1.A Phase Contrast Microscopic Study on the Induction of Cellular Deformation in Mast Cells.
Kum Duck CHOI ; Yung Keun OH ; Dal Uck PARK ; Kyu Soon RHIM ; Tong Hun CHO
Yonsei Medical Journal 1966;7(1):1-6
The influence of colchicine, colcemid, ginseng-alcohol extract, saponin, garlic alcohol-ether extract, and X-irradiation on free floating peritoneal mast cells were studied in rats by means of a phase contrast microscope. After the intraperitoneal injection of colchicine or colcemid the mast cells of the albino rat peritoneal fluid show an altered morphology. Ginseng-alcohol extract, allicin extracted from garlic, and X-irradiation do not elicit this cytological response.Mast cells exposed to saponin exhibit a severe destruction and degranulation. The relation of the mast cell-damaging agents, metabolic poisons, and X1-irradiation to the mast cell response is discussed with reference to the morphological changes. These are compared with the data of Padawer (1960, 1966).
Animals
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Colchicine/*pharmacology
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Mast Cells/*drug effects/*radiation effects
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Microscopy, Phase-Contrast
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*Panax
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Plant Extracts/pharmacology
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*Plants, Medicinal
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*Radiation Injuries, Experimental
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Rats
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Saponins/*pharmacology