Background: We aimed to examine the accompanying and solo impacts of conditioned medium of human adiposederived stem cells (h-ASC-COM) and photobiomodulation (PBM) on the maturation stage of an ischemic infected delayed-healing wound model (IIDHWM) of rats with type 2 diabetes (TIIDM). Results: Outcomes of the wound closure ratio (WCR) results, tensiometrical microbiological, and stereological assessment followed almost identical patterns. While the outcomes of h-ASC-COM + PBM, PBM only, and h-ASCCOM only regimes were significantly better for all evaluated methods than those of group 1(all, p < 0.001), PBM alone and h-ASC-COM + PBM therapy achieved superior results than h-ASC-COM only (ranged from p = 0.05 to p < 0.001). In terms of tensiometrical and stereological examinations, the results of h-ASC-COM + PBM experienced better results than the PBM only (all, p < 0.001). Conclusions h-ASC-COM + PBM, PBM, and h-ASC-COM cures expressively accelerated the maturation stage in the wound healing process of IIDHWM with MRSA in TIIDM rats by diminishing the inflammatory reaction, and the microbial flora of MRSA; and increasing wound strength, WCR, number of fibroblasts, and new blood vessels. While the h-ASC-COM + PBM and PBM were more suitable than the effect of h-ASC-COM, the results of h-ASCCOM + PBM were superior to PBM only.

Anxiety, stress and depression are exceedingly comorbid psychological illnesses that the predominance will expand to the second most important risk of morbidity and sociodemographic burden. Due to several side-effects of chemical drugs, numerous specialists and patients prefer complementary herbal therapies like Ginkgo Biloba Extracts (GBE) to medicate the illnesses. In this review, we summarized the antidepressant, anxiolytic and antistress properties of GBE. We perceived that GBE could be beneficial for treatment of these disorders. Although experience of repeated studies on models and humans have proved reliability of antidepressant properties of GBE, further clinical trials are still required to validate the anti-stress and anti-anxiety effects of GBE on humans.