Clonorchiasis for which no specific therapy is available has been recognized as one of the serious public health problems in terms of waste of human productivity in Korea today and an urgent consideration must be given to its prevention and control. For past several years, the author has been finding that the infection rate of liver fluke in fish from the Kum-Ho river which has long been recognized as the world's notorious prevalent area of the disease, has been decreasing gradually. Here the author formulated the hypothesis that the decreasing of infection rate might be influenced by the common use of pesticide in plants along the river. Basing this hypothesis, the effective use of pesticide may contribute to the control of the disease by cutting the life cycle of liver fluke. To test above hypothesis, molluscicidal effect on Parafossarulus manchouricus and cercariacidal effect of various pesticides in liver fluke have been determined and the following results were obtained. In molluscicidal effect, the most potent agent in low concentration was Bayer 73 which is 3 to 70 times stronger than other pesticides. When compared with NaPCP which has been widely used for the eradication of Onchomelania, Bayer 73 shows 5 to 10 times stronger effect. The order of pesticide in molluscicidal effect was: Bayer 73, Nicotin, NaPCP, Sevin, Parathion, Copper sulfate and Lindane. In cercariacidal effect, the most potent agent was Parathion which had 2 to 5 times stronger effect than Bayer 73 or NaPCP. The order of pesticide in the cercariacidal effect was: Parathion, Bayer73, NaPCP, Lindane, Nicotin,Sevin, and Copper sulfate. By applying the common used concentration of pesticides considering the toxicity to plants, Bayer 73 is most potent in molluscicidal effect and then Nicotin, NaPCP, Copper sulfate, Sevin, Parathion and Lindane in order. In cercariacidal effect, Parathion is the most potent and NaPCP, Bayer 73, Lindane, and Copper sulfate are followed. Considering with the toxicity to human body the most safe and effective pesticides were Bayer 73, Seven, NaPCP, and Copper sulfate but among those agents, Bayer 73 and NaPCP show relatively stronger effect in both Parafossarulus manchouricus and cercaria of liver fluke.
parasitology ; helminth ; trematode ; Clonorhcis sinensis ; chemotherapy ; Parafossarulus manchouricus ; Onchomelania ; cercaria ; toxicology ; Bayer 73 ; Nicotin ; NaPCP ; Sevin ; Parathion ; Copper sulfate ; Lindane

To compare the efficiency, success rate and abortion time of applications of intravaginal misoprostol versus intravenous Sulprostone(Nalador) for mid-trimester pregnancy termination. Eighty three patients between 17-29 weeks of gestation with medical, obstetric, or genetic reasons for termination of pregnancy were randomized to receive either 50 ug tablets of misoprostol placed in the posterior vaginal fomix or 1,000ug sulprostone intravenously diluted I L of isotonic saline solution given as a 12-h infusion. Among eighty three patients recruited, fourty five patients received misoprostol and thirty eight patients received sulprostone intravenously. The average interval from start of induction to vaginal delivery was 13.35+/-3.34 hours in misoprostol group and 21.14+/-6.64 hours in the sulprostone group. The success rate of complete termination within 12 and 24 hours in misoprostol group were 57.7%, 93.3%, respectively, while in sulprostone group were 15.8%, 92.1% respectively. Oxytocin augumentation was 6.7% in misoprostol group and 7.9% in the sulprostone group. No serious complication occurred. Intravaginal misoprostol appears to be acceptably safe and effective agents for second trimester pregnancy termination. Misoprostol has the advantage of being inexpensive, easily stored and readily available. The regimen of 100 ug misoprostol inserted intracervicovaginally every 8 hours is the optimal method for pregnancy termination.
Female ; Humans ; Misoprostol* ; Oxytocin ; Pregnancy ; Pregnancy Trimester, Second* ; Sodium Chloride ; Tablets

No abstract available.
Semen Analysis* ; Semen*

No abstract available.
Twins, Conjoined*

No abstract available.
Hirschsprung Disease*

No abstract available.
Endophthalmitis* ; Vibrio*

No abstract available.

No abstract available.
Semen Analysis* ; Semen*

The authors have reviewed 46 cases (38 males and 8 females) with ligamentous injuries of the knee in the Department. of Orthopaedic Surgery, St. Mary's Hostpital, Catholic Medical College and Center, during the period from Feb. 1983 to May 1985. The patients were divided into two groups according to the two different postoperative rehabilitation programs. In one group, rehabilitation was begun with limited motion brace from 2nd week postoperatively (Group I). In another group, a long leg circular cast was applied for 6 weeks postoperatively, followed by rehabilitation (Group II). All patients were allowed to bear full weight in 12 weeks postoperatively and were recommended to keep appling braces for at least 6 months postoperatively. Sports or other vigorous activities were allowed in one year postoperatively. Primary repair was performed in 14 cases in Group I (66.7%) and in 17 cases in Group II (68.0%). Reconstruction of ligament was performed in 7 cases in Group I (33.3%) and in 8 cases in Group II (32.0%). The results were analyzed in terms of range of motion, pain, instability and muscle power in each group according to O'Donoghue. The results were as follows: 1. Three months after operation, over 120 degrees in flexion was achieved in 18 cases in Group I (85.7%) and in 7 cases in Group II (28.0%). The recovery of range of motion was achieved earlier in Group I than in Group II. 2. Three months after operation, extension lag was seen in only 2 cases in Group I, all of which were below 10 degrees, and 13 cases in Group II of which 10 cases had extension lag of over 10 degrees. The recovery of muscle power was achieved earlier in Group I than in Group II. 3. Overall results showed “excellent” in 17 out of 21 cases in Group I (80.9%) and in 12 out of 25 cases in Group II (48.0%). In conclusion, the limited motion brace was effective in early recovery of range of motion and muscle power, without any significant loss of stability, after repair or even reconstruction of theligamenta of the knee, regardless of the type of injury, although the number of posterior cruciate ligament tears were too small to come to a concrete conclusion.
Braces ; Humans ; Knee ; Leg ; Ligaments ; Male ; Posterior Cruciate Ligament ; Range of Motion, Articular ; Rehabilitation ; Sports ; Tears

The result of forty cases of rheumatoid arthritis according to New York criterion, who underwent multiple operations(up to 10) in multiple joints hetween 1983 and 1986 were evaluated in 3 years and 8 months in average(range; 18 months to 5 years 2 months)postoperatively. The joints operated upon were knee, ankle, shoulder, elbow, wrist and finger joints. The surgery performed were 65 arthroscopic synovectomies, 17 total joint replacement(16 knees and 1 elbow) and 7 arthrodesis(1 knee, 1 ankle and 5 wrists). There were 10 males and 30 females, 27 “clsssic” and 13 “definite” rheumatoid arthritis according to the classification of American Rheumatism Association.Functional capacity of the patient was graded as I, II,III and IV according to the ARA. The final clinical results were graded as “excellent”, “good”, “fair” and “poor” according to the modified citeria of Sledge et al(20). The relationship between number of cases of recurred synovitis and various factors such as sex, classification according to the ARA, number of joints involoved and extent of synovectomy in the knee joint was analyzed statistically with chi-square test of the contingency table.The results are as follows; 1. The final results were 22 “excellent”(55.0%), 16 “good”(40.0%) (altogether 95% of cases were satisfactory) and 2 fair (5.2%), but there was no “poor” result. 2. All cases showed functional improvement, the commonest mode of improvement being from preoperative grade II to postoperative grade I(19 out of 40 cases, 47.5%). 3. There were 9 cases of recurrence of synovitis following arthroscopic synovectomy(22.5 %). They were controlled by medication in 2 cases, and by reoperation in 5 cases (resynovectomy ; 3, joint replacement; 1, arthrodesis ; 1). 4. The factors such as sex, classification and number of joints involved were not significantly correlated c the recurrence rate although there was a tendency of frequent recurrences in cases of female, classic RA and multiple joint involovement (P>0.05). 5. In the knee joint there was significantly less recurrence rate in total synovectomy cases (1/20, S.0%) than in anterior synovectomy cases (7/22, 31.8%) (P<0.01). 6. There was no recurrence following total joint replacment or arthrodesis. In conclusion the combined surgery of arthroscopic synovectomy, joint replacement and arthrodesis in the multiple joints was effective in relief of pain and effusion and improvement of functional capcity of the rheumatoid patient if proper medical treatment was given postoperatively.
Ankle ; Arthritis, Rheumatoid ; Arthrodesis ; Classification ; Elbow ; Female ; Finger Joint ; Humans ; Joints ; Knee ; Knee Joint ; Male ; Recurrence ; Reoperation ; Rheumatic Diseases ; Shoulder ; Synovitis ; Wrist