Objective To compare the clinical efficacy between transurethral plasma kinetic enucleation of prostate(TUPKEP)and transurethral resection of prostate(TURP)on benign prostatic hyperplasia(BPH).Methods The clinical data of patients with BPH were retrospectively analyzed.The clinical results of 72 cases of TURP and 60 cases of TUPKEP were selected.Results The operation time,the amount of bleeding of the TUPKEP group were (51.3 ±5.9)min,(131.7 ±9.2)mL,which were significantly better than those of the TURP group [(62.5 ± 7.4)min,(174.2 ±10.5)mL](t =9.48,24.48,all P <0.05).The amount of prostate resection in the TUPKEP group[(62.4 ±7.0)g]was significantly higher than that in the TURP group[(45.9 ±6.1 )g],the difference was statistically significant(t =14.47,P <0.05).The incidence rate of complication in the TUPKEP group was 1.7%(1 /60),which was significantly lower than that of the TURP group 12.5%(9 /72),the difference was statistically significant(χ2 =5.50,P <0.05).The postoperative hospitalization time,bladder irrigation time,catheter indwelling time of the TUPKEP group were (4.3 ±1.0)d,(1.2 ±0.5)d,(2.6 ±0.3)d,which were shorter than those of the TURP group [(6.2 ±0.9)d,(2.3 ±0.9)d,(4.8 ±0.2)d],the differences were statistically significant(t =11.48, 8.44,50.27,all P <0.05).The maximum urinary flow rate(Qmax),residual urine volume(RUV),prostate function (IPSS)and quality of life(QOL)were significantly improved in the two groups before and after operation,the differ-ences were statistically significant(TURP group:t =2.46,18.49,2.55,4.37;TUPKEP group:t =2.88,17.59,2.64, 3.94;all P <0.05).But there were no significant differences in Qmax,RUV,IPSS score and QOL score between the two groups after surgery(t =0.24,0.50,0.56,0.94,all P >0.05).Conclusion The clinical efficacy of TUPKEP in the treatment of BPH is positive,it can relieve the symptoms of patients with difficulty in urination,improve the quality of life of patients,and the incidence of postoperative complications is low,it is worthy of clinical application.