2.The role of PIVKA-II in hepatocellular carcinoma surveillance in an Asian population.
Wai Yoong NG ; Daniel Yan Zheng LIM ; Si Yu TAN ; Jason Pik Eu CHANG ; Thinesh Lee KRISHNAMOORTHY ; Chee Hooi LIM ; Damien Meng Yew TAN ; Victoria Sze Min EKSTROM ; George Boon Bee GOH ; Mark Chang Chuen CHEAH ; Rajneesh KUMAR ; Chin Pin YEO ; Chee Kiat TAN
Annals of the Academy of Medicine, Singapore 2023;52(2):108-110
3.Perception of disease, well-being and financial burden by patients with chronic hepatitis B: A self-reported assessment.
Ruojun DING ; Gayathry MORVIL ; Boon Bee George GOH ; Thinesh Lee KRISHNAMOORTHY ; Pei Yuh CHIA ; Hiang Keat TAN ; Victoria Sze Min EKSTROM ; Chang Chuen Mark CHEAH ; Jin Yang Terence TAN ; Pek Siang Edmund TEO ; Pik Eu Jason CHANG ; Chee Kiat TAN ; Xiaohui XIN ; Wan Cheng CHOW ; Rajneesh KUMAR
Annals of the Academy of Medicine, Singapore 2022;51(6):378-380
4.Global prevalence of metabolic dysfunction-associated fatty liver disease-related hepatocellular carcinoma: A systematic review and meta-analysis
Harry CRANE ; Guy D. ESLICK ; Cameron GOFTON ; Anjiya SHAIKH ; George CHOLANKERIL ; Mark CHEAH ; Jian-Hong ZHONG ; Gianluca SVEGLIATI-BARONI ; Alessandro VITALE ; Beom Kyung KIM ; Sang Hoon AHN ; Mi Na KIM ; Simone I STRASSER ; Jacob GEORGE
Clinical and Molecular Hepatology 2024;30(3):436-448
Background/Aims:
The global proportion of hepatocellular carcinoma (HCC) attributable to metabolic dysfunction-associated fatty liver disease (MAFLD) is unclear. The MAFLD diagnostic criteria allows objective diagnosis in the presence of steatosis plus defined markers of metabolic dysfunction, irrespective of concurrent liver disease. We aimed to determine the total global prevalence of MAFLD in HCC cohorts (total-MAFLD), including the proportion with MAFLD as their sole liver disease (single-MAFLD), and the proportion of those with concurrent liver disease where MAFLD was a contributary factor (mixed-MAFLD).
Methods:
This systematic review and meta-analysis included studies systematically ascertaining MAFLD in HCC cohorts, defined using international expert panel criteria including ethnicity-specific BMI cut-offs. A comparison of clinical and tumour characteristics was performed between single-MAFLD, mixed-MAFLD, and non-MAFLD HCC.
Results:
22 studies (56,565 individuals with HCC) were included. Total and single-MAFLD HCC prevalence was 48.7% (95% confidence interval [CI] 34.5–63.0%) and 12.4% (95% CI 8.3–17.3%), respectively. In HCC due to chronic hepatitis B, C, and alcohol-related liver disease, mixed-MAFLD prevalence was 40.0% (95% CI 30.2–50.3%), 54.1% (95% CI 40.4–67.6%) and 64.3% (95% CI 52.7–75.0%), respectively. Mixed-MAFLD HCC had significantly higher likelihood of cirrhosis and lower likelihood of metastatic spread compared to single-MAFLD HCC, and a higher platelet count and lower likelihood of macrovascular invasion compared to non-MAFLD HCC.
Conclusions
MAFLD is common as a sole aetiology, but more so as a co-factor in mixed-aetiology HCC, supporting the use of positive diagnostic criteria.
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