1.Testosterone decreases adiponectin levels in female to male transsexuals.
Marta BERRA ; Francesca ARMILLOTTA ; Laura D'EMIDIO ; Antonietta COSTANTINO ; Giuseppe MARTORANA ; Giuseppe PELUSI ; Maria Cristina MERIGGIOLA
Asian Journal of Andrology 2006;8(6):725-729
AIMTo evaluate the effect of testosterone (T) on adiponectin serum levels in transsexual female patients.
METHODSWe measured adiponectin, leptin, luteinizing hormone and follicle stimulating hormone, T, estradiol, lipid profile, biochemical parameters and body composition in 16 transsexual female patients at baseline and after 6 months of T treatment (100 mg Testoviron Depot /10 days, i.m.).
RESULTSAdiponectin levels were 16.9 +/- 7.3 mg/mL at baseline and 13.5 +/- 7.4 mg/mL at month 6 of T treatment (P < 0.05). Leptin and high-density lipoprotein cholesterol decreased significantly, whereas body mass index, waist circumference and lean body mass increased significantly after 6 months of T treatment. No changes in insulin or Homeostasis Model Assessment were detected.
CONCLUSIONT can significantly reduce adiponectin serum levels in transsexual female patients.
Adiponectin ; secretion ; Adipose Tissue ; drug effects ; Adult ; Body Mass Index ; Body Weight ; drug effects ; Cholesterol ; blood ; Cholesterol, HDL ; blood ; Cholesterol, LDL ; blood ; Female ; Humans ; Leptin ; blood ; Sex Hormone-Binding Globulin ; metabolism ; Testosterone ; blood ; therapeutic use ; Transsexualism ; drug therapy
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