1. Comparative investigation of the free radical scavenging potential and anticancer property of Diospyros blancoi (Ebenaceae)
Muhammad Ali KHAN ; Md. Mahbubur RAHMAN ; Md. Nazmul SARDAR ; Md. Saiful Islam ARMAN ; Mamunur RASHID ; Golam SADIK ; A.H.M. Khurshid ALAM ; Md. Badrul ISLAM ; Md. Jahangir Alam KHANDAKAR ; A.H.M. Khurshid ALAM
Asian Pacific Journal of Tropical Biomedicine 2016;6(5):410-417
Objective: To investigate the comparative effects of Diospyros blancoi (Ebenaceae) leaves (DBL), root bark (DBRB) and stem bark (DBSB) on free radicals and cancer. Methods: The polyphenol contents, antioxidant and free radical scavenging properties were determined using standard spectrophotometric methods. Cytotoxicity and anticancer activities were performed on brine shrimp nauplii and Ehrlich ascite carcinoma cells, respectively. Results: Among the extracts, DBSB showed the highest total antioxidant capacity and reducing capacity on ferrous ion. Based on 1,1-diphenyl-2-picrylhydrazyl and hydroxyl radical scavenging activities, DBSB showed (95.760 ± 0.343)% and (67.460 ± 2.641)% scavenging with IC
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