Collagen is widely used for regenerative therapy and pharmaceutical applications as one of the most useful scaffolds. Collagen is the most abundant protein in vertebrates and the natural substrate of various types of animal cells. Bone and dentin are mineralized tissues and almost similar in chemical components. They consist of collagen (18%), non-collagenous proteins (2%), hydroxyapatite (70%) and body fluid (10%) in weight volume. Pepsin-digested, type I collagen (atelocollagen) and heat-denatured collagen (gelatin) are basic collagenous materials for medical use. Demineralized dentin matrix (DDM) and demineralized bone matrix (DBM) belong to acid-insoluble group, and vital tooth-derived DDM is a unique dentin material including cementum and growth factors. In this review, collagen-based materials will be introduced and discussed for bone regenerative surgery.
Animals ; Biology ; Body Fluids ; Bone Matrix ; Collagen ; Collagen Type I ; Dental Cementum ; Dentin ; Durapatite ; Intercellular Signaling Peptides and Proteins ; Proteins ; Regeneration ; Vertebrates

In cases of severe alveolar bone atrophy in the posterior maxillary area, which has only a thin sinus floor, the autogenous tooth bone graft block (ABTB) was used to wrap the implant to enhance its primary stability and osseointegration in the sinus. These cases with four years of clinical follow-up demonstrate the applicability of the ABTB in maxillary sinus membrane elevation to improve the outcomes of implant placement.
Alveolar Bone Loss ; Follow-Up Studies ; Maxillary Sinus ; Membranes ; Osseointegration ; Tooth* ; Transplants*

Animals ; Biopsy ; Blotting, Western ; Bone Substitutes ; Crowns ; Dentin ; Humans ; Mice ; Mice, Nude ; Osteogenesis ; Sodium ; Tissue Donors ; Tooth ; Transplants

With successful extraction of growth factors and bone morphogenic proteins (BMPs) from mammalian teeth, many researchers have supported development of a bone substitute using tooth-derived substances. Some studies have also expanded the potential use of teeth as a carrier for growth factors and stem cells. A broad overview of the published findings with regard to tooth-derived regenerative tissue engineering technique is outlined. Considering more than 100 published papers, our team has developed the protocols and techniques for processing of bone graft material using extracted teeth. Based on current studies and studies that will be needed in the future, we can anticipate development of scaffolds, homogenous and xenogenous tooth bone grafts, and dental restorative materials using extracted teeth.
Bone Substitutes ; Dentin ; Intercellular Signaling Peptides and Proteins ; Proteins ; Stem Cells ; Tissue Engineering ; Tooth ; Transplants