Objective To make drilling mechanical and thermal analysis of bones with different drill bits and drilling parameters, so as to reduce the drilling force and drilling temperature in drilling process and decrease the damage to surrounding bone tissues. Methods The bone drilling model was established by finite element simulation software AdvantEdge. By comparison with the pig femur drilling experiment, the simulated and experimental results of standard twist driII and three standard multi-facet drills at different speeds and feed rates were analyzed. Results The simulation and experiment comparison showed that the influences of driII bit structure, drilling speed, feed rate on drilling force and drilling temperature were consistent, and the established simulation model was credible. Conclusions Under the same drilling conditions, the multi-facet driII for drilling rubber had lower drilling force and drilling temperature than the standard twist drill. The research findings provide theoretical basis for the application of multi-facet driII in fracture surgery.