1.Anti-tumor activities and apoptotic mechanism of ribosome-inactivating proteins.
Meiqi ZENG ; Manyin ZHENG ; Desheng LU ; Jun WANG ; Wenqi JIANG ; Ou SHA
Chinese Journal of Cancer 2015;34(8):325-334
Ribosome-inactivating proteins (RIPs) belong to a family of enzymes that attack eukaryotic ribosomes and potently inhibit cellular protein synthesis. RIPs possess several biomedical properties, including anti-viral and anti-tumor activities. Multiple RIPs are known to inhibit tumor cell proliferation through inducing apoptosis in a variety of cancers, such as breast cancer, leukemia/lymphoma, and hepatoma. This review focuses on the anti-tumor activities of RIPs and their apoptotic effects through three closely related pathways: mitochondrial, death receptor, and endoplasmic reticulum pathways.
Animals
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Antineoplastic Agents
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Apoptosis
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Endoplasmic Reticulum
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Humans
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Mitochondria
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Plant Proteins
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Receptors, Death Domain
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Ribosome Inactivating Proteins
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Ribosomes