An experimental study on the effect of the induced dislocation of the femoral head on the femoral anteversion was made in the hips of 55 rabbits, three to four weeks old. The results were as follows; l. In 49 of the 55 operated rabbits, a relative increase of anteversion was observed on the dislocated side, as compared with the nonoperated femur, the differences ranging from 3 to 55 degrees with an average of 20.0 degrees. 2. The anteversion angle of dislocated hip showed steady and gradual increase with the increase of age. 3. The anteversion increase was detected very early after operation; 3 of the 4 rabbits, belonging 4 to 7 days group after operation showed the anteversion increase. 4. The collapse of proximal femoral epiphysis was observed in 42 of the total 55 hips. The incidence of the collapse was higher in postoperative 4 weeks and more groups. 5. The color change, pale discoloration, of the articular cartilage was observed in 32 of the total 55 hips. The icnidence of pale discoloration was higher in the groups within 8 weeks after operation.
Cartilage, Articular ; Congenital Abnormalities ; Dislocations ; Epiphyses ; Femur ; Head ; Hip ; Incidence ; Rabbits

Authors report the preliminary result of 86 consecutive femoral head replacements with ceramic head performed at Chonnam University Hospital(73 hips) and Kwangju Christian Hospital(13 hips) during the period of 2 years and 6 months between January 1985 and June 1987. The results were as follows ; l. Eighty-three patients were comprised of 41 men(44 hips) and 42 women(42 hips). 2. Their average age at operation was 62.8 years, the oldest being 86 and the youngest being 24 years and 57 patients(68.7%) of them were over 60 years of age. 3. The causative diseases of the femoral head were hip fracture and its related conditions in 74 hips, and idiopathic avascular necrosis in 12 hips. 4. Associated general diseases, a total of 69 in number, could be diagnosed in 54 patients of them. These included hypertension(18 patients), cardiovascular disease(10 patients), and diabetes mellitus(8 patients). 5. The average diameters of the ceramic head were 49.8 mm in men and 45.1 mm in women. 6. The types of femoral stem were cemented stem(Xenophor 900 stem) in 45 hips and noncemented stem(Autophor 900S stem) in 41 hips. 7. The early postoperative complications, a total of 9 in number, were encountered and these included death in hospital(3 patients), trochanteric fracture(2 patients), pneumonia (1 patient), and others(3 patients). 8. The late postoperative complications, a total of 9 in number, were encountered and these included acetabular erosion(4 hips) and heterotopic ossification(5 hips). 9. Forty-nine hips could be followed more than 1 year with average follow-up of 19.9 months. The hip function of these 49 hips were excellent in 13 hips, good in 24 hips, fair in 8 hips, poor in 3 hips and bad in 1 hip. 10. In conclusion, it can be stated that the femoral head replacement with ceramic head prosthesis is very promising in reducing the incidence of acetabular erosion and maintaining the regained hip function.
Acetabulum ; Ceramics ; Female ; Femur ; Follow-Up Studies ; Gwangju ; Head ; Hemiarthroplasty ; Hip ; Humans ; Incidence ; Jeollanam-do ; Male ; Necrosis ; Pneumonia ; Postoperative Complications ; Prostheses and Implants

OBJECTIVES: It is well established that primary insomnia affects the activity of autonomic nervous system. We tried to know how the activity of autonomic nervous system during night sleep changes by analyzing correlation between heart rate variability (HRV) index and the variables related with sleep structure in primary insomnia. METHODS: Thirty three subjects (mean age:36.2+/-14.2 years, male:female=15:18) who were diagnosed with primary insomnia were selected for the study. Nocturnal polysomnography (NPSG) was carried out on each subject and correlation was analyzed between high frequency/low frequency ratio (LF/HF ratio), one of HRV indices and the variables related with sleep structure which were calculated from NPSG. RESULTS: When age and sex were controlled, LF/HF ratio showed negative correlations with slow wave sleep and stage 2 sleep, respectively (r(p)=-0.43, p=0.01;r(p)=-0.37, p=0.04). On the other hands LF/HF ratio showed a positive correlation with arousal index (r(p)=0.65, p<0.001). The activity of autonomic nervous system responded differentially depending on the change of sleep structure in primary insomnia. Especially the increase of arousal index and the decrease of slow wave sleep and stage 2 sleep which are the components of non-REM sleep provoked hyperactivity of sympathetic nervous system. CONCLUSION: This study suggests that the typical change of sleep structure in primary insomnia can negatively impact on cardiovascular system.
Arousal ; Autonomic Nervous System ; Cardiovascular System ; Hand ; Heart ; Heart Rate ; Polysomnography ; Sleep Initiation and Maintenance Disorders

PURPOSE: To evaluate the incidence of deep vein thrombosis (DVT) and the correlation between DVT and its risk factors after total hip replacement (THR) . MATERIALS AND METHODS: Sixty patients (64 cases) who underwent THR from May, 1996 to June, 1998 were evaluated for the incidence of DVT and its correlation with well-known risk factors such as age, body mass index (BMI) , sex, coagulation assay (platelet, prothrombin time (PT) , activated partial thromboplastin time (aPTT) , Anti-thrombin III, fibrinogen) , operating time and use of bone cement. All patients wore elastic compression stocking and were encouraged to exercise early. Venography was obtained between 7th and 14th day postoperatively. RESULT: DVT was detected in 5 cases (7.8%) . All thrombi were found in the calf vein. All patients did not show symptoms of DVT and did not necessitate treatment. Unlike other reports, we did not identify the correlation between DVT and risk factors. CONCLUSION: In this study, deep vein thrombosis did not reveal significant clinical problems because the incidence of DVT was lower than that of Western reports. Also thrombi were smaller and were mainly located in the calf vein. However more studies should be done, since there is a possibility of increase in DVT incidence due to the change in life style of the Korean population.
Arthroplasty, Replacement, Hip* ; Body Mass Index ; Humans ; Incidence* ; Life Style ; Partial Thromboplastin Time ; Phlebography ; Prothrombin Time ; Risk Factors* ; Stockings, Compression ; Veins ; Venous Thrombosis*

PURPOSE: To review the clinical and radiological results after wire fixation for acetabular fracture, and determine its indications and advantages. MATERIALS AND METHODS: A clinical analysis was performed on 12 cases of displaced unstable acetabular fracture which had been fixed by wiring. They were evaluated after a mean follow up of 1.7 years. The fixation was done only by wires in 3 cases, wires with plates and screws in 7 cases and wires with screws in 2 cases. RESULTS: Satisfactory results were achieved in 11 cases (91.7%) on clinical grade and 10 cases (83.4%) on radiographic grade according to Epstein criteria. Deep wound infection developed in 1 case and posttraumatic arthritis in 1 case. CONCLUSIONS: The reduction and fixation could be easily performed with the use of wires in some specific cases. Wire could fix fractures with or without combined use of plates or screws. The fracture types that are thought to be ideal indication for wire fixation are (1) a fracture line that extends above the greater sciatic notch, (2) a transverse acetabular fracture that has an obliquity from anteroinferior to posterosuperior and (3) isolated anterior column fracture.
Acetabulum* ; Arthritis ; Follow-Up Studies ; Wound Infection

The purpose of study was to determine the incidence of hip fracture in 2001, to compare this with that of 1991, and to identify possible causes of change. Patients aged 50 yr or more living in Gwangju City and Chonnam Province, Korea, and who sustained a fracture of the hip during 2001 were investigated. Only patients who were admitted to hospitals for primary treatment of the first hip fracture were selected. There were 1,152 patients. A comparison of fracture incidences for 1991 and 2001 showed considerable increase during the 10-yr period. The total annual number of hip fractures rose from 247 in 1991 to 1,152 in 2001 and the fracture incidence also increased remarkably from 3.3 persons per 10,000 population in 1991 to 13.3 in 2001, representing a 4-fold increase over 10-yr. The reasons for this rising trend of hip fracture were not fully explained. However, an increase in the elderly population, an increase in osteoporosis, and an increase in injurious falls could partly account for the observed increase.
Age Distribution ; Aged ; Aged, 80 and over ; Comparative Study ; Female ; Hip Fractures/*epidemiology ; Humans ; Incidence ; Korea/epidemiology ; Male ; Middle Aged ; Sex Distribution

BACKGROUND: LKB1(STK11) is a serine/threonine kinase that functions as a tumor growth suppressor. The functions of LKB1 in lung cancer are not completely understood. This study evaluated the relationship between LKB1 protein expression and the clinicopathological features in lung cancer tissues. METHODS: The expression of LKB1 was studied in paraffin-embedded tumor blocks, which were obtained from 77 patients who had undergone surgery at Wonkwang University Hospital. The expression of the LKB1 protein was considered positive if the staining intensity in the tumor tissue adjacent to the normal airway epithelium was >30%. RESULTS: The LKB1 expression was positive in 31 (40%) of samples. Loss of LKB1 expression was significantly associated with being male, smoking history, and squamous cell carcinoma. In the peripheral sites, the loss of LKB1 expression was strongly associated with a smoking history. A loss of LKB1 expression was more frequently associated with progression according to TNM staging, particularly more than T2, N progression. CONCLUSION: There was a significant relationship between the loss of the LKB1 protein and gender, smoking history, and histological type in primary lung cancer. Although LKB1 expression was not found to be a significant prognostic factor, further studies with a larger cohort of patient's lung cancer tissue samples will be needed to confirm this.
Carcinoma, Squamous Cell ; Cohort Studies ; Epithelium ; Humans ; Lung ; Lung Neoplasms ; Male ; Neoplasm Staging ; Phosphotransferases ; Smoke ; Smoking