1.The Experiences of Pharmacists and Future Subjects in Regards to the Ingestion of Stable-Iodide Caused by the Fukushima Daiichi Nuclear Power Plant Accident
Kiyoko Endo ; Mariko Takahashi ; Emiko Kunugi ; Kazutaka Noguchi ; Masao Sato
Japanese Journal of Social Pharmacy 2014;33(1):43-50
The Fukushima Daiichi Nuclear Power Plant (FDNPP) Accident happened in Fukushima prefecture in March, 2011 and various efforts have been carried out to prevent health damage, including thyroid cancer, caused by radioactive-iodide. In this present report, we tried to discover whether stable-iodide for the prevention against the development of thyroid cancer was properly administered to radioactive-iodide-exposed persons or not. Since pharmacists play an important role in the treatment of stable-iodide, we investigated how the pharmacists in Fukushima contributed to the treatment of stable iodide in the FDNPP accident. In addition, we introduce a new revised method for the treatment of stable iodide published by the Nuclear Regulation Authority, discuss the important role of pharmacists in the Nuclear Power Plant Accident, and propose possible ways of preparation to protect the health of citizens.
2.Effects of Cigarette Smoking on Newborns and Infants in a Rural Community.
Rikako KOMATSU ; Akiko MIURA ; Eiko SATO ; Sachiko SASAKI ; Mariko ANBO ; Ryoko SATO ; Kazuo KOMATSU ; Toshihiro OKAMURA ; Kazuhiko TAKANO
Journal of the Japanese Association of Rural Medicine 1995;44(2):93-98
Many researchers report that cigarette smoking by parents adversely affects their children. We carried out a survey about cigarette puffing by distributing questionnaires to mothers of sucklings and little children. The survey found that mothers and family members were not well aware of the health consequences of passive smoking. It was also found that children frequently exposed to smoking are at high risk of contracting infections of the respiratory tract. The average weight at birth was less in babies borned by smoking mothers than by those who do not smoke. Furthermore, it was revealed that a larger number of smoking mothers had given birth to low birth weight infants than nonsmoking mothers had.
These findings suggested that passive cigarette smoking is linked to low birth weight and respiratory tract infection. We think it is incumbent on us, health-care professionals, to bring home to mothers and the rest of the family members how serious the consequences of passive smoking are.
3.Reliability and validity of Japanese version Caregiver Quality of Life Index-Cancer (CQOLC)
Saki Ando ; Mariko Harata ; Michael A Weitzner ; Mizuki Kuji ; Megumi Shimizu ; Kazuki Sato ; Mitsunori Miyashita
Palliative Care Research 2013;8(2):286-292
Purpose: This study was to examine both the reliability and validity of the Japanese version of the Caregiver Quality of Life Index-Cancer (CQOLC), which was developed to measure the quality of life of family caregivers of cancer patients. Methods & Results: Study subjects comprised 400 family caregivers who were registered at an Internet research company. The explanatory factor analysis yielded the following 4 domains: psychological burden (8 items); positive emotions (5 items); and financial burden (3 items); disruption of daily living (5 items). The Cronbach's alpha coefficients of the total score and each domain were 0.85 and 0.75 to 0.88, respectively. The total score and each domain were moderately correlated with mental health, vitality, social functioning, general health, role emotinal scores from the SF-36. The intraclass correlation coefficients of the total score and each domain were 0.78 and 0.67 to 0.74, respectively. Conclusion: These results suggest that the Japanese version of the CQOLC has sufficient reliability and validity.
4.Status-Que of Bronchial Asthma in Children in Akita Prefecture Report No.1, Present condition of bronchial asthma in elementary and junior high school pupils
Shioko Sasaki ; Akiko Miura ; Hisako Yoshida ; Sachiko Sasaki ; Mariko Anbo ; Makiko Konno ; Kieko Sasaki ; Machiko Takahashi ; Mariko Tanaka ; Toshihiro Okamura ; Hiroaki Sato
Journal of the Japanese Association of Rural Medicine 1984;32(5):964-968
Our survey was conducted at 522 elementary schools and junior high schools in Akita prefecture in July 1981. Thus the survey was intended for 105, 137 elementary school pupils bnd 51, 029 junior high school pupils. Questionnaires were sent to teachers in charge at each school. The return rate of questionnaires wan 98.4 % for elementary school and 100.0 % for junior high school. The rate of bronchial asthma was 1.2 %(boy 1.5 %, girl 0.9 %) in elementary school pupils and 0.6 %(boy 0.8 %, girl 0.5 %) in junior high school pupils. The number of schools where pupils with bronchial asthma were found was 205 elementary schools (56.0 %) and 71 junior high schools (47.0 %). The rate of bronchial asthma in boys was greater than girls, by 1.7 times in case of elementary school and 1.6 times in junior high school. The rate of bronchial asthma in urban children was 1.2 %, while that in rural children was 0.8 %. Out of the children interpreted as bronchial asthma at the time of our survey 82.4 % of the elementary school children and 77.6 % of the junior high school children with bronchial asthma were or had been undergoing apropriate treatment. The rate of children who are absent from school due to asthma more than 10 days a year was 24.4 % in elementary school and 26.7 % in junior high school.
5.Personal growth and related factors among family primary caregivers after bereavement of a terminally ill cancer patient at home
Tomomi Sano ; Etsuko Kusajima ; Yuki Shirai ; Mariko Setoyama ; Terue Tamai ; Kayo Hirooka ; Takahiro Sato ; Mitsunori Miyashita ; Masako Kawa ; Takeshi Okabe
Palliative Care Research 2014;9(3):140-150
Purpose: To identify the nature of personal growth of family primary caregivers after bereavement and to explore the association between such growth and the experience of caring for a terminally ill cancer patient at home. Methods: A self-administered questionnaire survey was mailed to 112 bereaved family primary caregivers who, with assistance from a palliative care service, had cared for a terminally ill cancer patient at home. The main outcomes were measured using the After Bereavement Growth Inventory, previously developed. Results: Responses from 73 questionnaires were analyzed (effective response rate, 66%). The post-bereavement growth score was significantly higher among the study group than among the general population who had experienced bereavement due to illness-related death. Multiple regression analysis revealed that post-bereavement growth was more likely to occur among those family members who, "at the time they chose to provide home palliative care, intended to care for a patient at home until the time of death" and when "the patient desired home palliative care", those who "felt a deepening of their bond with the patient", and those who "felt the death was peaceful". Conclusion: Our findings suggest that for primary family caregiver's to experience personal growth after bereavement, medical professionals should support patients' preference of place at the end of life and caregivers' preparation for the expected home death, respect the family's bond with the patient, and through appropriate symptom management in home palliative care to maintain the patient's sense of peacefulness until the end of life.
6.Mass Survey for Diabetes Mellitus by a Glucose Tolerance Test (GTT) as the First Screening
Shioko Sasaki ; Akiko Miura ; Hisako Yoshida ; Sachiko Sasaki ; Mariko Saito ; Makiko Konno ; Kieko Sasaki ; Machiko Takahashi ; Mariko Tanaka ; Chiyuki Nakanome ; Waichi Sato ; Norihiko Moriai ; Kanji Komatsu ; Kiichi Kaishio ; Masaaki Inomata ; Koichiro Miura
Journal of the Japanese Association of Rural Medicine 1983;31(5):753-758
We have carried out the mass survey for diabetes mellitus by a 50 g GTT as the first screening since 1971. Average incidences of diabetic pattern, IGT pattern, borderline pattern and normal pattern in a Glucose Tolerance Test (GTT) were 2.3±1.8%, 6.6±1.7%, 19.8±6.6% and 71.4 ±7.8%, respectively. 21 males and 6 females were found to be diabetic by this survey for 11 years. Insulinogenic indices (I. Is.) of diabetic, IGT, borderline and normal patterns were 0.13±0.07, 0.70±0.37, 0.58±0.40 and 1.05±0.30, respectively, and the values of I. I. in diabetics and borderline diabetics were significantly lower than that in the normal pattern. A I. I. in the subjects who have revealed the normal glucose tolerance every year for 11 year, 2.62±1.28, was high in the normal range. On the other hand, a I. I. in the subjects who became overtly diabetic from the IGT, borderline or normal pattern, 0.36±0.31, was significantly lower. Therefore, taking into consideration that one of the characteristics of NIDDM is low insulin response to glucose, the mass survey for diabetes mellitus should be carried out by a Glucose Tolerance Test (GTT) as the first screening with the measurement of plasma insulin concentrations. A follow-up study for the low insulin responder is considered to be one of the most preferable investigations for the detection of the early stage of diabetes mellitus.
7.Characteristics of Falls and Falling Patients in an Acute Hospital
Mizuki SATO ; Tomoko TAKAHASHI ; Noritaka SAKATA ; Mariko TAKAHASHI ; Hiroaki UOZUMI ; Tomoya OMAE
Journal of the Japanese Association of Rural Medicine 2019;68(4):510-516
JA Omagari Kosei Medical Center is an acute hospital located in Daisen City, Akita Prefecture, and we have two comprehensive community-based care wards. Falls and fall incidents are always ranked high in acute hospitals. Injuries caused by falls such as fracture, may lead to decline in activities of daily living / quality of life in patients and / or their families, which may then prolong the hospitalization period. Therefore, prevention of falls and falling is beneficial. Previous studies have reported that the activities of the ‘falls and falling’ teams contribute to reducing the fall rate. However, few studies have been conducted in acute hospital settings. Therefore, in this study we summarized the characteristics and current status of hospitalized patients in terms of falls and falling incidents in our hospital from medical records and incident accident reports. Among 230 patients, 291 falls and falling incidents were reported in 1 year; falls and falling accounted for 32.9% of all incidents. In addition, the fall rate was 2.1 cases / 1,000 patients / day, average age was 77 years, and there was a higher tendency in men. Furthermore, falls and falling occurred on a median 13 days from hospitalization; in 124 cases (42.6%) within 10 days after hospitalization and in 60 cases (20.6%) from 10 days to 20 days. A similar tendency was seen in patients who were moved to the comprehensive community-based care ward. Therefore, we considered that the patient would require continuous attention after moving to that ward. Ultimately, falls and falling occurred in the late-night period (from midnight to 8 a.m.), and many were at the bedside (58.4%), and the purpose of movement was bowel motion (54.3%).
8.A Practical Grading Scale for Predicting Outcomes of Radiosurgery for Dural Arteriovenous Fistulas: JLGK 1802 Study
Hirotaka HASEGAWA ; Masahiro SHIN ; Jun KAWAGISHI ; Hidefumi JOKURA ; Toshinori HASEGAWA ; Takenori KATO ; Mariko KAWASHIMA ; Yuki SHINYA ; Hiroyuki KENAI ; Takuya KAWABE ; Manabu SATO ; Toru SERIZAWA ; Osamu NAGANO ; Kyoko AOYAGI ; Takeshi KONDOH ; Masaaki YAMAMOTO ; Shinji ONOUE ; Kiyoshi NAKAZAKI ; Yoshiyasu IWAI ; Kazuhiro YAMANAKA ; Seiko HASEGAWA ; Kosuke KASHIWABARA ; Nobuhito SAITO ;
Journal of Stroke 2022;24(2):278-287
Background:
and Purpose To assess the long-term outcomes of intracranial dural arteriovenous fistula (DAVF) treated with stereotactic radiosurgery (SRS) alone or embolization and SRS (Emb-SRS) and to develop a grading system for predicting DAVF obliteration.
Methods:
This multi-institutional retrospective study included 200 patients with DAVF treated with SRS or Emb-SRS. We investigated the long-term obliteration rate and obliteration-associated factors. We developed a new grading system to estimate the obliteration rate. Additionally, we compared the outcomes of SRS and Emb-SRS by using propensity score matching.
Results:
The 3- and 4-year obliteration rates were 66.3% and 78.8%, respectively. The post-SRS hemorrhage rate was 2%. In the matched cohort, the SRS and Emb-SRS groups did not differ in the rates of obliteration (P=0.54) or post-SRS hemorrhage (P=0.50). In multivariable analysis, DAVF location and cortical venous reflux (CVR) were independently associated with obliteration. The new grading system assigned 2, 1, and 0 points to DAVFs in the anterior skull base or middle fossa, DAVFs with CVR or DAVFs in the superior sagittal sinus or tentorium, and DAVFs without these factors, respectively. Using the total points, patients were stratified into the highest (0 points), intermediate (1 point), or lowest (≥2 points) obliteration rate groups that exhibited 4-year obliteration rates of 94.4%, 71.3%, and 60.4%, respectively (P<0.01).
Conclusions
SRS-based therapy achieved DAVF obliteration in more than three-quarters of the patients at 4 years of age. Our grading system can stratify the obliteration rate and may guide physicians in treatment selection.
9.Evaluation and Interpretation of 9 Body Constitution Scores of CCMQ-J by Seven Independent Questionnaires
Guang SHI ; Hoko KYO ; Toshihiro KAWASAKI ; Shigehiko KANAYA ; Mariko SATO ; Saki TOKUDA-KAKUTANI ; Hiroshi WATANABE ; Norihito MURAYAMA ; Minako OHASHI ; Md ALTAF-UL-AMIN ; Naoaki ONO ; Hiroki TANAKA ; Satoshi NAKAMURA ; Kazuo UEBABA ; Nobutaka SUZUKI ; Ming HUANG
Japanese Journal of Complementary and Alternative Medicine 2019;16(2):79-93
In this study, we proposed an approach to interpret the classification of body constitution based on the Japanese Version of Constitution in Chinese Medicine Questionnaire (CCMQ-J) in terms of an augmented questionnaire combining seven independent questionnaires. The augmented questionnaire consists of 254 questions in terms of seven categories of attributes, which are the (i) basic information (BI), (ii) disease (DI), (iii) social factors (SO), (iv) mental factors (ME), (v) dietary habits (DH), (vi) sleeping state (SL), and (vii) sub-health (SH). The partial least square (PLS) regression has been adopted to model the correlations between the scores of body constitutions and the questions, and their results show that the body constitution can be represented by the linear combination of the questions substantially (correlation coefficients between the true and predicted constitutions are all above 0.7). Moreover, by using the crowdsourcing technique in data collection, a total of 851 samples (350 males and 501 females between 20 and 85 years old) samples with diverse geographical backgrounds in Japan have been collected, from which new medical implications have been extracted through the discussion in a Traditional Chinese Medicine standpoint. This study serves as a crucial step for validating the philosophy of ancient Chinese medicine by the state-of-the-art information science techniques and facilitating the use of the CCMQ-J in public healthcare.
10.Determination of Optimum Number of Groups on the Crowdsourcing Survey in Japanese People Interpreted by Physical Constitution Defined by CCMQ-J
Mariko SATO ; Toshihiro KAWASAKI ; Ming HUANG ; Hoko KYO ; Naoaki ONO ; Ryouhei EGUCHI ; Md. ALTAF-UL-AMIN ; Saki TOKUDA-KAKUTANI ; Hiroshi WATANABE ; Norihito MURAYAMA ; Satoshi NAKAMURA ; Shiori YAMAGUCHI ; Hiroki TANAKA ; Shigehiko KANAYA ; Yanbo ZHU ; Zhaoyu DAI ; Qi WANG ; Kazuo UEBABA ; Nobutaka SUZUKI
Japanese Journal of Complementary and Alternative Medicine 2019;16(2):105-112
Chinese Medicine Questionnaire (CCMQ-J) consists of sixty independent questionnaires and 9 physical constitutions called subscales. One type is balanced constitution (i.e., gentleness), and the following eight types represent unbalanced constitution: Qi-deficiency constitution, Yang-deficiency constitution, Yin-deficiency constitution, Phlegm-dampness constitution, Damp-heat constitution, Stagnant Blood constitution, Stagnant Qi constitution, and Inherited Special constitution. In this study, we proposed to determine optimal number of groups in 851 participants recruited from crowdsourcing answered CCMQ-J questionnaire consisting of 60 questions. In the present study, we applied k-means clustering with gap statistics to the questionnaire data and the number of optimal groups was estimated by five. The five groups are mainly characterized by 3 subscales in CCMQ-J, i.e. (i) two subscales corresponding to Yang-deficiency and Qi-depress, (ii) three subscales corresponding to gentleness, Yang-deficiency and Qi-depress (iii) Yang-deficiency, (iv) gentleness, and (v) Qi-depress. In the crowdsourcing survey, two subscales, Yang-deficient and Qi-depress are the most frequently occurred in current Japanese people.