1.Recent Advances in Endoscopic Submucosal Dissection for Gastric Cancer: Focusing on Expanded Indications and Technological Innovations
Waku HATTA ; Yohei OGATA ; Koya OGASAWARA ; Yutaka HATAYAMA ; Masahiro SAITO ; Takeshi KANNO ; Tomoyuki KOIKE ; Atsushi MASAMUNE
Journal of Gastric Cancer 2026;26(1):76-91
The indications for endoscopic resection (ER) and the criteria for the curability of early gastric cancer (EGC) have been expanding. Among Korea, Japan, and Europe, Korea has the most strictly defined indication for ER, followed by Europe and Japan, whereas the curability criteria are relatively similar. Additional surgery is the standard treatment after noncurative resection; however, it is not frequently performed in older patients in clinical practice. Several risk-scoring systems have been developed to further stratify the risk of lymph node metastasis after noncurative resection, and they may help refine the indications for ER and curability assessment in older patients. Nevertheless, the current evidence remains insufficient to establish recommendations specific to this population. In older patients, most deaths are attributable to non-gastric cancer-related causes, regardless of the post-resection treatment strategy. Therefore, in addition to gastric cancer-specific mortality, non-gastric cancer-related mortality and quality of life should be considered.Endoscopic submucosal dissection (ESD) techniques continue to evolve. Traction methods and multibending endoscopes are useful for achieving safe and reliable ESD in selected cases.Although no intervention has been proven effective in reducing delayed bleeding after gastric ESD in randomized controlled trials, several closure methods have shown promising results in retrospective or phase II studies. Furthermore, novel image-enhanced endoscopies may help improve the technical success of gastric ESD. This review provides an evidence-based perspective that may guide optimal management of patients with EGC.
2.Impact of car seat recline angle on global spinal alignment and seat belt positioning: a prospective observational study in Japan
Norihiro NISHIDA ; Tomohiro IZUMIYAMA ; Ryusuke ASAHI ; Hidenori SUZUKI ; Masahiro KOIKE ; Masahiro FUNABA ; Kazuhiro FUJIMOTO ; Yusuke ICHIHARA ; Yogesh KUMARAN ; Hiroshi HAMANO ; Shigeru SUGIMOTO ; Takashi SAKAI
Asian Spine Journal 2026;20(2):283-293
Methods:
Lateral radiographs were obtained from 100 healthy adults in standing and seated postures at 25°, 35°, and 45° recline angles. Spinal parameters (cervical lordosis, thoracic kyphosis, thoracolumbar kyphosis, lumbar lordosis, sacral slope, pelvic tilt, and T1 spinopelvic inclination) and seat belt metrics (X-value, Z-value, and lap belt angle) were measured. Multivariate regression was used to assess associations with sex, age, height, and body mass index (BMI).
Results:
Reclining reduced cervical/lumbar lordosis and sacral slope, while thoracic kyphosis and pelvic tilt increased. Higher BMI was associated with a cranially shifted and more horizontal lap belt. Taller individuals showed greater T1 spinopelvic inclination and pelvic parameters. Females exhibited more pronounced thoracic kyphosis and pelvic retroversion across reclining angles.
Conclusions
Car seat recline significantly alters spinal alignment and seat belt positioning, with changes influenced by age, height, and BMI. These findings support ergonomic improvements in seat design and may inform surgical planning for ASD.
3.Correlation between postoperative shoulder imbalance and distal adding-on and distal junctional kyphosis in Lenke type 2 adolescent idiopathic scoliosis: a retospective study
Norihiro ISOGAI ; Satoshi SUZUKI ; Nao OTOMO ; Yohei TAKAHASHI ; Masahiro OZAKI ; Toshiki OKUBO ; Osahiko TSUJI ; Narihito NAGOSHI ; Mitsuru YAGI ; Masaya NAKAMURA ; Morio MATSUMOTO ; Kota WATANABE
Asian Spine Journal 2026;20(2):272-282
Methods:
This study included 62 patients with Lenke type 2 AIS who underwent posterior correction and fusion surgeries. The patients were categorized into the PSI and non-PSI groups based on their radiographic shoulder height 2 years after surgery. Radiographic parameters, lower end vertebra (LEV), lower instrumented vertebra (LIV), sagittal stable vertebra (SSV), postoperative DA and DJK, and Scoliosis Research Society 22 scores were compared between the two groups using unpaired t -tests or Pearson’s chi-square tests.
Results:
Twenty-eight patients in the PSI group and 34 in the non-PSI group were evaluated. Three patients had DA in the PSI group and 10 with DA and four with DJK in the non-PSI group. LIV–LEV was higher in the PSI group than in the non-PSI group. Although the LIV–SSV was not significantly different between the two groups, among the three patients with DJK, two had LIV–SSV of −3, one had −1, and one had 0. No significant differences in other examinations were noted between the two groups.
Conclusions
Although more proximal LIV selection might lead to stable DA and DJK, the LIV selection should not be extended distally to prevent DA and DJK because favorable shoulder balance and clinical outcome can still be achieved.
4.Comparison between Hounsfield unit value and vertebral bone quality score for adjacent vertebral fracture risk assessment after balloon kyphoplasty: a propensity score matching study
Koji MATSUMOTO ; Masahiro HOSHINO ; Hirokatsu SAWADA ; Sosuke SAITO ; Tomohiro FURUYA ; Hirohiko TSUJISAWA ; Ryo OZAKI ; Kazuyoshi NAKANISHI
Asian Spine Journal 2026;20(1):52-59
Methods:
This single-center study included 130 patients with osteoporotic vertebral fractures who underwent BKP and preoperative computed tomography and magnetic resonance imaging. After propensity score matching for age; sex; body mass index; fracture level; use of steroids, teriparatide, or osteoporosis medication; and previous AVF, patients were classified into the AVF (−) and AVF (+) groups, each of which included 34 patients. Bone strength was assessed using the L1 HU, L1–4 HU (mean HU of L1–L4), L1 VBQ, and L1–4 VBQ. Group differences were analyzed, and the predictive accuracy for AVF was evaluated using area under the receiver operating characteristic curve (AUC).
Results:
L1 HU was significantly lower in the AVF (+) group than in the AVF (−) group (92.1±29.4 vs. 71.6±21.4, p =0.013). No significant differences between the groups were observed for L1–4 HU, L1 VBQ, and L1–4 VBQ. L1 HU had the highest AUC (0.657), compared with those for L1–4 HU (0.625), L1 VBQ (0.524), and L1–4 VBQ (0.523). The predictive accuracy of L1 was superior to that of L1–4 for both HU and VBQ scores.
Conclusions
HU was superior to VBQ in predicting AVF risk after BKP, with L1 HU being the most effective indicator of bone strength and AVF risk.
5.RNF213 p.R4810K Variant and Intracranial Atherosclerosis: Increased Risk in Obese Variant Carriers
Masamitsu TAKASHIMA ; Takuya KIYOHARA ; Kuniyuki NAKAMURA ; Yuichi OZAKI ; Fumitaka YOSHINO ; Go HASHIMOTO ; Masaoki HIDAKA ; Noriyuki SAHARA ; Fumi IRIE ; Yoshinobu WAKISAKA ; Ryu MATSUO ; Masahiro KAMOUCHI ; Takanari KITAZONO ; Tetsuro AGO ;
Journal of Stroke 2026;28(1):172-175
7.Facilitating Memory Consolidation through Light Exercise: The Role of the Locus Coeruleus-Hippocampal Dopaminergic Pathway
Taichi HIRAGA ; Toshiaki HATA ; Shingo SOYA ; Joshua P JOHANSEN ; Tomonori TAKEUCHI ; Masahiro OKAMOTO ; Hideaki SOYA
Japanese Journal of Physical Fitness and Sports Medicine 2025;74(1):110-110
8.A Case of a Peritoneal Dialysis Patient Who Underwent OPCAB for Acute Coronary Syndromes after Debranching TEVAR
Kazuki TAMURA ; Yasuyuki YAMADA ; Masahiko EZURE ; Yutaka HASEGAWA ; Joji HOSHINO ; Shuichi OKADA ; Yoshifumi ITODA ; Hiroyuki MORISHITA ; Masahiro SEKI ; Takashi SODA
Japanese Journal of Cardiovascular Surgery 2025;54(2):49-52
An 82-year-old male patient who had a history of ischemic heart disease (IHD) and Debranching Thoracic Endovascular Aortic Repair (TEVAR) (right axillary artery-left axillary artery-left common carotid artery) was admitted to our hospital due to sudden chest pain. The diagnosis revealed acute coronary syndrome: 2-vessel lesions, including the left main trunk (LMT) (right coronary artery (RCA) #2 75%, #3 90%, LMT #5 50%, and left anterior descending (LAD) branch #7 75%). Plain Old Balloon Angioplasty (POBA) was performed on the responsible lesion, RCA (#2-3). Off-pump Coronary Artery Bypass Grafting (OPCAB) was initially planned for the remaining lesion. However, cardiogenic shock occurred, and an emergency OPCAB (SVG-LAD, SVG-#4PD) was performed via partial sternotomy (inverted L-shaped incision on the left side), using intra-aortic balloon pumping (IABP). The patient underwent revascularization using great saphenous vein grafts due to the potential for postoperative pleuroperitoneal communication in patients undergoing peritoneal dialysis, as well as the risk of impaired internal thoracic artery (ITA) flow caused by debranching in future involving internal shunts for dialysis. It is important to consider not only the graft but also the thoracotomy, taking into account the perspectives of early weaning and the prevention of perioperative complications.
9.A Case of Hybrid Surgery for Left Subclavian Artery Aneurysm Concomitant with Loeys-Dietz Syndrome in Childfood
Masahiro RYUGO ; Osamu MONTA ; Noriyuki KASHIYAMA ; Shusaku MAEDA ; Hiroki NAKATSUJI ; Yasushi TSUTSUMI
Japanese Journal of Cardiovascular Surgery 2025;54(2):91-94
We report on a rare case of a left subclavian artery aneurysm concomitant with Loeys-Dietz Syndrome (LDS) which required us to operate in childhood. A 12-year-old female, who had been diagnosed with LDS by genetic examination one year eariler, was revealed to be suffering from a left subclavian artery aneurysm (25 mm in diameter) by follow up chest MRI scan. Hybrid surgery consisting of coil embolization of aneurysm and surgical revascularization of the left subclavian artery and left vertebral artery was performed successfully. The patient was discharged on postoperative day 8.
10.A Study of the Different Effects of Combined High-frequency Repetitive Transcranial Magnetic Stimulation Therapy and Intensive Speech Language Hearing Therapy between Stimulation Sides and Regions Identified by Subscales of the Standard Language Test of Aphasia in Post-stroke Aphasia
Kensuke OHARA ; Takuya HADA ; Minori YAMADA ; Yuina KOUTOU ; Yasuhide NAKAYAMA ; Masahiro ABO
The Japanese Journal of Rehabilitation Medicine 2025;():23048-
Objective: In recent years, repetitive transcranial magnetic stimulation (rTMS) has shown promise in treating aphasia. While previous reports used the Standard Language Test of Aphasia (SLTA) for evaluation of language functions, the difficulty level of each task in SLTA varies. To show the effects of rTMS in more detail, it is necessary to use weighted values for the SLTA scores. This study aimed to assess the impact of high-frequency rTMS on aphasia using the deviation values of the SLTA.Methods: Thirty-one post-stroke aphasic patients participated in this study [mean (SD) age 58.0 (10.1) years, 15 infarction and 16 hemorrhage] from 2017 to 2021. The average (SD) duration from the onset of stroke to the intervention was 41.1 (31.1) months. Prior to admission, brain sites for rTMS were determined by detecting activation during the word-repeat task using functional MRI. A two-week inpatient treatment, including daily high-frequency rTMS and speech language hearing therapy (excluding Sundays), was conducted. In statistical analysis, SLTA scores were converted into deviation values, with participants grouped by rTMS sites (frontal lobe, temporal lobe, left/right hemisphere) for pre- and post-treatment comparisons.Results: rTMS sites included right frontal lobe (6 cases), left frontal lobe (10 cases), right temporal lobe (5 cases), and left temporal lobe (10 cases). Pre- and post-treatment comparisons showed significant improvements in overall mean scores and speech items in all groups. Additionally, significant enhancements in auditory comprehension items were observed in the right hemisphere and frontal lobe stimulation groups.Conclusion: High-frequency rTMS shows promise that it can improve language function regardless of the stimulation site, and auditory comprehension may be improved specifically by the right hemisphere and left frontal lobe stimulation. This suggests its potential as a valuable therapeutic intervention.


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