1.A new connotation of neutrophil extracellular traps and bronchial asthma pathogenesis based on the basic principles of traditional Chinese medicine constitution
Yuhan ZONG ; Manting WANG ; Fan YANG ; Jingwei KONG ; Ji WANG
Journal of Beijing University of Traditional Chinese Medicine 2024;47(5):699-703
Bronchial asthma(asthma)is a common clinical respiratory disease mediated by multiple cells and components,and neutrophils,as one of the classic innate immune cells,play an important role in the pathogenesis of asthma.In the inflammatory state,neutrophils release neutrophils extracellular trap(NET)into the periphery through the NETosis procedure.Although NET is a beneficial antibacterial defense structure,its excessive accumulation can trigger different response mechanisms that can also adversely affect the lungs and exacerbate asthma.Based on the basic principles of traditional Chinese medicine constitution,exploring the important role of NET in the pathogenesis of asthma,it holds that the life process theory body-spirit composition theory,endowment inheritance theory,and environmental constraint theory are related to the gradual formation of NET and different stimuli affect the heterogeneity of NET,thereby mediating different biological effects during the onset of asthma.Targeting NET and/or its components may become a new treatment strategy on asthma.
2.Application of shear wave elastography in cervical cancer
Manting ZENG ; Jihua LIU ; Ningbo ZHOU ; Jian WANG ; Xuanxuan LI ; Hong ZHU
Journal of International Oncology 2019;46(2):117-120
Shear wave elastography (SWE) is used to quantitatively analyze the hardness of the tissue by Young's modulus.The hardness of the tissue is visualized in the form of color coding to distinguish the benign and malignant tissue detected.SWE has higher sensitivity,accuracy and specificity compared with traditional color doppler,which is more objective than elastography,safer,cheaper and simpler than MRI.SWE has a good application prospect in the diagnosis,clinical staging and curative effect monitoring of cervical cancer.
3.Research progress in regional odontodysplasia
Minjian SHEN ; Manting WANG ; Wenxiang JIANG ; Zhifang WU ; Qianming CHEN
Chinese Journal of Stomatology 2024;59(5):512-516
Regional odontodysplasia (ROD) is a rare localized dental developmental anomaly. The typical clinical manifestations of ROD are abnormal tooth eruption, abnormal development of enamel and dentin. The radiographic characteristic is "ghost teeth". Its etiology still remains unknown. The care and treatment of a patient with ROD needs a multidisciplinary approach. And the treatment should be taken after the assessment of each individual case of ROD. This paper reviews the definition, etiology, epidemiological features, clinical manifestations, imaging features, dental microstructure and treatment strategies of ROD to provide reference for clinical diagnosis and treatment.