1.Inhibition of LIM kinase reduces contraction and proliferation in bladder smooth muscle.
Qingfeng YU ; Chengjie WU ; Yeda CHEN ; Bingsheng LI ; Ruixiao WANG ; Ru HUANG ; Xuechun LI ; Di GU ; Xiaolong WANG ; Xiaolu DUAN ; Shujue LI ; Yang LIU ; Wenqi WU ; Martin HENNENBERG ; Guohua ZENG
Acta Pharmaceutica Sinica B 2021;11(7):1914-1930
Overactive bladder (OAB) is the most bothersome symptom in lower urinary tract symptoms (LUTS). Current pharmacologic treatment aims to inhibit detrusor contraction; however, shows unsatisfied efficacy and high discontinuation rate. LIM kinases (LIMKs) promote smooth muscle contraction in the prostate; however, their function in the bladder smooth muscle remains unclear. Here, we studied effects of the LIMK inhibitors on bladder smooth muscle contraction and proliferation both
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