Introduction: We investigated the end-of-life care preferences of patients with mild dementia and compared them with the hopes of caregivers regarding end-of-life care for patients.Methods: A questionnaire survey was conducted among outpatients with mild dementia or mild cognitive impairment and their family caregivers who visited the Medical Center for Dementia.Results: We analyzed 50 pairs of dementia patients and their family caregivers. Of people with dementia, 24 respondents (48.0%) preferred "antibiotics and infusions for pneumonia" at the end of life. Eleven respondents (22.0%) preferred "central parenteral nutrition". Eight respondents (16.0%) preferred "resuscitation". For each end-of-life care item, the concordance rate between patients and caregivers on "prefer" / "do not prefer" was 0%-76%. Patients and their families who discussed end-of-life care had a significantly higher concordance rate for "resuscitation" preference than those who did not.Conclusion: For patients and their families to be able to make decisions they do not regret, it is important to promote discussions about end-of-life medical care before the patient's condition becomes severe.

The purpose of this study was to determine if salivary chromogranin a secretion in dogs exhibits a circadian rhythm. Saliva sampling was performed during three different sessions occurring in three nonconsecutive 24-h periods. Sixteen healthy adult beagle dogs (8 males and 8 females) were moved to a sampling room and housed individually in cages. Saliva samples were obtained every 4 h from 12:00 p.m. to 12:00 p.m. the following day. In the interest of habituation, saliva was obtained hourly from each dog 3 h before the experiment was started. Salivary chromogranin A concentrations were measured using an enzyme-linked immunosorbent assay. No circadian rhythm was detected for salivary chromogranin A secretion, and no differences in salivary chromogranin A concentrations measured every 4 h were demonstrated during the 24-h cycle in dogs.
Animals ; Chromogranin A/*analysis/*metabolism ; *Circadian Rhythm ; Dogs/*physiology ; Saliva/*chemistry