1.Formulation of a Protein and Fibre Enriched Soy-Mushroom Health Drink Powder Compared to Locally Available Health Drink Powders
Tasnim Farzana ; Suman Mohajan ; Md. Nur Hossain ; Monzur Morshed Ahmed
Malaysian Journal of Nutrition 2017;23(1):129-138
Protein malnutrition is a major concern in Bangladesh where there is a high
dependence on cereal-based diets. Use of protein-calorie sources of plants like soybean and
mushroom as a dietary supplement may provide a solution. This study was designed to
formulate a high protein and fibre enriched soy-mushroom health drink powder, and to
compare its nutritional contents with locally available health drink powders. Methods:
Soy-mushroom health drink powder was developed mainly from soy flour, mushroom,
germinated wheat flour, malt extract and milk powder. Three locally available health drink
powders were randomly selected. Proximate and microbiological analyses and sensory
evaluation were undertaken by standard methods. Data were analysed using Statistical
Package for the Social Sciences (SPSS). Results: The moisture, ash, protein, fat, fibre,
carbohydrate and energy contents of the developed soy-mushroom health drink powder
ranged from 3.04-3.96%, 3.23-7.4%, 8.98-21.37%, 1.10-10.13%, 0.04%-1.50%, 59.93-81.58%
and 363.54-416.40 kcal/100g, respectively. The soy-mushroom product had the highest
content of protein, fibre, energy and the lowest content of carbohydrate compared to the
other health drink powders. Based on sensory analysis, the soy-mushroom product showed
high acceptability. Microbiological assessment showed the shelf life of this product to be
one year. Conclusion: The soy-mushroom health drink powder was nutritionally superior
to locally available health drink powders and could serve as a nutritional supplement.
2.Ovarian volume is more closely related to the different manifestations of polycystic ovary syndrome than follicle number per ovary
Shazia AFRINE ; Jasmine Ara HAQUE ; Md Shahed MORSHED ; Hurjahan BANU ; Ahmed HOSSAIN ; Muhammad Abul HASANAT
Clinical and Experimental Reproductive Medicine 2023;50(3):200-205
Objective:
Polycystic ovary (PCO), a diagnostic component of polycystic ovary syndrome (PCOS), requires either an ovarian volume (OV) criterion or a follicle number per ovary (FNPO) criterion. This study investigated the association of OV and FNPO criteria with various manifestations of PCOS.
Methods:
This cross-sectional study was conducted at a university hospital among 100 patients newly diagnosed with PCOS (according to the revised Rotterdam criteria). Fasting blood samples were collected to measure glucose, total testosterone (TT), luteinizing hormone (LH), follicle-stimulating hormone (FSH), lipid, insulin, and hemoglobin A1c levels. An oral glucose tolerance test was performed. Transabdominal or transvaginal ultrasound of the ovaries was done, depending on patients’ marital status. All investigations were conducted in the follicular phase of the menstrual cycle. OV >10 mL and/or FNPO ≥12 indicated PCO. A homeostasis model assessment of insulin resistance (IR) value ≥2.6 indicated IR, and metabolic syndrome (MS) was defined according to the international harmonization criteria.
Results:
Seventy-six participants fulfilled the OV criterion, 70 fulfilled the FNPO criterion, and 89 overall had PCO. Both maximum OV and mean OV had a significant correlation with TT levels (
3.The Impact of COVID-19 on Healthcare Services in Bangladesh: A Qualitative Study on Healthcare Providers’ Perspectives
Sharmin PARVEEN ; Md. Shahriar MAHBUB ; Nasreen NAHAR ; K. A. M. MORSHED ; Nourin RAHMAN ; Ezzat Tanzila EVANA ; Nazia ISLAM ; Abu Said Md. Juel MIAH
Journal of Preventive Medicine and Public Health 2024;57(4):356-369
Objectives:
The objective of this study was to explore healthcare providers’ experiences in managing the coronavirus disease 2019 (COVID-19) pandemic and its impact on healthcare services.
Methods:
A qualitative study was conducted with 34 healthcare professionals across 15 districts in Bangladesh. Among the participants, 24 were health managers or administrators stationed at the district or upazila (sub-district) level, and 10 were clinicians providing care to patients with COVID-19. The telephone interviews were conducted in Bangla, audio-recorded, transcribed, and then translated into English. Data were analyzed thematically.
Results:
Most interviewees identified a range of issues within the health system. These included unpreparedness, challenges in segregating COVID-19 patients, maintaining isolation and home quarantine, a scarcity of intensive care unit beds, and ensuring continuity of service for non-COVID-19 patients. The limited availability of personal protective equipment, a shortage of human resources, and logistical challenges, such as obtaining COVID-19 tests, were frequently cited as barriers to managing the pandemic. Additionally, changes in the behavior of health service seekers, particularly increased aggression, were reported. The primary motivating factor for healthcare providers was the willingness to continue providing health services, rather than financial incentives.
Conclusions
The COVID-19 pandemic presented a unique set of challenges for health systems, while also providing valuable lessons in managing a public health crisis. To effectively address future health crises, it is crucial to resolve a myriad of issues within the health system, including the inequitable distribution of human resources and logistical challenges.
4. Clinical, biochemical and imaging characteristics of adrenal histoplasmosis in immunocompetent patients in a non-endemic area: A case series
Sharmin JAHAN ; Md FARIDUDDIN ; Md CHOMON-ABDULLAH ; Emran-Ur-Rashid CHOWDHURY ; Emran-Ur-Rashid HASANAT ; Tahseen MAHMOOD ; Ibrahim FAISAL ; Md MORSHED ; Anil YADAV ; Anil SHAH
Asian Pacific Journal of Tropical Medicine 2021;14(10):471-476
Objective: To document the clinical, biochemical and imaging phenotypes of immunocompetent patients with adrenal histoplasmosis. Methods: The clinical, biochemical and radiologic data of 18 immunocompetent patients [age: 45.00 (39.25, 56.25) years, median (IQR), m/f (16/2)] with adrenal histoplasmosis presenting in the Department of Endocrinology, BSMMU between 2014 and 2020 were retrospectively analyzed. Results: All patients were seronegative for HIV infection, and 27.8% (5/18) had well controlled diabetes mellitus. The median duration of the symptoms was 6.00 (IQR: 4.00, 11.25) months. All had significant weight loss, anorexia and weakness. Fever was present in 61.1% (11/18) patients and night sweat was present in 27.8% (5/18) cases. Hypotension and hyperpigmentation were present in 55.6% (10/18) and 66.7% (12/18) cases, respectively. Three of 18 patients presented with adrenal crisis. Hyponatremia occurred in 55.6% (10/18) cases, but none had hyperkalemia. Thirteen of 18 patients had adrenal insufficiency whereas 83.3% (15/18) had high adrenocorticotropic hormone. CT scan revealed bilateral adrenal enlargement in all cases with oval shape and regular margin. All were hypodense having radiodensity 21-90 hounsfield unit, and 11.1% (2/18) were heterogeneous in contrast enhancement. None had noticeable calcification whereas 1.1% (2/18) cases had central necrosis with peripheral rim enhancement. Hepatomegaly was present in 6 cases, splenomegaly in 3 cases and 5 patients had abdominal lymphadenopathy. Histoplasmosis were confirmed by positive fine needle aspiration cytology of adrenal tissue. Conclusions: Adrenal histoplasmosis should be considered in the list of differentials of bilateral adrenomegaly in immunocompetent individuals even living in non-endemic areas.
5.Hypothalamic-Pituitary-Adrenal axis activity in SARS-CoV-2 infected noncritically ill hospitalized patients
Hurjahan Banu ; Nusrat Sultana ; Md Shahed Morshed ; MA Hasanat ; Ahmed Abu Saleh ; Shohael Mahmud Arafat
Journal of the ASEAN Federation of Endocrine Societies 2023;38(2):65-70
Objectives:
This study determined the baseline hormonal levels of the hypothalamic-pituitary-adrenal axis and their associated factors in noncritically ill hospitalized patients with coronavirus disease 2019 (COVID-19).
Methodology:
This cross-sectional observational study was carried out in 91 noncritical RT-PCR-confirmed COVID-19 patients (18-65 years) recruited consecutively from the COVID unit, of two tertiary care hospitals over a period of six months. After screening for exclusion criteria relevant history and physical examinations were done, and blood was drawn between 07:00 am to 09:00 am in a fasting state to measure serum cortisol and plasma adrenocorticotropic hormone (ACTH) by chemiluminescent microparticle immunoassay.
Result:
Of 91 patients, 54, 26, and 11 had mild, moderate, and severe disease respectively. Median values of serum cortisol (p=0.057) and plasma ACTH (p=0.910) were statistically similar among the severity groups. Considering cortisol cut-off of 276 nmol/L (<10 μg/dL), the highest percent of adrenal insufficiency was present in severe (27.3%), followed by mild (25.9%) and least in moderate (3.8%) COVID-19 cases. Using the cortisol/ACTH ratio >15, only 6.6% had enough reserve.
Conclusions
The adrenocortical response was compromised in a significant percentage of noncritically ill hospitalized patients with COVID-19, which is unrelated to infection severity, with greater percentages present in severely infected cases.
Hydrocortisone
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Adrenocorticotropic Hormone
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SARS-CoV-2
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COVID-19