1.Measles-Mumps-Rubella vaccine for children with egg allergy: Is admission for inpatient vaccination necessary?
Tan Mei See ; Teoh Ewe Jin ; Hor Chee Peng ; Angeline Yeoh Aing Chiee
The Medical Journal of Malaysia 2016;71(4):157-160
Introduction: Children who develop any hypersensitivity
reaction to eggs are routinely referred to hospital for
Measles-Mumps-Rubella (MMR) vaccination as inpatients to
prevent anaphylaxis. We aimed to study the association
between hypersensitivity reactions after egg exposure and
similar reactions after MMR immunisation; and examine the
necessity of hospital admission for vaccination.
Methods: A prospective observational study was conducted
in Paediatric Department in Bukit Mertajam Hospital,
Penang, between March and December 2014. Children
referred from local polyclinics for inpatient MMR vaccination
because of a history of egg allergy were recruited. The
children were observed in the ward for post vaccination
allergic reactions. Concurrently, a group of children without
egg allergy was recruited from those admitted for other
illnesses but had recent MMR vaccination at polyclinics.
Parents of these children were interviewed and asked if they
had observed any reactions post vaccination. In both
groups, sociodemographics, medical history and family
history of atopy were collected.
Results: Eighty-seven subjects were recruited in this study.
Fifty-four infants with egg allergy had previous mild allergic
reactions after exposure to eggs or egg-related products.
They were associated with a family history of egg
hypersensitivity, personal history of acute gastroenteritis
and upper respiratory tract infections. Two of them
developed cutaneous rashes post vaccination during
observation, but none developed anaphylactic or
anaphylactoid reactions. Two infants among those without
egg allergy had post vaccination fever. There was no
association between egg allergy and hypersensitivity
reactions to MMR vaccine (p=0.632).
Conclusions: MMR vaccine can be safely administered to
children with mild egg allergy, hence admission for
vaccination in the hospital is not warranted. Risk
stratification is required to ensure only infants with severe
reactions will be admitted for vaccination.
Measles-Mumps-Rubella Vaccine
3.The Effect of Measles Vaccination Before Turning 1 Year-old on the Measles Antibody Response to Immunization with MMR.
Soo Jung CHOI ; Young Jae KOH ; Young Mo SOHN ; Hoan Jong LEE ; Sung Hee OH
Journal of the Korean Pediatric Society 1998;41(7):909-916
PURPOSE: With the implementation of measles vaccination programs, the number of patients with measles has decreased. However, epidemics still occur with high morbidity in infants less than 1 year of age. This fact calls for the establishment of optimal preventive measures against measles. The study was carried out to determine the effect of measles vaccination on an infant immunized before one year of age, any the measles immunity conferred by MMR. METHODS: Seventy-seven healthy infants (13.7 +/- 1.8 months) were immunized with the MMR vaccine (Triviraten Berna : Edmonston-Zagreb strain, Rubini strain, Wistar RA 27/3 strain), 50 of the infants have received measles vaccine before turning one-year old. The antibody titers of measles-specific IgG were measured by enzyme immunoassay. RESULTS: The antibody titers before and after MMR vaccination were significantly higher in infants previously immunized with measles vaccine compared to those not immunized. However, the greater number of infants not previously immunized with measles vaccine showed significant increase of measles antibody titers after MMR vaccination compared to those previously immunized with measles vaccine. Measles vaccine failure occurred in 6 infants (12.0%), all of whom acquired measles immunity following MMR vaccination. Measles immunogenicity to MMR did not differ with respect to the age of previous measles vaccination. CONCLUSION: The results indicate that measles vaccination in infants less than 1 year of age will not decrease the measles immunity following MMR vaccination, and it is suitable to vaccinate against measles in infants between 6-12 months of age, if needed.
Antibody Formation*
;
Humans
;
Immunization*
;
Immunoenzyme Techniques
;
Immunoglobulin G
;
Infant
;
Measles Vaccine
;
Measles*
;
Measles-Mumps-Rubella Vaccine
;
Vaccination*
4.The Effect of Measles Vaccination Before Turning 1 Year-old on the Measles Antibody Response to Immunization with MMR.
Soo Jung CHOI ; Young Jae KOH ; Young Mo SOHN ; Hoan Jong LEE ; Sung Hee OH
Journal of the Korean Pediatric Society 1998;41(7):909-916
PURPOSE: With the implementation of measles vaccination programs, the number of patients with measles has decreased. However, epidemics still occur with high morbidity in infants less than 1 year of age. This fact calls for the establishment of optimal preventive measures against measles. The study was carried out to determine the effect of measles vaccination on an infant immunized before one year of age, any the measles immunity conferred by MMR. METHODS: Seventy-seven healthy infants (13.7 +/- 1.8 months) were immunized with the MMR vaccine (Triviraten Berna : Edmonston-Zagreb strain, Rubini strain, Wistar RA 27/3 strain), 50 of the infants have received measles vaccine before turning one-year old. The antibody titers of measles-specific IgG were measured by enzyme immunoassay. RESULTS: The antibody titers before and after MMR vaccination were significantly higher in infants previously immunized with measles vaccine compared to those not immunized. However, the greater number of infants not previously immunized with measles vaccine showed significant increase of measles antibody titers after MMR vaccination compared to those previously immunized with measles vaccine. Measles vaccine failure occurred in 6 infants (12.0%), all of whom acquired measles immunity following MMR vaccination. Measles immunogenicity to MMR did not differ with respect to the age of previous measles vaccination. CONCLUSION: The results indicate that measles vaccination in infants less than 1 year of age will not decrease the measles immunity following MMR vaccination, and it is suitable to vaccinate against measles in infants between 6-12 months of age, if needed.
Antibody Formation*
;
Humans
;
Immunization*
;
Immunoenzyme Techniques
;
Immunoglobulin G
;
Infant
;
Measles Vaccine
;
Measles*
;
Measles-Mumps-Rubella Vaccine
;
Vaccination*
5.A Clinical Study of Intralesional Immunotherapy Using Measles, Mumps, and Rubella Vaccine in Various Warts.
Min Sung KIM ; Sang Ho YOUN ; Chan Ho NA ; Bong Seok SHIN
Korean Journal of Dermatology 2014;52(5):326-332
BACKGROUND: Although several methods have been attempted in the treatment of warts, the traditional destructive method may be painful or ineffective and induce disfiguring scars. Therefore, a more tolerable method with fewer drawbacks is needed. OBJECTIVE: We studied the therapeutic effect of intralesional immunotherapy using the Measles, Mumps, and Rubella (MMR) vaccine and factors affecting it in patients with warts. METHODS: A retrospective study was performed in 207 patients with various types of warts, who did not meet the exclusion criteria for treatment and were followed-up from January 2011 to December 2013. Patients with warts were treated at 2-week intervals, and the therapeutic effect was evaluated 1 month after the final treatment. RESULTS: Overall, 123 (59.5%) patients experienced a greater than half reduction in the size and number of warts. In addition, younger patients (under the age of 20) (p=0.008) and those with common warts (including periungual warts) (p=0.02) showed significantly higher treatment responses. All patients complained of transient mild pain during the intralesional injections, but other side effects were rarely observed. Only 3.2% of patients who experienced a complete response had a recurrence more than 6 months after the final treatment. CONCLUSION: We suggest that intralesional immunotherapy with MMR vaccine can be considered as a primary remedy for patients who are sensitive to pain, especially children with multiple lesions, are concerned about serious side effects, or have common warts, and that treatment response will be improved by increasing the number of applications.
Child
;
Cicatrix
;
Humans
;
Immunotherapy*
;
Injections, Intralesional
;
Measles*
;
Measles-Mumps-Rubella Vaccine
;
Mumps*
;
Recurrence
;
Retrospective Studies
;
Rubella
;
Rubella Vaccine*
;
Warts*
6.Antibody Response and Adverse Reaction Following Immunization with MMR Vaccine Produced on Human Diploid Cells in Korean Children.
Sung Hee OH ; Jin Han KANG ; Young Mo SOHN ; Hoan Jong LEE ; Bok Yabg PYUN ; Chang Hwi KIM
Journal of the Korean Pediatric Society 2000;43(4):489-495
No abstract available.
Antibody Formation*
;
Child*
;
Diploidy*
;
Humans*
;
Immunization*
;
Measles
;
Measles-Mumps-Rubella Vaccine*
;
Mumps
;
Rubella
;
Vaccination
7.Remarks on measles status in Northern Viet Nam, 1996-1997
Journal of Preventive Medicine 2000;10(4):20-25
The great reduction of measles incidence is directly attributed to a good routine coverage with measles vaccine in Northern Viet Nam from 1986 to 1997. We have some remarks on measles in 1996-1997: Measles has been reported in all provinces in the North of Viet Nam. Measles has occurred in all seasons but the peak has been in spring and the lowest incidence has been in summer and fall. Measles distribution by age has been changed. Most of the reported cases were from 5 to 14 years old. 69% of cases were not immunized
Measles
;
Measles Vaccine
8.Situation of measles in the Northern region of Vietnam, 2000
Journal of Preventive Medicine 2001;11(2):11-15
Analysis of measles data of the Northern region in 2000 indicated that the disease spread widely in all provinces and all the year round. However, it mostly occurred in spring, and in this season measles outbreaks were also often recorded, 36 out of 48 measles outbreaks were confirmed by serological diagnosis. Most of the measles cases were recorded in age group 5-15 years old. Most of the measles cases in immunized children were in the age group 5-9 years. The results: the confirmed measles cases appeared in big cities, delta provinces as well as in midland and mountainous provinces. There was no significant difference regarding sex. The symptoms usually observed in the measles cases were fever, cough, coryza, rash and conjunctivitis
Measles
;
Measles Vaccine
9.Epidemiologic Study of Measles Outbreak in School-Aged Children in East KyongGi-Do Area.
In Kyu YI ; Jong Woon CHOI ; Soon Ki KIM ; Byong Kwan SON ; Jeung Gyu KIM ; Seong Ki YU ; Myung Cheol JO ; Il Suk JANG
Journal of the Korean Pediatric Society 1996;39(1):63-71
PURPOSE: There was marked decline of measles outbreak in the world since the first measles vaccine had been introduced. Recently, however, measles outbreak in the vaccinated children have been reported worldwide, which was ascribed to the possibilities of primary or secondary vaccine failure. We investigated the incidence in the school-aged children in the Kyong-gi Do area, the larger district which covers the urban and rural area, by the questionnaire. METHODS: The questionnaires which were asked to the students' parents of 14 elementary schools in and nearest Sungnam city, Kyong-Gi Do for their present age, experience of measles attack and vaccination, and the age of measles attack. The answers of this questionnaire were analysed by SAS computer program. RESULTS: 1) Measles vaccination rate at 9 months was 70.5% and MMR vaccination rate at 15 months was 91.3%. 2) Measles attack rate among unvaccinated group was 53.8%, and 16.1% in vaccinated group. There was significant low risk of measles attack among vaccinated group than unvaccinated group(relative risk=3.35, p<0.001). 3) Vaccine efficacy of measles in this age group was 69%. 4) Age distribution of measles outbreak reveals bimodal pattern, the graph shows two peak incidence of 1 year-old and 6 years-old. 5) There were no significant differences of measles incidence in the different medical care service center that measles vaccination had been done. CONCLUSIONS: Despite high rate of measles vaccine coverage in Sungnam, the attack rate of measles in the vaccinated population was relatively high. There may be due to primary, secondary vaccine failure or the other factors. The policy of measles vaccination in Korea should be reestablished as soon as possible.
Age Distribution
;
Child*
;
Epidemiologic Studies*
;
Gyeonggi-do*
;
Humans
;
Incidence
;
Korea
;
Measles Vaccine
;
Measles*
;
Measles-Mumps-Rubella Vaccine
;
Parents
;
Surveys and Questionnaires
;
Vaccination
10.Epidemiological characteristics of mumps in mainland China from 2004 to 2018 and key population for prevention and control.
Rui-Ju JIANG ; Qiong-Zhou YIN ; Ming-Jue XU ; Zhi-Mei ZHAO ; Yan DENG ; Yan-Chun CHE
Chinese Journal of Contemporary Pediatrics 2019;21(5):441-444
OBJECTIVE:
To investigate the epidemiological characteristics of mumps in mainland China from 2004 to 2018, and to provide data for the key population for prevention and control of mumps.
METHODS:
The epidemiological characteristics of mumps were analyzed with reference to the data of the cases of mumps reported in the National Scientific Data Sharing Platform for Population and Health and Disease Prevention and Control Bureau of National Health Commission of the People's Republic of China. Descriptive epidemiology was used to analyze the epidemiological characteristics of mumps.
RESULTS:
A total of 4 272 368 cases of mumps were reported in China during 2004-2018, with an average annual reported incidence rate of 21.44/100 000. A single dose of mumps-containing vaccine was added to the national Expanded Program of Immunization in 2008, but the annual incidence rate ranged from 12.84/100 000 to 35.59/100 000. The second dose of measles, mumps and rubella combined attenuated live vaccine was included in the routine immunization in Beijing, Tianjin and Shanghai, and then the average incidence rate of mumps reported in these three regions dropped to about 10/100 000. From 2004 to 2016, the population aged 3-14 years accounted for 81.16% of all patients with mumps. The children aged 6 years had the highest incidence rate of mumps during 2004-2013.
CONCLUSIONS
A single dose of mumps-containing vaccine has no obvious effect on the incidence rate of mumps. Children aged 6 years have the highest incidence rate of mumps. A booster dose of mumps-containing vaccine should be given to preschool children.
Adolescent
;
Child
;
Child, Preschool
;
China
;
Humans
;
Measles
;
Mumps
;
Mumps Vaccine
;
Rubella