1.No Effect of Serotoninergic Gene Variants on Response to Interpersonal Counseling and Antidepressants in Major Depression.
Alessandro SERRETTI ; Chiara FABBRI ; Silvia PELLEGRINI ; Stefano PORCELLI ; Pierluigi POLITI ; Silvio BELLINO ; Marco MENCHETTI ; Veronica MARIOTTI ; Cristina DEMI ; Valentina MARTINELLI ; Marco CAPPUCCIATI ; Paola BOZZATELLO ; Elena BRIGNOLO ; Paolo BRAMBILLA ; Chi Un PAE ; Matteo BALESTRIERI ; Diana DE RONCHI
Psychiatry Investigation 2013;10(2):180-189
OBJECTIVE: Gene variants within the serotonin pathway have been associated with major depressive disorder (MDD) treatment outcomes, however a possible different modulation on pharmacological or psychological treatments has never been investigated. METHODS: One hundred sixty MDD patients were partially randomized to either inter-personal counseling (IPC) or antidepressants. The primary outcome was remission at week 8. Five serotonergic polymorphisms were investigated (COMT rs4680, HTR1A rs6295, HTR2A rs2224721, HTR2A rs7997012 and SLC6A4 rs421417). RESULTS: IPC (n=43) and antidepressant (n=117) treated patients did not show any difference in remission rates at week 8 (corrected for baseline severity, age and center). None of the studied gene variants impacted on response and remission rates at week 8 neither in the IPC nor in the antidepressant group. An analysis of the whole sample showed a trend of association between rs7997012 AA genotype and a better treatment outcome. CONCLUSION: Our study confirms that IPC is an effective psychological intervention comparable to antidepressants in mild-moderate MDD. Polymorphisms related to the serotonin system did not exert a major effect on clinical outcomes in none of the treatment groups.
Antidepressive Agents
;
Counseling
;
Depression
;
Depressive Disorder, Major
;
Genotype
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Humans
;
Psychotherapy
;
Receptor, Serotonin, 5-HT1A
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Receptor, Serotonin, 5-HT2A
;
Serotonin
;
Serotonin Plasma Membrane Transport Proteins
Result Analysis
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