloblastoma in the Posterior Fossa of a Child.
Yong Tai KIM ; Hae Dong JHO ; Yung Rak YOO ; Nam Kyu KIM ; Hwan Yung CHUNG
Journal of Korean Neurosurgical Society 1980;9(2):523-528
The case is reported of a 2 1/2-year-old femal with headache, vomiting and paraparesis. Clinical feature and operative findings are quite different from those of classic medulloblastoma in its lateral location, well-circumscribed tendency, non-invasiveness, no CSF metastasis, and favourable prognosis after surgical removal. Histological features are the combination of those of classic, and desmoplastic medulloblastoma. Review of literature was done.
Child*
;
Headache
;
Humans
;
Medulloblastoma*
;
Neoplasm Metastasis
;
Paraparesis
;
Prognosis
;
Vomiting
9.Premature Reversal Caloric Nystagmus in a Patient withMedulloblastoma, Originated from the 4th Ventricle.
Hyung LEE ; Jang Joon LEE ; Sang Sub JANG ; Seung Hwan LEE ; Jeong Geun LIM ; Sang Doe YI ; Young Choon PARK
Journal of the Korean Neurological Association 2000;18(6):794-797
Some individuals may demonstrate a secondary phase nystagmus (SPN) following the caloric irrigation. It has been stated that if a SPN begins prior to 140 seconds after the onset of caloric stimulation and if the magnitude of the slow phase velocity is greater than 6 degrees/sec, then a premature reversal caloric nystagmus (PRCN) is said to exit. Thus far, there have been no reports describing PRCN in Korea. We described a typical PRCN in a patient with medulloblastoma within the 4th ventricle. The patient had a gaze-evoked horizontal and upbeating nystagmus. However, there was no indication of spontaneous nystagmus. A monothermal caloric test was administered. The initial left beating primary phase nystagmus was subsided at 60 seconds after right cold water stimulation and at 110 seconds, a right beating SPN with 14 degrees/sec of slow phase velocity was appeared and was continuous for 240 seconds. Although the precise mechanism of PRCN is unknown, vestibular nuclei damage may be related.
Caloric Tests
;
Humans
;
Korea
;
Medulloblastoma
;
Nystagmus, Physiologic*
;
Vestibular Nuclei
;
Water
10.Medulloblastoma:An Analysis of Factors Influencing on Its Prognosis.
Byung Kyu CHO ; Kyu Chang WANG ; Il Han KIM ; Sang Il LEE ; Bo Sung SIM ; Kil Soo CHOI
Journal of Korean Neurosurgical Society 1988;17(5):929-942
Authors analyzed the results of treatment in 49 cases of medulloblastoma who had been operated upon at the Seoul National University Hospital from January 1972 to June 1987. There were 2 cases(4%) of postoperative mortality(death within postoperative one month) and 13 cases of late moratlity. The 3-year overall survival rate was 49.3% and 3-year disease-free survival rate was 48.5%. The risk period of recurrence was about 2 years after surgery. The 3-year survival rate was significantly better in "grow total resection" group, "radiation dose more than 50 Gy" group, and group II(23 cases operated after July 1982) (p<0.05). The rate of posterior fossa recurrence was lower in "gross total resection" group for the patients who received posterior fossa irradiation of more than 50 Gy.
Disease-Free Survival
;
Humans
;
Medulloblastoma
;
Prognosis*
;
Recurrence
;
Seoul
;
Survival Rate