2.Management of Opportunistic Infections after Organ Transplantation.
The Journal of the Korean Society for Transplantation 2015;29(1):9-15
Solid organ transplantation is a therapeutic option for end-stage organ diseases. However, complications including infection and graft rejection, which are related to immunosuppressive therapy, remain the major causes of morbidity and mortality following solid organ transplantation. The optimal approach to infection in solid organ transplant recipients is prevention; failing this, prompt and aggressive diagnosis and therapy are essential. In addition, the epidemiology of infections after solid organ transplantation has shifted as a result of changes in immunosuppressive strategies and improved survival. Immunosuppression must be linked with appropriate vaccinations, donor and recipient screening, patient education regarding infectious risks and lifestyle, monitoring, and antimicrobial prophylaxis.
Diagnosis
;
Epidemiology
;
Graft Rejection
;
Humans
;
Immunosuppression
;
Life Style
;
Mass Screening
;
Mortality
;
Opportunistic Infections*
;
Organ Transplantation*
;
Patient Education as Topic
;
Tissue Donors
;
Transplants*
;
Vaccination
3.(99m) Tc - MDP Bone Scintigraphy Findings Representing Osteoporosis.
Dae Gun NAM ; Tae Geon MOON ; Ji Hong KIM ; Seok Man SON ; In Ju KIM ; Yong Ki KIM
Korean Journal of Nuclear Medicine 2001;35(3):161-167
No abstract available.
Osteoporosis*
;
Radionuclide Imaging*
4.Outcome of Pallidal Deep Brain Stimulation in Meige Syndrome.
Ju Young GHANG ; Myung Ki LEE ; Sung Man JUN ; Chang Ghu GHANG
Journal of Korean Neurosurgical Society 2010;48(2):134-138
OBJECTIVE: Meige syndrome is the combination of blepharospasm and oromandibular dystonia. We assessed the surgical results of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with medically refractory Meige syndrome. METHODS: Eleven patients were retrospectively analyzed with follow-ups of more than 12 months. The mean follow-up period was 23.1 +/- 6.4 months. The mean age at time of surgery was 58.0 +/- 7.8 years. The mean duration of symptoms was 8.7 +/- 7.6 years. DBS electrodes were placed under local anesthesia using microelectrode recording and stimulation. After 2.4 +/- 1.3 days of trial tests, the stimulation device was implanted under general anesthesia. Patients were evaluated using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). RESULTS: BFMDRS total movement scores improved by 59.8%, 63.5%, 74.1%, 74.5%, and 85.5% during the immediate postoperative period of test stimulation, 3, 6, 12, and 24 months (n = 5) after surgery, respectively. The BFMDRS total movement scores were reduced gradually and the results reached statistical significance in the postoperative period (test period, p < 0.001; 3 months, p < 0.001; 6 months, p = 0.003; 12 months, p < 0.001; 24 months, p = 0.042). There was no statistical difference between 12 months and 24 months. BFM subscores improved by 63.3% for the eyes, 80.9% for the mouth, 68.4% for speech/swallowing, and 87.9% for the neck at 12 months after surgery. The adverse effects were insignificant. CONCLUSION: The bilateral GPi-DBS can be effective for the treatment of intractable Meige syndrome without significant side effects.
Anesthesia, General
;
Anesthesia, Local
;
Blepharospasm
;
Deep Brain Stimulation
;
Dystonia
;
Electrodes
;
Eye
;
Follow-Up Studies
;
Globus Pallidus
;
Humans
;
Meige Syndrome
;
Microelectrodes
;
Mouth
;
Neck
;
Postoperative Period
;
Retrospective Studies
5.Acute Arterial Occlusion Following Primary Total Knee Arthroplasty
Bong Ju PARK ; Hong Man CHO ; Ki Yong AN ; Hyun Ju LEE
The Journal of Korean Knee Society 2018;30(1):84-88
Acute arterial occlusion is a rare complication following total knee arthroplasty (TKA). This is a report of a case of acute femoral artery occlusion and its sequelae following TKA in a patient with a history of atrial fibrillation. Arterial circulation of the lower limb could not be restored by thrombectomy treatments, and above-knee amputation had to be carried out.
Amputation
;
Arteries
;
Arthroplasty
;
Arthroplasty, Replacement, Knee
;
Atrial Fibrillation
;
Femoral Artery
;
Humans
;
Knee
;
Lower Extremity
;
Thrombectomy
6.Gastric Perforation Associated with Vascular Invasive Mucormycosis in a Renal Transplant Recipient.
Tae Yon SUNG ; Yu Seun KIM ; Hyung Joon AHN ; Yoon Hee LEE ; Man Ki JU ; Woo Jin HYUNG
Journal of the Korean Surgical Society 2006;71(5):376-378
The clinicopathological manifestations of gastric mucormycosis range from colonization of ulcer disease to infiltration of tissue with or without vascular involvement. The prognosis of this disease is extremely poor when blood vessel invasion is observed. Herein, we report on a rare case of ischemic gastric perforation that was associated with vascular invasive mucormycosis in a renal recipients 7 years after transplantation.
Blood Vessels
;
Colon
;
Kidney Transplantation
;
Mucormycosis*
;
Prognosis
;
Transplantation*
;
Ulcer
7.Recurrent Urinary Tract Obstruction Due to Long-Coiled Transplant Ureter and Extrinsic Ureteric Compression.
Hye Youn KWON ; Man Ki JU ; Hyung Joon AHN ; Young Taik OH ; Yu Seun KIM
The Journal of the Korean Society for Transplantation 2006;20(2):265-268
Urinary tract complications, manifesting as leakage or obstruction, generally occur in 3.0~13% of renal recipients. Most complications occur at the ureterovesical anastomosis and are secondary to technical causes and ureteric ischemia. Ultrasound and computed tomographic images are described in a recipient who underwent oversea deceased donor renal transplantation and presented with recurrent ureteral obstruction and hydronephrosis secondary to combination of unusually located transplant kidney, long-coiled ureter, ureteric compression and ischemia of the transplant ureter.
Humans
;
Hydronephrosis
;
Ischemia
;
Kidney
;
Kidney Transplantation
;
Tissue Donors
;
Ultrasonography
;
Ureter*
;
Ureteral Obstruction
;
Urinary Tract*
8.A Clincal Follow-up Study of Asthma from Childhood to Adulthood.
Kyung Hwa PARK ; Hyun Hee LEE ; Man Young HAN ; Byung Ju JEONG ; Kyu Earn KIM ; Ki Young LEE
Pediatric Allergy and Respiratory Disease 1998;8(1):90-97
PURPOSE: Intermittent bronchial obstruction and increased airway responsiveness to inhaled nonspecific stimuli are main features of asthma. We retrospectively studied a group of children with asthma to investigate the contribution of childhood asthma characteristics and degree of bronchial responsiveness in combination with other variables in the prediction of adult level of pulmonary function & bronchial responsiveness. METHODS: We carried out the retrospective study on 65 adult patients who had been performed methacholine provocation test at Yonsei university children's allergic clinic from March 1994 to July 1997. These cases were diagnosed bronchial asthma on childhood. RESULTS: 1) In this study 65 patients were investigated, 45 subjects(69.3%)(A) were negative on methacholine provocation test, & 20 subjects(30.7%)(B) were positive. 2) Age of onset of asthma, A group was earlier than B group.(1.2 vs. 3.8 year) 3) There was significant relationship between mean PC20-methacholine and % predicted FEV. 4) There was no significant difference between A & B group in the number of allergen & duration included in the immunotherapy. CONCLUSIONS: We conclude that age of onset, degree of symptoms, % predicted FEV of childhood asthma are relevant to predict the outcome of the adult pulmonary function level, and the childhood degree of bronchial responsiveness are important for the prediction of adult degree of bronchial responsiveness among children with asthma.
Adult
;
Age of Onset
;
Asthma*
;
Child
;
Follow-Up Studies*
;
Humans
;
Immunotherapy
;
Methacholine Chloride
;
Retrospective Studies
9.Rifampicin Alleviates Atopic Dermatitis-Like Response in vivo and in vitro.
Seung Hyun KIM ; Ki Man LEE ; Geum Seon LEE ; Ju Won SEONG ; Tae Jin KANG
Biomolecules & Therapeutics 2017;25(6):634-640
Atopic dermatitis (AD) is a common inflammatory skin disorder mediated by inflammatory cells, such as macrophages and mast cells. Rifampicin is mainly used for the treatment of tuberculosis. Recently, it was reported that rifampicin has anti-inflammatory and immune-suppressive activities. In this study, we investigated the effect of rifampicin on atopic dermatitis in vivo and in vitro. AD was induced by treatment with 2, 4-dinitrochlorobenzene (DNCB) in NC/Nga mice. A subset of mice was then treated with rifampicin by oral administration. The severity score and scratching behavior were alleviated in the rifampicin-treated group. Serum immunoglobulin E (IgE) and interleukin-4 (IL-4) levels were also ameliorated in mice treated with rifampicin. We next examined whether rifampicin has anti-atopic activity via suppression of mast cell activation. Rifampicin suppressed the release of β-hexosaminidase and histamine from human mast cell (HMC)-1 cultures stimulated with compound 48/80. Treatment with rifampicin also inhibited secretion of inflammatory mediators, such tumor necrosis factor-α (TNF-α) and prostaglandin D₂ (PGD₂), in mast cells activated by compound 48/80. The mRNA expression of cyclooxygenase 2 (COX-2) was reduced in the cells treated with rifampicin in a concentration-dependent manner. These results suggest that rifampicin can be used to treat atopic dermatitis.
Administration, Oral
;
Animals
;
Cyclooxygenase 2
;
Dermatitis, Atopic
;
Histamine
;
Humans
;
Immunoglobulin E
;
Immunoglobulins
;
In Vitro Techniques*
;
Interleukin-4
;
Macrophages
;
Mast Cells
;
Mice
;
Necrosis
;
Rifampin*
;
RNA, Messenger
;
Skin
;
Tuberculosis
10.Rifampicin Alleviates Atopic Dermatitis-Like Response in vivo and in vitro.
Seung Hyun KIM ; Ki Man LEE ; Geum Seon LEE ; Ju Won SEONG ; Tae Jin KANG
Biomolecules & Therapeutics 2017;25(6):634-640
Atopic dermatitis (AD) is a common inflammatory skin disorder mediated by inflammatory cells, such as macrophages and mast cells. Rifampicin is mainly used for the treatment of tuberculosis. Recently, it was reported that rifampicin has anti-inflammatory and immune-suppressive activities. In this study, we investigated the effect of rifampicin on atopic dermatitis in vivo and in vitro. AD was induced by treatment with 2, 4-dinitrochlorobenzene (DNCB) in NC/Nga mice. A subset of mice was then treated with rifampicin by oral administration. The severity score and scratching behavior were alleviated in the rifampicin-treated group. Serum immunoglobulin E (IgE) and interleukin-4 (IL-4) levels were also ameliorated in mice treated with rifampicin. We next examined whether rifampicin has anti-atopic activity via suppression of mast cell activation. Rifampicin suppressed the release of β-hexosaminidase and histamine from human mast cell (HMC)-1 cultures stimulated with compound 48/80. Treatment with rifampicin also inhibited secretion of inflammatory mediators, such tumor necrosis factor-α (TNF-α) and prostaglandin D₂ (PGD₂), in mast cells activated by compound 48/80. The mRNA expression of cyclooxygenase 2 (COX-2) was reduced in the cells treated with rifampicin in a concentration-dependent manner. These results suggest that rifampicin can be used to treat atopic dermatitis.
Administration, Oral
;
Animals
;
Cyclooxygenase 2
;
Dermatitis, Atopic
;
Histamine
;
Humans
;
Immunoglobulin E
;
Immunoglobulins
;
In Vitro Techniques*
;
Interleukin-4
;
Macrophages
;
Mast Cells
;
Mice
;
Necrosis
;
Rifampin*
;
RNA, Messenger
;
Skin
;
Tuberculosis