With the rapid development of early diagnosis and cardiac surgery technology, the survival rate of children with congenital heart disease ( CHD ) was improved; survival time was prolonged, and the quality of life drew more and more attention. This article summarizes the internal and external influencing factors that affect the quality of life of children with CHD, in order to know better about the influencing factors of quality of life in children with CHD, and provides the intervention basis for the children with CHD.