1.Efficiency of Matricaria chamomilla CH(12) and number of doses of rabies vaccine on the humoral immune response in cattle.
Luis Souza DE SOUZA REIS ; Neuza Maria FRAZATTI-GALLINA ; Rosana DE LIMA PAOLI ; Rogerio GIUFFRIDA ; Avelino ALBAS ; Eunice OBA ; Paulo Eduardo PARDO
Journal of Veterinary Science 2008;9(4):433-435
This study evaluated the effect of Matricaria chamomilla and vaccination frequency on cattle immunization against rabies. Four groups (n = 15 /group) were treated with or without Matricaria chamomilla CH(12) and vaccinated with one or two doses of rabies vaccine (30 day interval). No effect of chamomile was found on cattle immunization against rabies; however, antibody titers were protective in cattle vaccinated twice, while 93.3% of cattle vaccinated only once had titers under 0.5 UI/ml after 60 days. In conclusion, the use of chamomile did not alter the humoral immune response in cattle, and two vaccine doses are suggested for achieving protective antibody titers.
Animals
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Antibodies, Viral/blood
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Cattle
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Dose-Response Relationship, Immunologic
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Drug Administration Schedule
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Drug Interactions
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Matricaria/*chemistry
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Plant Extracts/chemistry/*pharmacology
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Rabies Vaccines/administration & dosage/*immunology
2.Effect of German chamomile oil application on alleviating atopic dermatitis-like immune alterations in mice.
Soon Hee LEE ; Yong HEO ; Young Chul KIM
Journal of Veterinary Science 2010;11(1):35-41
Historically, German chamomile (GC) oil has been used for treatment of skin disorders. BALB/c mice were sensitized twice a week with 100 microL of 1% 2,4-dinitrochlorobenzene (DNCB) and challenged twice the following week with 100 microliter of 0.2% DNCB for atopic dermatitis induction. Thereafter, 3% GC oil was applied daily (70 microliter, 6 times week) on the dorsal skin for 4 weeks. Saline or jojoba oil was used for the control mice. Blood was collected after second DNCB challenge, and at 2 and 4 weeks after initiating oil application. Serum IgE levels were significantly lowered in the GC oil application group at the end of the 4-week application period. The GC oil application for 4 weeks resulted in reduction in serum IgG1 level compared with that after 2-week application. The GC oil application group showed a significantly lower serum histamine level than the control group 2 weeks after oil application. Scratching frequency of the GC oil application group was significantly lower than either control groups. This study is to demonstrate GC oil's immunoregulatory potential for alleviating atopic dermatitis through influencing of Th2 cell activation.
Animals
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Behavior, Animal/drug effects
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Chamomile/*immunology
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Dermatitis, Atopic/drug therapy/*immunology
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Disease Models, Animal
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Histamine/blood
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Immunoglobulin E/blood
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Immunoglobulin G/blood
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Interleukin-4/analysis
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Male
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Matricaria/*immunology
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Mice
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Mice, Inbred BALB C
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Phytotherapy/*methods
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Specific Pathogen-Free Organisms
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Th2 Cells/*immunology