Objective To study the efficacy of Yunnan baiyao aerosol treatment for patients undergone percutaneous coronary intervention ( PCI) with subcutaneous hematoma .Methods Seventy patients undergone PCI with subcutaneous hematoma were chosen as the research objects and divided into the observation group (35 cases) and the control group (35 cases) according to the order of odd or even number of patients enrolled . The patients in the observation group were treated with Yunnan baiyao aerosol plus Yunnan baiyao aerosol insurance solution, and those in the control group were treated with wet dressing of magnesium sulfate (50%). The treatment effects , healing time and degree of pain relief of the two groups were compared .Results The total efficiency of the observation group was 97.1%, which was significantly better than 85.7 of the control group (χ2 =11.893, P<0.05).The healing time of the observation group was (3.6 ±0.8) days, which was significantly shorter than (5.3 ±1.1) days in the control group (t=7.382, P<0.05).After 3 days of the treatment, 4 patients in the observation group and 13 patients in the control group had the severe pain .The difference of the degree of pain relief between the observation group and the control group was statistically significant ( Z =-7.432, P <0.05 ).Conclusions Yunnan baiyao aerosol treatment to subcutaneous hematoma after PCI can rapidly and safely relieve pain , swelling and stasis .It can be operated and accepted by patients easily .And it is worthy of clinical application .