1.Design, synthesis, and biological evaluation of multiple targeting antimalarials.
Yiqing YANG ; Tongke TANG ; Xiaolu LI ; Thomas MICHEL ; Liqin LING ; Zhenghui HUANG ; Maruthi MULAKA ; Yue WU ; Hongying GAO ; Liguo WANG ; Jing ZHOU ; Brigitte MEUNIER ; Hangjun KE ; Lubin JIANG ; Yu RAO
Acta Pharmaceutica Sinica B 2021;11(9):2900-2913
Malaria still threatens global health seriously today. While the current discoveries of antimalarials are almost totally focused on single mode-of-action inhibitors, multi-targeting inhibitors are highly desired to overcome the increasingly serious drug resistance. Here, we performed a structure-based drug design on mitochondrial respiratory chain of
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