No abstract available.
Magnetic Resonance Imaging* ; Tuberculosis, Spinal*

No abstract available.
Humans ; Infant* ; Parturition*

No abstract available.
Child* ; Humans

To evaluate the reliability of MR imaging in tissue characterization and depiction of tumor boundaries, we performed MR-pathologic correlation using parosteally implanted VX-2 carcinoma in 17 rabbit thighs. T1-weighted, T2-weighted and Gd-DTPA enhanced T1-weighted axial images were obtained 10-30 days after tumor implantation. After the animals were killed, frozen and sectioned along the MR imaging planes, and histopathologic examinaton were done. For accurate MR-pathologic correlation, rabbits were fixed on the cardboard plate to minimize position change during the procedures. Tumor boundaries depicted on MR images were larger than those depicted on the specimen. Small tumors were surrounded by capsule-like loose connective tissue. Loose connective tissue became compact with tumor growth. This connective tissue showed high signal intensity on both T2-weighted and Gd-DTPA enhanced T1-weighted images. Muscle atrophy with fatty tissue accumulation around the tumor also contributed to the high signal intensity on MR images. Peritumoral edema and inflammatory reaction were not remarkable. Six of 8 cases with bone marrow fibrosis were detected on MR images. We concluded that peritumoral loose connective tissue and muscle atrophy exaggerated the size of experimentally induced malignant musculoskeletal tumors on MR images.
Adipose Tissue ; Animals ; Connective Tissue ; Edema ; Gadolinium DTPA ; Magnetic Resonance Imaging ; Muscular Atrophy ; Primary Myelofibrosis ; Rabbits ; Thigh

No abstract available.
Vascular System Injuries

Mucocele of concha bullosa is rare and can be misdiagnosed as an intranasal tumor mass. We report a case ofmucopyocele of the concha bullosa.
Mucocele*

PURPOSE: The purpose of this study was to determine the effect of preserving muscle length or excursion on the progression of myostatic contracture after tendon injury in a rabbit soleus tenotomy model. MATERIALS AND METHODS: Forty rabbits underwent tenotomy of the soleus muscles bilaterally and the tendons were managed according to the five experimental groups (N=40). Group A was a tendon-lengthening group maintaining a half of the excursion. In group B, maximal muscle length was maintained and in group C, resting muscle length was maintained. In group D, the tendon was allowed to undergo myostatic contracture and in group E, the tendon was partially transected and repaired. Four and eight weeks postoperatively, soleus muscles were harvested from each hindlimb and histomorphometric evaluations were performed to measure the connective tissue and fiber cross-sectional areas. Electrophysiologic studies were carried out to measure the compound muscle action potential to assess the number of functioning muscle fibers. RESULTS: The results showed that maximal muscle length preservation (Group B) was the most protective in preventing muscle contracture within 4 weeks of tenotomy, but this protective effect was gradually offset by prolonged immobilization, and 8 weeks after tenotomy, maintenance of excursion (Group A) was the most protective. CONCLUSION: These observations can be useful in the intraoperative evaluation of myostatic contracture in neglected tendon ruptures, and be applied to the management of acute tendon injuries to prevent myostatic contracture when immediate anatomical reconstruction cannot be performed.
Action Potentials ; Animals ; Connective Tissue ; Contracture* ; Hindlimb ; Immobilization ; Muscles* ; Rabbits ; Rupture ; Tendon Injuries ; Tendons ; Tenotomy

An exceedingly rare case of perforated early gastric cancer is reported. A 68-year-old man developed peritonitis due to perforation of early gastric cancer. An emergency radical operation was performed and was followed by an uneventful recovery. Histologic examination of the surgical specimen showed type III early gastric cancer composed of a signet ring cell carcinoma. Five years after surgery, the patients was alive with no evidence of tumor recurrence. The rarity of this complication in early gastric cancer is discussed, and a review of the literature is presented.
Aged ; Carcinoma, Signet Ring Cell ; Emergencies ; Humans ; Peritonitis ; Recurrence ; Stomach Neoplasms*

Recently it was shown that single nucleotide polymorphisms (SNPs) can explain individual variation because of the small changes of the gene expression level and that the 50% decreased expression of an allele might even lead to predisposition to cancer. In this study, we found that a decreased expression of an allele might cause predisposition to genetic disease. Dopa responsive dystonia (DRD) is a dominant disease caused by mutations in GCH1 gene. The sequence analysis of the GCH1 in a patient with typical DRD symptoms revealed two novel missense mutations instead of a single dominant mutation. Family members with either of the mutations did not have any symptoms of DRD. The expression level of a R198W mutant allele decreased to about 50%, suggesting that modestly decreased expression caused by an SNP should lead to predisposition of a genetic disease in susceptible individuals.
Child ; Clubfoot/genetics ; Dopamine/deficiency ; Dystonic Disorders/drug therapy/enzymology/*genetics/physiopathology ; GTP Cyclohydrolase/*genetics/metabolism ; Genes, Recessive ; *Genetic Predisposition to Disease ; Humans ; Levodopa/administration & dosage ; Male ; Mutation, Missense ; Pedigree ; Polymorphism, Genetic

PURPOSE: It was studied that the relationship between radiation dose, dose rate and the frequency of chromosomal aberrations in peripheral lymphocytes. METHODS AND MATERIALS: Peripheral lymphocytes were irradiated in vitro with 6 MeV X-ray at dose ranges from 50 cGy to 800 cGy. The variations of the frequency of chromosomal aberrations were observed according to different radiation dose rate from 20 cGy/min to 400 cGy/min at constant total dose of 400 cGy which it was considered as factor to correct biological radiation dose measurement. RESULTS: The yields of lymphocytes with chromosomal aberrations (dicentric chromosome, ring chromosome, acentric fragment pairs) are 0% at 50 cGy, 9% at 100 cGy, 20% at 200 cGy, 27% at 300 cGy, 55% at 400 cGy, 88% at 600 cGy, and 100% at 800 cGy. The value of Ydr is 0.000 at 50 cGy, 0.093 at 100 cGy, 0.200 at 200 cGy, 0.364 at 300 cGy, 0.612 at 400 cGy, 2.040 at 600 cGy, and 2.846 at 800 cGy. The relationship between radiation (D) and the frequency of dicentric chromosomes and ring chromosomes (Ydr) can be expressed as Ydr=0.188x10-2/GyxD+0.422x10-4/Gy2xD2. The value of Qdr is 0.000 at 50 cGy, 1.000 at 100 cGy, 1.000 at 200 cGy, 1.333 at 300 cGy, 1.118 at 400 cGy, 2.318 at 600 cGy, and 2.846 at 800 cGy. When 400 cGy is irradiated with different dose rate each of 20, 40, 60, 80, 100, 160, 240, 320, and 400 cGy/min, Ydr is each of 0.982, 0.837, 0.860, 0.732, 0.763, 0.966, 0.909, 1.006, and 0.806, and Qdr is each of 1.839, 1.565, 1.654, 1.333, 1.381, 1.750, 1.6000, 1.710, and 1.318. CONCLUSION: There are not the significant variations of Ydr and Qdr values according to different dose rate. And so radiation damage is influenced by total exposed radiation doses and is influenced least of all by different dose rate when it is acute single exposure.
Chromosome Aberrations* ; Lymphocytes* ; Ring Chromosomes