High gravidity hydatidiform mole (HM) without normal pregnancy is very rare. The challenge of managing such cases will dwell on the concern of having normal conception versus having another molar gestation and its neoplastic sequelae.

Presented in this paper is a case of a 32-year-old, gravida 5 para 0 (0040) who was admitted for the management of her fifth molar pregnancy. She underwent suction curettage and administration of methotrexate chemoprophylaxis. Genetic testing was done, which revealed a homozygous mutation in NLRP7, the gene implicated in recurrent molar gestations. This paper discusses the proper approach to determine the cause of recurrent molar pregnancies, as well as the management and prognosis of such cases.

Human ; Female ; Adult ; Gravidity ; Methotrexate ; Vacuum Curettage ; Hydatidiform Mole ; Homozygote ; Genetic Testing ; Mutation ; Prognosis ; Chemoprevention ; Molar

High gravidity hydatidiform mole (HM) without normal pregnancy is very rare. The challenge of managing such cases will dwell on the concern of having normal conception versus having another molar gestation and its neoplastic sequelae.

Presented in this paper is a case of a 32-year-old, gravida 5 para 0 (0040) who was admitted for the management of her fifth molar pregnancy. She underwent suction curettage and administration of methotrexate chemoprophylaxis. Genetic testing was done, which revealed a homozygous mutation in NLRP7, the gene implicated in recurrent molar gestations. This paper discusses the proper approach to determine the cause of recurrent molar pregnancies, as well as the management and prognosis of such cases.

Human ; Female ; Adult ; Gravidity ; Methotrexate ; Vacuum Curettage ; Hydatidiform Mole ; Homozygote ; Genetic Testing ; Mutation ; Prognosis ; Chemoprevention ; Molar

Background: The Philippines is endemic to soil-transmitted helminthiasis, a neglected tropical disease which is inadequately diagnosed and treated especially in the pregnant and lactating population. It is important that the prevalence of STH is monitored routinely to assess the effectiveness of control programs and the provision of adequate treatment, hence decreasing its associated adverse outcomes. Objective: To determine the prevalence of STH among pregnant patients consulting for antenatal care in a tertiary provincial hospital using microscopic stool analysis. Methods: This is a cross-sectional study performed on 270 patients attending antenatal care from a tertiary provincial hospital. Microscopic stool analysis using the Kato-Katz technique was the diagnostic tool used to identify presence of intestinal parasites. Data were analyzed using Stata 15. Chi Square and Mann U Whitney Tests were utilized to determine statistical significance. Variables under the adverse perinatal outcomes were subjected to odds ratio to determine correlation among those tested positive for STH. Conclusion The cumulative prevalence rate of STH is 20.7% and the most common organism identified is A. lumbricoides. Factors related to a high suspicion of STH are: older individuals; higher obstetric score; greater number of living children; increased maternal weight; anemic; underweight; lived in a family with higher number of household members; lived in a family with member treated with antihelminthics; lived in houses without water and toilet; lived in the areas of Maragondon, Mendez, Bailen, Cavite City, Noveleta and Bacoor. Moreover, preterm labor and small for gestational age fetus are the adverse perinatal outcomes identified suggestively related to STH.
Human ; Female ; Adverse Perinatal Outcomes ; Sth