Objective:To compare the clinical effect of dydrogesterone and progesterone in the treatment of threatened abortion.Methods:From March 2015 to May 2017, 50 patients with threatened abortion admitted in the Maternal and Child Health Hospital of Ninghai County were selected and randomly divided into two groups according to the digital table, with 25 cases in each group.The control group was treated with progesterone.The observation group was treated with dydrogesterone.The hormone levels, symptom disappearance time, fetal retention and adverse drug reactions were compared between the two groups.Results:One week after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (1 12.65±6.35)nmol/L, (2 137.99±371.22)pmol/L, (4 261.54±245.55)IU/L, respectively, which in the control group were (101.56±5.32)nmol/L, (1 782.12±350.71)pmol/L, (3 642.26±210.20)IU/L, respectively, the differences between the two groups were statistically significant ( t=6.694, 3.484, 9.581, all P<0.05). Three weeks after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (120.52±10.59)nmol/L, (2 240.68±409.06)pmol/L, (102.64±9.64)nmol/L, and (6 641.52±364.59)IU/L, respectively, which in the control group were (102.64±9.64)nmol/L, (1 921.76±371.07)pmol/L, (4 123.63±258.62)IU/L, respectively, the differences between the two groups were statistically significant( t=6.243, 2.887, 28.164, all P<0.05). Five weeks after treatment, the levels of progesterone, estradiol and human chorionic gonadotropin in the observation group were (134.15±17.16)nmol/L, (2 317.58±434.97)pmol/L, and (8 456.51±459.52)IU/L, respectively, which in the control group were (109.56±8.54)nmol/L, (2 051.38±413.39)pmol/L, (6 416.36±261.31)IU/L, respectively, the differences between the two groups were statisticallysignificant ( t=6.414, 2.218, 19.297, all P<0.05). The disappearance time of pain in the waist, abdominal pain and vaginal bleeding in the observation group was (4.15±0.25)d, (3.10±0.52)d, (4.24±0.62)d, respectively, which was shorter than that in the control group[(7.54±2.26)d, (4.31±1.10 d), (6.32±2.01)d]( t=7.455, 4.972, 4.944, all P<0.01). The success rate of fetal preservation in the observation group was 96.00%(24/25), which was higher than that in the control group[72.00%(18/25)](χ 2=5.357, P<0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups( P>0.05). Conclusion:The effect of dydrogesterone in the treatment of threatened abortion is better than progesterone.

Objective To evaluate the application effect of a novel hemodialysis catheter fixing strap in clinical hemodialysis.Methods A total of 199 hemodialysis patients from the Second Affili-ated Hospital of Anhui Medical University between May and July 2023 were enrolled in this study.Employing the self-controlled study design,patients were initially fixed with conventional adhesive tape(fixation method A)for their dialysis tubing from May 20 to June 20,2023.Subsequently,from June 21 to July 21,2023,patients were transitioned to a novel hemodialysis catheter fixing belt(fixa-tion method B)for the fixation of their dialysis tube.The incidence of puncture needle,central ve-nous catheter displacement,the stability of fixation,and the satisfaction levels of nurses and patients were compared between the two fixation methods.Results The rate of puncture needle/central ve-nous catheter displacement with method B was significantly lower than that with method A(P＜0.001).No statistically significant difference was observed in the puncture needle/central venous catheter displacement between the two methods(P＞0.05).The stability of fixation with method B was significantly higher than that with method A(P＜0.001).Patients'satisfaction with fixation method B(in favor of mobility and comfort)was significantly higher than that with fixation method A(P＜0.001);similarly,nurses'satisfaction with fixation method B(in favor of cleaning and convenient operation)was markedly superior to that with fixation method A(P＜0.001).Conclusion Compared with the traditional adhesive tape fixation method,the novel hemodialysis catheter securing strap effectively secures the catheter with improved safety and significantly enhances the satisfaction of both nurses and patients.

Objective To evaluate the application effect of a novel hemodialysis catheter fixing strap in clinical hemodialysis.Methods A total of 199 hemodialysis patients from the Second Affili-ated Hospital of Anhui Medical University between May and July 2023 were enrolled in this study.Employing the self-controlled study design,patients were initially fixed with conventional adhesive tape(fixation method A)for their dialysis tubing from May 20 to June 20,2023.Subsequently,from June 21 to July 21,2023,patients were transitioned to a novel hemodialysis catheter fixing belt(fixa-tion method B)for the fixation of their dialysis tube.The incidence of puncture needle,central ve-nous catheter displacement,the stability of fixation,and the satisfaction levels of nurses and patients were compared between the two fixation methods.Results The rate of puncture needle/central ve-nous catheter displacement with method B was significantly lower than that with method A(P＜0.001).No statistically significant difference was observed in the puncture needle/central venous catheter displacement between the two methods(P＞0.05).The stability of fixation with method B was significantly higher than that with method A(P＜0.001).Patients'satisfaction with fixation method B(in favor of mobility and comfort)was significantly higher than that with fixation method A(P＜0.001);similarly,nurses'satisfaction with fixation method B(in favor of cleaning and convenient operation)was markedly superior to that with fixation method A(P＜0.001).Conclusion Compared with the traditional adhesive tape fixation method,the novel hemodialysis catheter securing strap effectively secures the catheter with improved safety and significantly enhances the satisfaction of both nurses and patients.