The mandibular metastatic spread of carcinoma from the thyroid gland is exceedingly rare. Follicular thyroid carcinoma is the second most common type of thyroid carcinoma，accounting for approximately 10% to 15% of all thyroid cancers. The prognosis of FTC is relatively satisfactory. Due to its rich blood transport, it is easy to metastasize hematological, with the main sites of metastasis are bone and lung. However，mandibular metastasis of thyroid follicular carcinoma is rare. We report a case of thyroid follicular carcinoma that metastasized to the ascending ramus of the mandible 21 years after surgery.The operation was successfully completed, and there was no recurrence during postoperative follow-up. Due to the absence of obvious clinical symptoms in the patient, the diagnosis and treatment were challenging. We have provided detailed radiographic and pathological images to facilitate understanding and discussion of the disease.
Humans ; Adenocarcinoma, Follicular/pathology* ; Thyroid Neoplasms/surgery* ; Prognosis ; Mandible

Defects were created in the mandible of a rabbit model whereby the right side was implanted with hydroxyapatite (HA) while the left side was left empty to act as control. Both the implant and control sites were evaluated clinically and histologically at 4,12,20,22 weeks. Decalcified sections were studied under confocal laser scanning microscope. No reactive cells were evident microscopically in all sections. There was bone ingrowth as early as 4 weeks when viewed by the topographic method. Enhancement of osteoconduction was evident by the presence of abundant capillaries, perivascular tissue and osteoprogenitor cells of the host. At 22 weeks, the implanted defect showed mature bone formation filling almost the whole field. This study demonstrated that the dense HA exhibits excellent biocompatibility as noted by the complete absence of reactive cells. It also promotes osteoconduction.
*Bone Substitutes ; *Hydroxyapatites ; Mandible/pathology ; Mandible/*surgery ; *Materials Testing ; Osseointegration/physiology

Pus overflow from patent's fistula belew the left face near mandibular angle 2 years agowith a little pain. Symptoms relieved after oral antibiotics. This symptom frequently occurred in the past six months. Postoperative facial paralysis occurred after surgery, and recovered after treatment. It was diagnosed as the postoperative facial paralysis after first branchial fistula surgery.
Branchial Region ; pathology ; surgery ; Face ; Facial Paralysis ; etiology ; Fistula ; pathology ; surgery ; Humans ; Mandible ; Pain

Multilobular tumor of bone detected in a 2.5-year-old male Pekingese dog is reported. Grossly, the neoplasm consisted of multiple, variably sized, gritty, grayish-white to yellow nodules separated by thick collagenous septa. Histologically, these nodules contained multiple lobules of irregularly shaped and sized islands of well-differentiated osteoid and cartilage, separated by anastomosing fibrovascular septa. Chondrocytes and osteocytes were observed in the lacunae and in more osseous islands in the lobule, respectively. These lobules were surrounded by mesenchymal spindle cells. Mitotic figures were not evident. The neoplastic pattern was consistent with that of a multilobular bone tumor. Diagnosis was based on gross and light microscopic findings. The cause of this neoplasm was not determined.
Animals ; Bone Neoplasms/pathology/surgery/*veterinary ; Dog Diseases/*pathology/surgery ; Dogs ; Histocytochemistry/veterinary ; Male ; Mandible/*pathology/surgery ; Osteosarcoma/pathology/surgery/*veterinary

OBJECTIVETo investigate the clinical applicability and outcomes of the combined radical operation without breaking the lower lip and mandible with one-stage reconstruction using free anterolateral thigh flap for tongue and lingual root carcinoma.

METHODSThe operation with or without breaking lower lip and mandible was performed respectively in 245 patients (experimental group) and 120 patients (control group).

RESULTSRemoval of tumor and neck dissection were conducted successfully in all patients of two groups with no serious postoperative complication. With the follows-up of 6 to 36 months, in the patients of experimental group there was no recurrence for primary sites but 3 cases with neck lymphnode recurrence, the functions of chewing, swallowing and speaking were good, there was no damage to appearance, and no osteoradionecrosis occurred in the lymphnode positive cases after radiotherapy; in the patients of experimental group there was no recurrence for primary sites but 4 cases with neck lymphnode recurrence, the functions of chewing, swallowing and speaking were good, but there was apparent scar in neck and face, and osteoradionecrosis occurred in 11 of lymphnode positive cases.

CONCLUSIONSThe combined radical operation without breaking the lower lip and mandible with one-stage reconstruction using free anterolateral thigh flap is feasible for tongue and lingual root carcinoma (T2-T3), which reduces the risk for osteoradionecrosis in lymphnode positive cases after radiotherapy and keeps good appearance for patients.

Carcinoma ; surgery ; Free Tissue Flaps ; Humans ; Lingual Nerve ; pathology ; surgery ; Lip ; surgery ; Mandible ; surgery ; Neck Dissection ; Osteoradionecrosis ; Postoperative Complications ; Thigh ; Tongue ; surgery ; Tongue Neoplasms ; pathology ; surgery

OBJECTIVETo investigate the compensation of the upper and lower incisors in skeletal Class III patients treated with orthodontic-surgical approach.

METHODSThe samples consisted of 54 skeletal Class III patients treated with orthodontic-surgical approach from November 2011 to January 2015. Lateral cephalograms were taken before treatment. The differences between the samples and the norms from Peking University normal occlusion sample library were assessed using independent-sample t test. Correlation analyses were performed to find associations between skeletal and dental parameters. According to skeletal anteroposterior discrepancy/vertical type (ANB/SN-MP), the samples were allocated into group A (ANB < -4°, SN-MP ≤ 37.7°, n = 11), group B (ANB ≥ -4°, SN-MP ≤ 37.7°, n = 16), group C (ANB < -4°, SN-MP > 37.7°, n = 14), and group D (ANB ≥ -4°, SN-MP > 37.7°, n = 13). After measurement of variables, one-way ANOVA with SNK multiple comparison test were performed.

RESULTSThe maxillary incisors were more proclined and the mandibular incisors more retroclined in skeletal Class III patients compared with norm values (P < 0.01). Both skeletal anteroposterior discrepancy and vertical type were correlated with the position of upper and lower incisors (P < 0.01). According to skeletal anteroposterior discrepancy/vertical type, no significant differences were found in the upper incisors' inclination among the four groups, while patients in group A and group D exhibited significant difference in lower incisor compensation.

CONCLUSIONSDifferent skeletal anteroposterior discrepancy/vertical type resulted in varied incisors' compensation. Therefore, decompensation should be treated differently.

Analysis of Variance ; Beijing ; Cephalometry ; Humans ; Incisor ; pathology ; Malocclusion, Angle Class III ; classification ; pathology ; surgery ; Mandible ; Maxilla ; Orthognathic Surgery

OBJECTIVETo accelerate distraction osteogenesis by utilizing guided bone regeneration technique, and to improve the automatic process of canine segmental mandibular reconstruction by elasticity distraction osteogenesis using shape memory metal alloy distractor.

METHODSAdult hybrid canines were used. Osteotomy was performed to remove a bone segment of 2.5-4.0 cm in one side of the mandible. Mandibular fixation devices and shape memory metal alloy distractor were secured according to the principles of bi-focal distraction technique. A piece of ePTFE membrane was sutured to cover the buccal side of bone defect and osteotomy gap of transport disc, where the periosteum was peeled for exposing mandible in operation. Then the incisions were totally closed. The canines were sacrificed 3 months later to harvest the mandibles for morphological observation and measurement of bone density and intensity.

RESULTSThe shape memory metal alloy distractor performed distraction osteogenesis automatically and reconstructed the mandibles with bone defect. A regenerated bone segment of 1.5-2.0 cm was formed in the compression region between transport disc and contralateral mandibular end. The new bone in both of distraction and compression regions had similar height and thickness with normal mandible. Moreover the new bone density and intensity were rather satisfied.

CONCLUSIONSMembrane guided bone regeneration can avoid bone synthesis commonly caused by cicatrization of soft tissue in the bone defect, and accelerate ossification and maturation of new generated bone.

Animals ; Bone Regeneration ; Dogs ; Guided Tissue Regeneration ; Mandible ; pathology ; surgery ; Nickel ; Osteogenesis, Distraction ; instrumentation ; methods ; Titanium

Bone Plates ; Bone Screws ; Fracture Fixation, Internal ; methods ; Humans ; Mandible ; pathology ; surgery ; Mandibular Fractures ; surgery ; Reconstructive Surgical Procedures ; methods

BACKGROUNDResection of tumors arising from the tongue base and the parapharyngeal space is difficult for exposure and manipulation because of their obscure location. The aim of this study was to evaluate the surgical approach of the pre-mental foramen mandibulotomy for resecting the tumors of tongue base and parapharyngeal space.

METHODSFifty-one patients with tumors of tongue base and parapharyngeal space were treated using the mandibulotomy approach on the pre-mental foramen. In the present study, this technique was described in detail. The patients were followed up for three months to six years with a mean of 26 months.

RESULTSThe tumors of tongue base and parapharyngeal space could be exposed clearly and be resected radically by surgical approach of pre-mental foramen mandibulotomy. The surgical complications were reduced.

CONCLUSIONSCompared to other surgical approaches, such as lateral mandibulotomy, midline mandibulotomy, the suprahyoid parapharyngeal approach, and paramedian mandibulotomy, we found that the pre-mental foramen mandibulotomy is the ideal choice for resecting the tumors of tongue base and parapharyngeal space.

Adolescent ; Adult ; Aged ; Child ; Child, Preschool ; Female ; Humans ; Male ; Mandible ; surgery ; Middle Aged ; Pharyngeal Neoplasms ; pathology ; surgery ; Tongue Neoplasms ; pathology ; surgery

An unusual odontogenic cyst, which was originally believed to be a clinical dentigerous cyst associated with an impacted mandibular third molar, was found histologically to demonstrate the characteristics of a glandular odontogenic cyst with para- and orthokeratinization. These histologic diversities were interpreted as a reflection of the pluripotentiality of the epithelial remnants of the mandibular third molars or dentigerous cyst epithelium. It is possible that it has the capacity to induce the formation of cysts in both squamous and glandular epithelium.
Tomography, X-Ray Computed ; Odontogenic Cysts/*pathology/radiography/surgery ; Mandibular Diseases/*pathology/radiography/surgery ; Mandible/radiography ; Humans ; Female ; Epithelium/pathology ; Aged