1.Efficacy of repetitive transcranial magnetic stimulation (rTMS) in inducing weight loss among obese Filipino patients
Margaret Encarnacion ; Oliver Allan Dampil ; Ludwig Damian ; Maria Leila Doquenia ; Divina Cristy Redondo-Samin ; Mary Karen Woolbright
Journal of the ASEAN Federation of Endocrine Societies 2020;35(2):181-189
Objective. To determine the efficacy of rTMS in decreasing body mass index (BMI) versus sham stimulation among obese Filipino patients.
Methodology. This was a single-center, randomized, sham-controlled, single-blind, parallel group trial. Participants were 15-65 years old with BMI ≥30 kg/m2 and weight stable for 6 weeks. Participants were randomized to receive real rTMS or sham stimulation. Each underwent 4 sessions of stimulation over 2 weeks. Anthropometrics, total caloric intake (TCI), and VAS score for appetite were taken at baseline, 2, 4, 6, and 12 weeks.
Results. A total of 31 patients were randomized with 15 to the treatment and 14 to sham stimulation completing treatment, with 2 lost to follow-up. A significant decrease in BMI was noted after 4 weeks from the start of rTMS in the treatment group, (0.6±0.6, p-value=0.001), with weight change of -1.3±1.3 kg (p-value=0.009), but was no longer observed at 6 weeks onwards. No severe adverse effects were noted.
Conclusion. rTMS to the DLPFC effectively decreased BMI (0.6±0.6) and weight (-1.3±1.3 kg) from baseline to 4 weeks. At 6-12 weeks after rTMS however, there was no longer a significant difference, indicating that 4 sessions of rTMS may not be enough to produce a prolonged effect on weight loss.
weight loss
;
obesity
;
Transcranial Magnetic Stimulation
2.Comparison of clinical outcomes and presence of nephropathy and/or retinopathy among type 2 diabetes mellitus patients with obesity and overweight versus those with normal Body Mass Index: A cross-sectional study
Jennifer Lourdes Ng ; Janine Audrei Pajimna ; Margaret Encarnacion-Fernandez ; Sweet Garllie Albert Tappan ; Gabriel Jasul Jr ; Oliver Allan Dampil
Philippine Journal of Internal Medicine 2024;62(2):100-105
Background:
This study aimed to determine the differences in glycemic control, metabolic parameters (blood pressure
control, triglycerides, LDL, HDL) and the presence of nephropathy and/or retinopathy between obese and overweight
versus normal body mass index (BMI) type 2 diabetes mellitus patients (T2DM).
Methodology:
This is an analytic cross-sectional study of T2DM patients from outpatient clinics at St. Luke’s Medical Center,
Quezon City. Available medical records and laboratory tests were reviewed. Data were analyzed and compared between
those overweight and obese versus those with normal BMI based on Asia Pacific Guidelines.
Results:
A total of 248 patients with T2DM were included in the study. More patients who are obese and overweight have
uncontrolled diabetes (p = 0.011), low HDL (p = 0.037) and nephropathy (p = 0.027) compared to those with normal BMI.
There were no significant difference between overweight and obese patients versus those with normal BMI with regards to
BP control, high LDL, high triglycerides and retinopathy.
Conclusion
T2DM patients who are obese and overweight have a significantly higher prevalence of uncontrolled diabetes,
low HDL and nephropathy compared to those with normal BMI.
Diabetes Mellitus
;
Overweight