1.Clinical characteristics and risk factors of primary gouty arthritis in Xinjiang area
Pengkai FAN ; Yuping SUN ; Mire-Kuerban ZA ; Mayna KAHAER ; Ruirui SONG ; Feili XU
International Journal of Laboratory Medicine 2019;40(3):260-265
Objective To explore the clinical features and risk factors of primary gout in Xinjiang area.Methods A total of 364 patients with gout and 546 healthy crowd were divided into two groups.A unified questionnaire was used to investigate and detect relevant biochemical indicators.Related biochemical indexes were examined and analyzed.Logistic regression model was established to analyze the risk factors related to gout.Results The mean age of onset of gout was 42.95±11.93.More than two joints were involved in56.32% of patients with gout.BMI, SUA, GLU, BUN, CREA, TG, TC, LDL-C of gout group were significantly higher than those of control group (P<0.01), while HDL-C was significantly lower than that of control group (P<0.01).The advanced age, high uric acid hematic disease, high blood pressure, high blood sugar, smoking, drinking, family history of gout, BMI, high TG levels, and high creatinine hematic disease, high blood LDL-C may be risk factors for gout occurence (OR=3.767, 103.482, 3.621, 2.934, 3.140, 3.482, 4.198, 1.102, 1.498, 1.102, 1.498), while aerobic exercise regularly (three times or more a week) is the protection factor gout occurs.Conclusion The average age of patients with gout in Xinjiang is lower than the national level.The distribution of the degree of culture of patients with gout in Xinjiang may have no obvious rule, and the population with medium and low degree of culture is the main affected population.More than half of patients with gout are now involved in more than two joints.The most common associated with gout is hypertension.Beer/liquor and high-fat diet are the most common dietary factors for patients with gout in Xinjiang.The advanced age, hyperuricemia, hypertension, hyperglycemia, smoking, drinking, hypercreatinine, BMI, high-TG, high LDL-C and family history of gout may all increase the risk of gout, while aerobic regular exercise (more than 3 times per week) may reduce the risk of gout.
2. Association between atherogenic index of plasma and renal function impairment in patients with gout
Ruirui SONG ; Kahaer MAYNA ; Bei ZHANG ; Xiaobo ZHANG ; Ying LU ; Ge TIAN ; Shanshan YANG ; Yuping SUN
Chinese Journal of Endocrinology and Metabolism 2019;35(12):1043-1049
Objective:
To study the relationship between atherogenic index of plasma (AIP)and renal impairment in male patients with gout.
Methods:
A retrospective analysis of 821 male subjects was conducted to measure the relevant biochemical indicators and to calculate the AIP, endogenous creatinine-clearance rate (Ccr), and estimated glomerular filtration rate (eGFR). EpiData 3.1 software was used for data entry, SPSS21.0 was used for statistical analysis, and GraphPad Prism 6.0 software was used for charts.
Results:
Compared with control group, AIP, serum uric acid, triglyceride in gout group were significantly higher (all