BACKGROUND

A “rejuvenating set” is composed of different skin products. A dilemma is that these are readily available despite containing active ingredients subject to regulation. There are several reports of side effects from use of these products.

OBJECTIVE

This study aimed to assess the knowledge, attitude, and practices on Rejuvenating sets among patients.

METHODS

This is a descriptive and observational study. Respondents answered a questionnaire covering the patient’s age, sex, educational attainment, occupation, monthly income, marital status, consumer behavior and preference in selection, side effects, habits, and practices of rejuvenating set use.

RESULTS

A total of 108 participated in this study. Majority belong to the age of 18-25 years old (42.9%), are female (65.7%), single (76.9%), and unemployed (73.3%). Sunscreen was the most common product used (51.4%). Advertisements in television was the most common factor considered during purchase (28.6%) and most were purchased at drugstores (30.5%). Majority of participants used rejuvenating sets daily (40%) for 1-3 months (32.4%). Most were unaware of the possible adverse effects (56.2%) and did not consult a physician prior to use (84.9%). There was a lack in knowledge on the composition of rejuvenating sets in terms of regulated ingredients (55.2%). A few reported signs and symptoms such as redness (33.3%), dryness (28.6%), and stinging (24.8%) after use.

CONCLUSION

This study serves as a tool to increase discourse on rejuvenating sets. With the rise in popularity and availability and lack of studies on the side effects, it is imperative that further similar studies be made.

Human ; Skin Care ; Dermatology

Epidermal nevus syndromes (ENS) are a group of complex disorders characterized by the presence of epidermal hamartomas in association with extracutaneous manifestations involving numerous organ systems. The diseases included within the spectrum of ENS are quite rare and specific molecular defects have been elucidated in only a few cases. An epidermal nevus syndrome with a mutation of the ZMYM2 gene has not been reported to the best of our knowledge.

This is a case of a 17-year-old female who presented at birth with prominent skeletal deformities and multiple erythematous verrucous papules and plaques in a blaschkoid distribution on the back and extremities, increasing in size and number as the patient grew. The patient was also noted to have delayed gross motor and speech milestones as well as marked mixed hearing loss on both ears. Histologic findings of the skin lesions were consistent with Verrucous Epidermal Nevus. Further imaging workups revealed the presence of bilateral diminutive kidneys. Whole exome sequencing by orthogonal method (Sanger sequencing) was performed revealing a likely pathogenic variant of the ZMYM2 gene, a gene which as of writing, has not been associated with any epidermal nevus syndrome.

We provide the first evidence of the possibility of involvement of the gene ZMYM2 in ENS. Considering the detected variant does not fully explain the patient’s phenotype, proceeding to genome sequencing and performing targeted testing by next generation sequencing on the affected tissue to assess the mosaicism of the detected variant is highly considered.

Human ; Female ; Adolescent: 13-18 Yrs Old