Forty-three patients with papulo-pustular rosacea with Demodex(D.) folliculorum were treated for 8 weeks on a random basis either with tetracycline 250 mg three times daily or with metronidazole 250 mg three times daily. Both drugs produced an improvement which was greater after 8 weeks than after 4 weeks, but there was no significant difference between them. The number of D. follilculorum after treatment with tetracycline was slightly decreased, but the number of D. folliculorum after treatment with metronidazole was more decreased than the tetracycline group. Metronidazole appears to be a effective drug for the treatment of rosacea with D. folliculorum.
Humans ; Metronidazole* ; Rosacea* ; Tetracycline*

The important prerequisite for treatrnent of onychomycosis is the removal of as rnuch fungus-infected nail material as possible. Nincty-five patients with anychomycosis were treated with using urea preparations under occlusive dressings. The urea preparations were quite successful in maceraing the nail plate from the nail bed, allowing the easy removaI of diseased nails in all cases except one. The urea preparations removed only abnormal nail. Completely normal nail was unaffected. After nail avulsion, 95 patients were treated for 6 months with combination clotrimazole and ketoconazcile(group A), or with clotrimazole only(group B). Of the 38 patients in group A who complcted the treatment, 25(65.8%) were cured 6 months later by clinical and mycological criteria, compared to 20(47.6%) of 42 patieries in group B.
Clotrimazole ; Humans ; Ketoconazole ; Nails, Malformed ; Occlusive Dressings ; Onychomycosis* ; Urea

Lichen planus is rare in Korea and localized lichen planus on the lip without other skin lesions is even rarer. A 77-year-old man has oozing and crusting patches und somewhat ulceration surrounded by whitish reticular elements on violaceous base on both lips with burning sensation and pain. A 63-year-old man has well demarcated violaceous white reticular patches on the lower lip, buccal mucosa, glans penis and coronal sulcus. Clinical and histopathological studies of two cases showed typical features of lichen planus. They were treated with systemic and topical corticosteroids and showed much improvement.
Adrenal Cortex Hormones ; Aged ; Burns ; Humans ; Korea ; Lichen Planus* ; Lichens* ; Lip* ; Male ; Middle Aged ; Mouth Mucosa ; Penis ; Sensation ; Skin ; Ulcer

BACKGROUND: Since the exact pathogenesis of sepsis-induced ARDS has not been elucidated, the mechanisms of enhanced neutrophilic respiratory burst were probed in endotoxin primed neutrophils associated with the roles of phospholipase A2 (PLA2), platelet activating factor (PAF) and apoptosis. METHODS: In isolated fresh human neutrophils, effects of the inhibition of PLA2 and PAF on the apoptosis were examined by the method of Annexin-FITC/dual PI flow cytometry. The roles of PLA2 and PAF on the neutrophilic respiratory burst were also examined by measuring oxidant generation in cytochrome-c reduction assay. Activities of the PLA2 and lysoPAF acetyltransferase (lysoPAF AT) of the neutrophils were determined to understand the effect of endotoxin on these enzymatic activities which may be related to the neutrophilic respiratory burst and apoptosis. In addition, the role roles of PLA2 and PAF in neutrophilic adhesion to bovine endothelial cells were examined in vitro by neutrophil adhesion assay. To investigate the effect of oxidants on pulmonary surfactant, cytochemical ultrastructural microscopy was performed. To inhibit PLA2 and PAF, non-specific PLA2 inhibitor mepacrine (100 nM) and WEB 2086 (100 nM) or ketotifen fumarate (10 kg/ml) were used respectively in all in vitro experimental sets. WEB 2086 is PAF receptor antagonist, and ketotifen fumarate is a lyso PAF AT inhibitor. RESULTS: The mapacrine treatment, provided after the endotoxin (ETX) treatment, resulted in increased apoptosis of neutrophils (p<0.001) while treatments of WEB 2086 and ketotifen did not. The inhibition of PLA2 and PAF decreased (p<0.001) production of oxidants from PMA-stimulated neutrophils. While endotoxin increased the PLA2 activity of neutrophils (p<0.01), mepacrine supressed (p<0.001) the activity, provided after treatment of ETX. The lyso PAF actyltransferase activity (lyso PAF AT) increased(p<0.01) after treatment of ETX. In contrast, mepacrine, WEB 2086 and ketotifen showed a tendency of decreasing the activity after treatment of ETX. The Treatment of ETX increased (p<0.001) neutrophil adhesion to endothelial cells, which was reversed by inhibition of PLA2 and PAF (p<0.001). The binding of oxidants to pulmonary surfactant was identified histologically. CONCLUSIONS: The enhanced neutrophilic respiratory burst by ETX plays a pivotal role in the pathogenesis of ARDS in term of oxidayive oxidative stress. Increased production of oxidants form neutrophils is mediated by the activations of PLA2 and lyso PAF AT.
Apoptosis* ; Endothelial Cells ; Flow Cytometry ; Humans ; Ketotifen ; Microscopy ; Neutrophils* ; Oxidants ; Oxidative Stress ; Phospholipases A2 ; Platelet Activating Factor ; Pulmonary Surfactants ; Quinacrine ; Respiratory Burst*

Ischemic stroke is a serious neurological complication of infective endocarditis. Intravenous tissue plasminogen activator (t-PA), which has only been approved for treatment of hyperacute stroke, has been excluded as an ischemic stroke treatment due to infective endocarditis according to current expert consensus guidelines. Here, we describe a case of a hyperacute stroke patient treated with intravenous t-PA, who was later diagnosed with infective endocarditis.

Two cases report on osteogenesis imperfecta tarda and review of literature has been made. The rare genetic disorder, osteogenesis imperfecta tarda is familiar to most orthopedic surgeons because of management of fracture and skeletal deformities, espicially bowing of long bone. Its clinical manifestations are known as bony fragility, blue sclera and deafness less frequently ligamentous laxity but its etiological factor is obscure; The basic defect is thought to involvement some abnormality of collagen. Recently the bony weakness caused by increased bony turnover rate. One case of osteogenesis imberrfecta tarda in 8 year old male was belonged to tarda type 1. (Falvo-classification), who could not walk due to marked anterolateral bowing of right tibia and the another to tarda type II. in 13 year old male with fresh fracture of right femoral shaft. The former was performed corrective multible osteotomy, realignment and intramedullary rod fixation for correction of bowing deformity of right tibia, and the later was managed the fracture of right femoral shaft with Russels traction and hip spica cast. The result of reported therapeutic mesure was good.
Collagen ; Congenital Abnormalities ; Deafness ; Fibrinogen ; Hip ; Humans ; Ligaments ; Male ; Orthopedics ; Osteogenesis Imperfecta ; Osteogenesis ; Osteotomy ; Sclera ; Surgeons ; Tibia ; Traction

The corrected transposition of the great arteries is an usual congenital cardiac malformation, which consisitsof transposition of great arteries and ventricular inversion, and which is caused by abnormal developement ofconotruncus and ventricular looping. High frequency of associated cardiac malformations makes it difficult to getaccurate morphologic diagnosis. A total of 18 cases of corrected transposition of the great arteries is presented,in which cardiac catheterization and angiocardiography were done at the Department of Radiology, Seoul NationalUniversity Hospital between Sep. 1976 and June 1981. The clinical, radiogrpahic ,and operative findings with theemphasis on the angiocardiographic findings were analized. The resuls are as follows; 1. Among 18 cases, 13 caseshave normal cardiac position, 2 cases have dextrocardia with situs solitus, 2 cases have dextrocardia with situsinversus and 1 case has levocardia with situs inversus. 2. Segmental sets are {S.L.L.} in 15 cases, and {I.D.D} in3 cases and there is no exception to loop rule. 3. Side by side interrelationships of both ventricles and bothsemilunar valves are noticed in 10 and 12 cases respectively. 4. Subaortic type conus is noted in all 18 cases. 5.Associated cardiac malformations are VSD in 14 cases, PS in 11, PDA in 3, PFO in 3, ASD in 2, right aortic arch in2, tricuspid insufficiency, mitral prolapse, persistent left SVC and persistent right SVC in 1 case respectively.6. For accurate diagnosis of corrected TGA, selective biventriculography using biplane cineradiography is anessential procedure.
Angiocardiography ; Aorta, Thoracic ; Arteries ; Cardiac Catheterization ; Cardiac Catheters ; Cineradiography ; Conus Snail ; Dextrocardia ; Diagnosis ; Levocardia ; Mitral Valve Insufficiency ; Prolapse ; Seoul ; Situs Inversus ; Transposition of Great Vessels

Since Thomas et al reported the first instance of successful removal of a broken intravascular guidewire without surgical intervention by using a bronchoscopic forceps in 1964, there have been a number of nonsurgical removal of intravascular or intracardiac foreign bodies using the bronchoscopic forceps, loop snare or basket stone catchers. We experienced a successful retrieval of accidentally broken subclavian puncture catheter from right atrium in 76 year old male patient with cerebral infarction admitted to this hospital on May, 1989. By percutaneous catheterization via right basilic vein, using a loop snare which is modified manually by guidewire for PTCA(USIC(R) Teflon coated PTCA Guide wire : ".014"), we removed successfully foreign body from right atrium. Therefore, we report a case of nonsurgical retrieval of foreign body from right atrium with the review of the literature.
Aged ; Catheterization ; Catheters ; Cerebral Infarction ; Foreign Bodies* ; Heart Atria ; Humans ; Male ; Ocimum basilicum ; Polytetrafluoroethylene ; Punctures ; SNARE Proteins ; Surgical Instruments ; Veins

Urinary calculous disease is unusual in children. During the last 7.5 years period, author has experienced and treated 18 children suffering from urinary calculus from January, l978 to July, l985 at the Department of Urology, Chonbuk National University Hospital. The results are summarized as follows; 1. The incidence of the pediatric urolithiasis (18 cases) was 2.7% of 666 urolithiasis patients andO.6 % of total 2930 in-patients. 2. The age of the patients ranged from 12 months to 15 years old, with the highest incidence in 6-10 in age (60%) and male to female ratio 3.5: 1. 3. The locational distributions of urinary calculi were 15.8% in the kidney, 57.9% in the ureter 5.3 %, in the bladder, 21% in the urethra and 26.3% in lower urinary tract calculi. 4. The etiologies of urolithiasis were 77.7% in idiopathic, 5.5% in congenital and 16.8% in recurrent infection. 5. The clinical symptoms of urinary calculi were 25.8% in painful urination, 22.5% in flank pain, 6.5% in hematuria, 9.7% in frequency and 9.7% abdominal pain ete. 6. The size of stone was below 1.0cm in length 7 cases (70%), above 1.0cm in length 3 cases (30%). 7 The weight of urinary calculi was below of 0.4gm 6 cases (60%) and above of 1.0 gm 3 cases (30%). 8. Treatment consisted of Nephrolithotomy in l patient (5.3%), Pyelolithotomy in 6 patients (3l.6%), Ureterolithotomy in 2 patients (10.5%). Vesicolithotomy in 5 patients (=6.3%), and Spontaneorts passage in 5 patients (26.3%). 9. The results of chemical analysis and Infrared sphectroscopy of 10 urinary calculi are almost identical anti single calculi were 40%, mixed calculi were 60 %, calcium oxalate in 30% (3 cases), calcium oxalate and calcium phosphate in 30% (3 cases), calcium oxalate and calcium carbonate in 20%, (2 cases) calcium oxalate and uric acid in 10% (1 case), uric acid in 10% (1 case). The major component of urinary calculi was calcium phosphate oxalate.
Abdominal Pain ; Adolescent ; Calcium ; Calcium Carbonate ; Calcium Oxalate ; Calculi ; Child* ; Female ; Flank Pain ; Hematuria ; Humans ; Incidence ; Jeollabuk-do ; Kidney ; Male ; Spectrum Analysis* ; Ureter ; Urethra ; Uric Acid ; Urinary Bladder ; Urinary Calculi ; Urinary Tract ; Urination ; Urolithiasis* ; Urology

BACKGROUND: Almost all STD(sexually tranamitted diseases) have been increasing worldwide since the 1960s. In Korea, the occurrence of STD from recent trends of sexual openness and development in the pleasure-seeking industry is becoming a social issue. However, epidemiological studies and reports concerning the incidence of STD are lacking in Korea, especially in the sexually aetive young age group. OBJECTIVE: We evaluated the incidence of YTD and sexual behavior of recruits in a Korean arrny training center to contribute to the management of STD in Korea. METHODS: We studied 1304 recruits in a Korean army training center by questionnaire, physical examination and laboratory data. The subjects were divided into 3 groups: group 1(1072 persons), those who visited the hospital for evaluation of STD; group 2(641 persons), a control group for coitus rate; and group 3(1304 persons; group 1 plus 232 persons out of group 2), those who had coital experiences. RESULTS: 1. The incidence of STD in group 1 was 65.7%(704/1072) and that of the total number of recruits was 0.43%(704/164,134). 2. Among the 704 cases of STD, the most frequently observed STD was non-gonococcal urethritis, 292 cases(41.5%) and the second was gonorrhea, 236 cases(33.5%). The others were, 68 cases(9.7%) of pediculosis pubis, 41 cases(5.8%) of condyloma acuminatum, 29 cases(4.1%) of syphilis, 20 cases(2.8%) of combined STD, 14 cases(2%) of herpes progenitalis, 2 cases(0.28%) of molluscum cohtagiosum and 2 cases(0.28%) of chancroid. 3. The coitus rate in group 2 was 36.2%(232/641). 4. The incidence of previous STD in group 3 was 20.9%(273/1304). 5. The mn;t common form of STD which the patients experienced previously was urethritis(82.8%) and the others were pediculosis pubis(7.3%), syphilis(3.3%), condylcena acuminahun and herpes progenitalis. 6. The group with more sexual partners tended to have a lower educational level. 7. The experience rate of drug abuse was higher in the group with more sexual partners. 8. The experience rate of oral and anal sex was higher in the group with experiences of clrug abuse than in the ather one. CONCLUSION: In this study, urethritis was the most common form of STD(75% of all STD) and non-gonococcal urethritis showed a greater incidence than gonorrhea. The incidence of STD is thought to be closely related to the factors associated with social or behavioral science, such as the number of sexual partners, grade of education, drug abuse, experience of oral and anal sex. To accomplish more effective management of STD, therefore, the improvement of current social problems involving sexual openness, the pleasure-seeking industry and drug abuse should be achieved.
Behavioral Sciences ; Chancroid ; Coitus ; Education ; Epidemiologic Studies ; Gonorrhea ; Humans ; Incidence ; Korea ; Lice Infestations ; Physical Examination ; Sexual Behavior* ; Sexual Partners ; Sexually Transmitted Diseases* ; Social Problems ; Substance-Related Disorders ; Syphilis ; Urethritis ; Surveys and Questionnaires