None.

In late August 2014, three autochthonous dengue cases were reported in Japan. Since then, as of 17 September 2014, a total of 131 autochthonous cases have been confirmed. While cases were reported from throughout Japan, the majority were linked to visiting a large park or its vicinity in Tokyo, and the serotype detected has been serotype 1. We report preliminary findings, along with the public health response activities, of the first documented autochthonous dengue outbreak in Japan in nearly 70 years.Dengue is an acute, mosquito-borne febrile illness caused by a flavivirus found widely in the Asia-Pacific region, particularly in South-East Asia. While the most competent mosquito species for dengue virus transmission is believed to be Aedes aegypti, Aedes albopictus is also a competent vector present in much of Japan during the warmer months. Infection with dengue virus may cause fever, headache, muscle pain and/or rash but may also be mild or asymptomatic. While there is no specific treatment, with early and appropriate medical care, the likelihood of infections resulting in severe forms or death is rare. In Japan, dengue has been a notifiable disease since April 1999. Physicians are required to report demographic, clinical and exposure history information of laboratory-confirmed cases to the local public health centre that are then reported to the Ministry of Health, Labour and Welfare (MHLW) and the National Institute of Infectious Diseases (NIID).

Introduction: In Japan, syphilis notifications have increased. Men who have sex with men (MSM) in Tokyo have contributed substantially to the increase in syphilis notifications. We thus aimed to determine the correlates of incident syphilis among them. Methods: MSM who attended a Tokyo clinic that serves sexual minorities were recruited in a case-control study in 2015. A case was seropositive for primary/secondary/asymptomatic syphilis at enrolment visit and seronegative at prior visit or had oral ulcers positive for Treponema pallidum DNA at enrolment. For each case, two controls seronegative at enrolment and prior visit were selected. Using logistic regression, odds ratios (ORs) and 95% confidence intervals (CIs) were estimated to assess for correlates of case status. Results: Among 35 cases, the median age was 37 (range = 21–63) years and was similar to the 71 controls. Among HIV-positive participants (26 cases and 67 controls), cases were independently associated with higher frequency of anal or oral sex (OR = 3.4; 95% CI = 1.4–8.6; increase per category from < 1/month, ≥ 1/month but < 1/week, to ≥ 1/week) and no or inconsistent condom use during anal or oral sex (OR = 3.0; 95% CI = 1.1–8.3; increase per category from using every time, occasionally, to never), adjusted for residency and time between visits. Discussion Modifiable behaviours were associated with incident syphilis, and dissemination of prevention messages are needed.