1.The bacteriostatic effect of four kinds of traditional Chinese herbal medicines on strains of extensively drug-resistant Acinetobacter baumannii
Xianli WU ; Zaiyuan PANG ; Maocheng AO
International Journal of Laboratory Medicine 2016;37(8):1030-1031,1034
Objective To investigate the bacteriostatic effect of 4 kinds of traditional Chinese herbal medicine on extensively drug‐resistant A .baumannii(XDRAB) bacteriostatic effect ,find a new way for the clinical treatment of the XDRAB infection .Meth‐ods The minimal inhibitory concentrations(MICs) of scutellaria ,forsythia ,rhizoma coptidis ,honeysuckle were determined by using broth two‐fold dilution method .Results The mean values of MICs of scutellaria ,forsythia ,rhizoma coptidis ,honeysuckle were 30 .99 ,187 .50 ,27 .61 and 75 .00 mg/mL ,respectively .Among the 4 kinds of traditional Chinese herbal medicines ,rhizoma coptidis got the strongest antimicrobial effect strongest inhibitory effect .There was no significant difference in the inhibitory effect of the strains collected from local or nonlocal(P>0 .05) .Conclusion The 4 kinds of Chinese herbal medicine had in vitro antibacterial ac‐tivity to XDRAB in different degree.
2.Synthesis and antifungal activities of novel triazole derivatives
Maocheng WU ; Xiang LI ; Qiuye WU
Journal of Pharmaceutical Practice 2014;(3):186-190
Objective To synthesize a new series of triazole compounds with naphthalene benzyl as side chain and evaluate the antifungal activity .Methods Nine title compounds were synthesized and determined by the 1 H NMR and MS spectra .According to the method recommended by the national committee for clinical laboratory standards (NCCLS), the RPMI-1640 test medium was used, the antifungal activities of all the compounds were evaluated against eight human pathogenic fungi in vitro.Results The title com-pounds exhibited potent antifungal activities .Compound 1c showed high activities against 7 funguses except Aspergillus fumigatus with the MIC80 values less than 0.125μg/ml, which was 16 times higher than that of Voriconazole .Conclusion The title compounds with naphthalene and alkyl substituent showed potent antifungal activities .
3.Research progress of inhibitors of peptides and peptidomimetic acting on P 53-MDM2 i nte rf ace
Xiang LI ; Yan ZOU ; Maocheng WU ; Ting HUANG ; Honggang HU ; Qiuye WU
Journal of Pharmaceutical Practice 2015;(6):494-497,512
Tumor diseases have attracted great attention of the society because of the increasing morbidity in recent years .To inhibit the P53-MDM2 interaction has become an important target for design of cancer drug ,and a lot of peptide and small molecule inhibitors have been found with various kinds of drug screening and research tools .This paper summarized the recent progress of the peptide and peptidomimetic inhibitors of P53-MDM2 at home and abroad lately .
4.Anatomical observation on oral part of the facial artery and facial vein and its clinical application
Dongqin YANG ; Lei YU ; Huan BIAN ; Feng TANG ; Yang TAN ; Xueqin BAI ; Yating FU ; Yuexuan HU ; Lan HUANG ; Jing CHEN ; Longhai WU ; Jingping ZHANG ; Yan ZENG ; Xiaobo WANG ; Maocheng RAN
Journal of Regional Anatomy and Operative Surgery 2015;(3):267-269
Objective To observe the oral part of the facial artery and facial vein and to provide anatomical data for clinical applica-tion. Methods The origin, branches, course, diameter, position of oral part of facial artery and facial vein were observed on 32 fixed cada-ves (64 sides). Results The position relation between the facial artery and facial vein is non-constant. Measure the distance from inferior border of mandible to corner of the mouth, angulus mandibulae, mental protuberance midpoint. It is (5. 49 ± 0. 63) cm, (2. 50 ± 0. 89) cm and (6. 20 ± 1. 68) cm in the left side respectively, and (5. 69 ± 0. 72) cm, (2. 56 ± 1. 08) cm and (6. 85 ± 1. 86) cm in the right side re-spectively. The diameter of facial artery in inferior border of mandible is (0. 33 ± 0. 08) cm in the left side and (0. 38 ± 0. 07) cm in the right side;while the diameter of facial vein is (0. 40 ± 0. 12) cm in the left side and (0. 42 ± 0. 18) cm in the right side. The facial artery and facial vein are not concomitant and they are not asymmetry also. The position of superior labial artery arteries is constant, but the position of inferior labial artery arteries have more variations. Conclusion The branches, course, diameter and position of oral part of facial artery and facial vein have a number of variations. The superior labial artery arteries could be positioned more easily than inferior labial artery arter-ies. Being familiar with their distribution is of great importance for clinical application.