1.A Clinical Observation of Meconium Aspiration Syndrome.
Chul LEE ; Kook In PARK ; Jean Young LEE ; Dong Gwan HAN
Journal of the Korean Pediatric Society 1984;27(10):958-964
No abstract available.
Infant, Newborn
;
Meconium Aspiration Syndrome*
;
Meconium*
2.Diagnosis of Meconium Aspiration by Spectrophotometric Analysis of Urine.
Mee Kyung NAMGOONG ; Baek Keun LIM ; Joong Soo KIM
Journal of the Korean Pediatric Society 1988;31(10):1275-1280
No abstract available.
Diagnosis*
;
Infant, Newborn
;
Meconium Aspiration Syndrome*
;
Meconium*
3.A Study of Meconium Aspiration Syndrome.
Chae Sup YOO ; Mee Kyung KIM ; Keun LEE
Journal of the Korean Pediatric Society 1988;31(11):1425-1431
No abstract available.
Infant, Newborn
;
Meconium Aspiration Syndrome*
;
Meconium*
4.A clinical study on meconium-stained babies.
Cheol Ki MIN ; Sung Suk BANG ; Chong Young PARK ; Hae Ran LEE ; Choon Myung RO
Journal of the Korean Pediatric Society 1991;34(1):24-30
No abstract available.
Infant, Newborn
;
Meconium Aspiration Syndrome
5.Clinical observation of meconium aspiration syndrome: prognostic implication of early meconium suctioning.
Dae Hyun KIM ; Dong Hoon KO ; Young Jong WOO ; Young Youn CHOI ; Tae Ju HWANG
Journal of the Korean Pediatric Society 1992;35(4):484-491
No abstract available.
Infant, Newborn
;
Meconium Aspiration Syndrome*
;
Meconium*
;
Mortality
;
Suction*
6.Objective Methods for Quantitative Measurement of Meconium in Amniotic Fluid.
Chang Hoon SONG ; Eun Seok YANG ; Se Hyuk JOO ; Jong Hoon PARK ; Jae Soo KIM ; Sung Hee SIN ; Yong LIM ; Sang Kee PARK
Korean Journal of Perinatology 1998;9(2):138-144
The content of meconium in amniotic fluid(AF) is important for assessing the risk of several perinatal problems such as asphyxia, meconium aspiration syndrome and various perinatal infections. This estimate is usually performed subjectively by visual inspection. The purpose of this study is to develop the objective method for quantitative measurement of meconium content in AF. Absorption spectra and meconium-crit of the solutions with various concentrations of meconium were measured. EfFects of filtration and blood contamination on the measurement of meconium content were also estimated by the same methods. Optical densities(OD) were correlated with concentrations of meconium in the whole range of scanned wavelengths. A specific peak of meconium was not available but the highest OD around 410 nm was shown. OD were linearly related to the concentrations of meconium. Meconium-crits were also well-correlated with the concentrations of meconium. Filtration of AF as well as blood contamination in AF severely affected the measurement of meconium content in AF. From the results of this study, both the spectrophotometric method and meconium-crit couid be objective methods for measuring meconium content. Both methods had merits and shortcomings. Filtration and blood contamination should be avoided for the measurement of meconium content in AF. We hope that both or either one of the two methods will be clinically used.
Absorption
;
Amniotic Fluid*
;
Asphyxia
;
Female
;
Filtration
;
Hope
;
Infant, Newborn
;
Meconium Aspiration Syndrome
;
Meconium*
7.A retrospective cohort study of tracheal intubation for meconium suction in nonvigorous neonates.
Chinese Journal of Contemporary Pediatrics 2022;24(1):65-70
OBJECTIVES:
To study the feasibility of tracheal intubation for meconium suction immediately after birth of nonvigorous neonates born through meconium-stained amniotic fluid (MSAF).
METHODS:
A retrospective cohort study was performed on nonvigorous neonates born through MSAF who were admitted to the Department of Neonatology, Zhecheng People's Hospital. The neonates without meconium suction who were admitted from July 1, 2017 to June 30, 2018 were enrolled as the control group. The neonates who underwent meconium suction from July 1, 2018 to June 30, 2019 were enrolled as the suction group. The two groups were compared in terms of the mortality rate and the incidence rates of neonatal meconium aspiration syndrome (MAS), persistent pulmonary hypertension of the newborn, pneumothorax, and pulmonary hemorrhage.
RESULTS:
There were 80 neonates in the control group and 71 in the suction group. There were no significant differences between the two groups in the incidence rates of MAS (11% vs 7%), persistent pulmonary hypertension of the newborn (5% vs 4%), pneumothorax (3% vs 1%), and death (0% vs 1%). Compared with the control group, the suction group had a significantly lower proportion of neonates requiring oxygen inhalation (16% vs 33%, P<0.05), noninvasive respiratory support (25% vs 41%, P<0.05) or mechanical ventilation (10% vs 23%, P<0.05) and significantly shorter duration of noninvasive ventilation [(58±24) hours vs (83±41) hours, P<0.05] and length of hospital stay [6(4, 8) days vs 7(5, 10) days, P<0.05].
CONCLUSIONS
Although tracheal intubation for meconium suction immediately after birth may shorten the duration of respiratory support for mild respiratory problems, it cannot reduce the incidence rate of MAS, mortality rate, or the incidence rate of serious complications in nonvigorous infants born through MSAF.
Amniotic Fluid
;
Humans
;
Infant
;
Infant, Newborn
;
Intubation, Intratracheal
;
Meconium
;
Meconium Aspiration Syndrome/therapy*
;
Retrospective Studies
;
Suction
8.A clinical epidemiological investigation of neonatal acute respiratory distress syndrome in southwest Hubei, China.
Yong-Fang ZHANG ; Xin-Qiao YU ; Jian-Hua LIAO ; Feng YANG ; Cong-Rong TAN ; Su-Ying WU ; Shi-Qing DENG ; Jun-Yuan FENG ; Jia-Yan HUANG ; Zuo-Fen YUAN ; Kai-Dian LIU ; Zhen-Ju HUANG ; Li-Fang ZHANG ; Zheng-Guo CHEN ; Hong XIA ; Lin-Lin LUO ; Yan HU ; Hua-Sheng WU ; Hong-Ling XIE ; Bao-Min FEI ; Qing-Wei PANG ; Song-Hua ZHANG ; Bi-Xia CHENG ; Lang JIANG ; Chang-Tao SHEN ; Qiong YI ; Xiao-Guang ZHOU
Chinese Journal of Contemporary Pediatrics 2020;22(9):942-947
OBJECTIVE:
To investigate the clinical features and outcome of neonatal acute respiratory distress syndrome (ARDS) in southwest Hubei, China.
METHODS:
According to the Montreux definition of neonatal ARDS, a retrospective clinical epidemiological investigation was performed on the medical data of neonates with ARDS who were admitted to Department of Neonatology/Pediatrics in 17 level 2 or level 3 hospitals in southwest Hubei from January to December, 2017.
RESULTS:
A total of 7 150 neonates were admitted to the 17 hospitals in southwest Hubei during 2017 and 66 (0.92%) were diagnosed with ARDS. Among the 66 neonates with ARDS, 23 (35%) had mild ARDS, 28 (42%) had moderate ARDS, and 15 (23%) had severe ARDS. The main primary diseases for neonatal ARDS were perinatal asphyxia in 23 neonates (35%), pneumonia in 18 neonates (27%), sepsis in 12 neonates (18%), and meconium aspiration syndrome in 10 neonates (15%). Among the 66 neonates with ARDS, 10 neonates (15%) were born to the mothers with an age of ≥35 years, 30 neonates (45%) suffered from intrauterine distress, 32 neonates (49%) had a 1-minute Apgar score of 0 to 7 points, 24 neonates (36%) had abnormal fetal heart monitoring results, and 21 neonates (32%) experienced meconium staining of amniotic fluid. Intraventricular hemorrhage was the most common comorbidity (12 neonates), followed by neonatal shock (9 neonates) and patent ductus arteriosus (8 neonates). All 66 neonates with ARDS were treated with mechanical ventilation in addition to the treatment for primary diseases. Among the 66 neonates with ARDS, 10 died, with a mortality rate of 15% (10/66), and 56 neonates were improved or cured, with a survival rate of 85% (56/66).
CONCLUSIONS
Neonatal ARDS in southwest Hubei is mostly mild or moderate. Perinatal asphyxia and infection may be the main causes of neonatal ARDS in this area. Intraventricular hemorrhage is the most common comorbidity. Neonates with ARDS tend to have a high survival rate after multimodality treatment.
China
;
Female
;
Humans
;
Infant, Newborn
;
Meconium Aspiration Syndrome
;
Pregnancy
;
Respiratory Distress Syndrome, Newborn
;
Retrospective Studies
9.Surfactant Therapy in Severe Meconium Aspiration Syndrome.
Neonatal Medicine 2013;20(3):318-322
Meconium is a strong inactivator of pulmonary surfactant. The deficiency of surfactant or surfactant dysfunction may contribute to respiratory failure in a wide group of disorders, including meconium aspiration syndrome (MAS). We reviewed the effect of pulmonary surfactant therapy for severe MAS in ours as well as other countries. In general, surfactant therapy improves pulmonary oxygenation (oxygenation index or arterial/alveolar oxygen tension) and reduces the requirement for ventilation, and oxygen supplementation or hospitalization time. However, its effects on mortality and pulmonary or extrapulmonary complications are variable. In Korean studies, outborn infants are five times more common than inborn infants; therefore, the initial hospital care at delivery including adequate tracheal suctioning is important to improve the outcome of patients with severe MAS. To confirm the effect of surfactant therapy in MAS, additional well-designed, multicenter, randomized, controlled trials are needed. In addition, determining the optimal type of surfactant therapy (bolus, lavage, or combined) and the appropriate dose and duration of therapy is important.
Hospitalization
;
Humans
;
Infant
;
Infant, Newborn
;
Meconium
;
Meconium Aspiration Syndrome
;
Oxygen
;
Pulmonary Surfactants
;
Respiratory Insufficiency
;
Suction
;
Therapeutic Irrigation
;
Ventilation
10.The Effect on Pulmonary Indices of Surfactant Therapy for Meconium Aspiration Syndrome: Systematic Review and Meta-analysis.
Hyun Jin CHOI ; Seokyung HAHN ; Soon Min LEE ; Han suk KIM ; Chong Woo BAE
Journal of the Korean Society of Neonatology 2011;18(2):189-196
PURPOSE: Surfactants have been used to improve oxygenation for infants with meconium aspiration syndrome (MAS). We evaluated the change of pulmonary indices after surfactant therapy for MAS through a systematic meta-analysis. METHODS: Relevant randomized controlled studies (RCTs) were identified by database searches in MEDLINE, EMBASE, and CENTRAL, up to June 2011, and by additional hand searches. Data were extracted regarding pulmonary indices, such as the oxygen index and arterial alveolar oxygen gradient. Meta-analyses were separately conducted for the studies of surfactant lavage therapy and surfactant bolus therapy. The risk of bias was assessed, and clinical as well as statistical heterogeneities were also investigated. RESULTS: Two RCTs for bolus surfactant therapy and two RCTs for surfactant lavage therapy were identified. The oxygenation index results were heterogeneous between the two studies in which bolus surfactant therapy was given, while a/A PO2 showed significantly better results in the treatment group over time after use of surfactant (12 hours: WMD 0.08, 95% CI 0.04-0.12; 24 hours: WMD 0.17, 95% CI 0.06-0.28). For surfactant lavage therapy, both studies consistently suggested an interventional benefit in terms of the pulmonary indices although it did not reach statistical significance. CONCLUSION: Surfactant therapy appeared to improve oxygenation of infants with MAS. Since a limited number of RCTs are available in the current literature and those studies were also clinically heterogeneous in terms of illness severity and the method of surfactant use, further research is needed to gather evidence to support surfactant therapy in MAS.
Bias (Epidemiology)
;
Hand
;
Humans
;
Infant
;
Infant, Newborn
;
Meconium
;
Meconium Aspiration Syndrome
;
Oxygen
;
Pulmonary Surfactants
;
Surface-Active Agents
;
Therapeutic Irrigation