1.Pulmonary Adenocarcinoma of Fetal Type: Report of a case.
Soon Bong CHUNG ; Il Seon LEE ; Hee Kyung CHANG ; Bang HUR ; Man Ha HUH
Korean Journal of Pathology 1992;26(2):186-190
Adenocarcionma of fetal type is in lung is a newly recognized malignant tumor sharing morphologic features with the epithelial component of the pulmonary blastoma devoid of sarcomatous component. We present a case of adenocarcinoma of fetal type in a 28-year-old female, consisting of numerous branching tubules or glands and morula-like epithelial complexes. Histologically, the tubules and glands were composed of glycogne-rich nonciliated epithelial cells showing in part argyrophilia. Some of tubular and morula-like epithelial cells revealed immunoreactivity for neuron-specific enolase. We report this case with a review of literatures with special references on the histogenisis. This report is the pathologically confirmed second case of the pulmonary adenocarcinoma of fetal type in Korea, following the report of Cho and Lee, 1990.
Female
;
Humans
;
Adenocarcinoma
2.Uterine Tumor Resembling Ovarian Sex-Cord Tumor: A case report.
Il Seon LEE ; Soon Bong CHUNG ; Bang HUR ; Man Ha HUH
Korean Journal of Pathology 1992;26(2):180-185
The authors report a case of uterine tumor resembling ovarian sex-cord tumor in a 31-year-old woman with emphasis on immunohistochemistry. Histologically this case showed identical features to a well-recognized endometial stromal tumor except for focal epithelial-like differentiation that resembled sex-cord tumors of the ovary. The sex-cord like differentiation of tumor cells were manifested by trabeculae, plexiform cords, and gland-like pattern. We diagnosed this case, according to the features described by Clement and Scully(1976), as uterine tumor resembling ovarian sex-cord tumor, group I. Although the histogenesis of this tumor is unclarified, most authors believe that this tumor may be originated from multipotent mesenchymal cells of the uterus. On immunohistochemical stains, Desmin was uniformly reactive in epithelial-like cells and in focal areas of endometrial stromal sarcoma-like component. Vimentin was partly reactive in all tumor components, however EMA was non-reactive.
Female
;
Humans
3.Two Cases of Gaucher's Disease in Brothers.
Jeong Sick MIN ; Il Whan KIM ; Dae Young HWANG ; Hyun Gi JEONG ; Jae Sun PARK ; In Sun JUN ; Man Ha HUH
Journal of the Korean Pediatric Society 1984;27(6):628-634
No abstract available.
Gaucher Disease*
;
Humans
;
Siblings*
4.A Case of Addison's Disease: Partial Recovery of Adrenocortical Function Following Antituberculous Medication.
Kang Seo PARK ; Jong Il JUN ; Kyung Keun CHO ; Mi Sook KIM ; Jin Man HUH ; Man Soon BAEK ; Moon Jun NA
Journal of Korean Society of Endocrinology 1997;12(4):642-646
Addisons disease is relatively rare than secondary adrenal insufficiency and result from progressive adrenocortical destruction. The common causes are idiopathic autoimmune atrophy and tuberculosis of adrenal glands. It is generally regarded as incurable in the sense that substitution therapy is required for the rest of the patients life. We report a case of tuberculous primary adrenal insufficiency which was confirmed by biopsy. This case was treated with antituberculous medication and showen to have improved adrenocortical function after six months.
Addison Disease*
;
Adrenal Glands
;
Adrenal Insufficiency
;
Atrophy
;
Biopsy
;
Humans
;
Tuberculosis
5.Results of Minimal Incision Distal Metatarsal Osteotomy for Moderate to Severe Hallux Valgus.
Jung Wook HUH ; Il Soo EUN ; Young Chul KO ; Man Jun PARK ; Sook Hyun PARK
Journal of Korean Foot and Ankle Society 2015;19(2):51-57
PURPOSE: Minimal incision distal metatarsal osteotomy (MIDMO) is known to be an effective surgical procedure for mild to moderate hallux valgus. However, the result of MIDMO on moderate to severe hallux valgus is controversial; therefore, we investigated the radiological and clinical results of MIDMO on moderate to severe hallux valgus. MATERIALS AND METHODS: We reviewed 51 feet (48 patients) with moderate to severe hallux valgus. The mean age was 67.0 years and the mean follow-up period was 32.2 months. Radiological data of hallux valgus angle, first intermetatarsal angle, and distal metatarsal articular angle on plain radiographs were analyzed. Recurrence, union, lateral translation of distal fragment and angulation were also analyzed. The clinical data were obtained using American Orthopaedic Foot and Ankle Society (AOFAS) score of preoperation and last follow-up. Receiver operating characteristic (ROC) curve was used to determine a cut-off value. RESULTS: The mean hallux valgus angle measured at preoperation was 37.7o and 15.9degrees at last follow-up. The mean first intermetatarsal angle of preoperation and last follow-up were 15.2degrees and 8.3degrees. The mean distal metatarsal articular angle changed from 12.6degrees at preoperation to 7.8degrees at last follow-up. Preoperative hallux valgus angle (p=0.0051) and distal metatarsal articular angle (p=0.0078) were statistically significant factors affecting postoperative AOFAS score. Cut-off value of each was 37degrees and 13degrees, respectively. Lateral translation of distal fragment in 5 recurrent cases was 23.0% compared to 45.3% of 46 non-recurrent cases. The result was statistically significant and the cut-off value was 38%. CONCLUSION: Sufficient lateral translation over 38% in MIDMO on moderate to severe hallux valgus patients with preoperative hallux valgus angle under 37degrees and distal metatarsal articular angle under 13degrees can lead to good clinical results without recurrence.
Ankle
;
Follow-Up Studies
;
Foot
;
Hallux Valgus*
;
Humans
;
Metatarsal Bones*
;
Osteotomy*
;
Recurrence
;
ROC Curve
6.Audiovisual stimulation with synchronized pulsed tones and flickering lights set at a delta frequency can induce a sedative effect.
Jong Man KANG ; Byungdo LEE ; Hyup HUH ; Wha Ja KANG ; Moo Il KWON
Korean Journal of Anesthesiology 2011;61(1):93-94
No abstract available.
Hypnotics and Sedatives
;
Light
7.Rapid Expansion and Auto-Grafting Efficiency of Porcine Full Skin Expanded by a Skin Bioreactor Ex Vivo.
Man Il HUH ; Sun Hee AN ; Hwi Gang KIM ; Yun Jeong SONG ; Eun Chang CHOI ; Sang Hyun AN ; Woo Sung CHOI ; Jeung Soo HUH ; Jeong Ok LIM
Tissue Engineering and Regenerative Medicine 2016;13(1):31-38
Full skin auto-grafts are required for reconstruction of skin burns and trauma scars. However, currently available clinical approaches such as sheet skin graft, mesh skin grafts, artificial skin graft, and in vivo skin expansion have limitations due to their potential danger for secondary damage and scar formation at the donor site, and discomfort during skin expansion. We developed an advanced bioreactor system and evaluated its function in skin expansion using porcine full skin. The reactor was designed as a pneumatic cylinder type, was programmed to adjust the pressure and the operating time. The system was composed of culture chamber unit, environmental control unit, and monitoring unit. Skins were expanded at 200 kPa pneumatic force and the expanded skins were analyzed by immunohistochemistry and histology. Furthermore we carried out auto-grafting experiment of the expanded skins in vivo using Yucatan pigs and skins were harvested and histologically analyzed after 8 weeks. The results showed that the bioreactor expanded skins to 160% in 4 hours. Histological analysis of the expanded skins revealed that epidermal cells and dermal fibroblasts were viable and remained integrity. The results of auto-grafting experiment indicated that fibrosis and scars were not detected in the grafted skins. This study demonstrates that the newly developed skin bioreactor enabled to obtain large sized full skin rapidly and successful grating.
Bioreactors*
;
Burns
;
Cicatrix
;
Fibroblasts
;
Fibrosis
;
Humans
;
Immunohistochemistry
;
Skin*
;
Skin, Artificial
;
Swine
;
Tissue Donors
;
Transplants
8.Clinical Characteristics of Acute Appendicitis in Kidney Transplant Recipients.
Han Hee LEE ; Jung Jun LEE ; Man Ki JU ; Myoung Soo KIM ; Kyu Ha HUH ; Eyi Sang YOON ; Dong Jin JOO ; Soo Jin KIM ; Soon Il KIM ; Yu Seun KIM
The Journal of the Korean Society for Transplantation 2009;23(3):233-236
BACKGROUND: Appendicitis is a common surgical disease. There are many problems for the early diagnosis of acute appendicitis in kidney transplant patients; differential diagnosis for acute rejection, limitation in imaging study, problems of immunosuppressant and non-characteristic symptoms. METHODS: We reviewed medical records and transplant database of 2,947 renal transplant patients between April, 1979 and September, 2009 retrospectively. Patient's characteristics, diagnostic methods for appendicitis and operative/postoperative progresses were analyzed. RESULTS: Of the 2,947 renal transplant patients, there were 15 (0.51%, 13 males and 2 females) acute appendicitis patients. Mean age at the diagnosis of appendicitis was 37.2+/-10.1 years. Fourteen (93.3%) patients suffered from prodromal symptom, such as abdominal pain, direct or rebound tenderness, nausea and vomiting. There were 12 (80%) patients with leukocytosis (WBC count >10,000/microliter). Computed tomography scans were performed in 5 (33.4%) patients for diagnosis. Laparoscopic appendectomies were applied for 8 (53.4%) patients. In pathologic diagnosis, 2 cases were reported as 'non pathologic diagnosis' complications occurred in 2 patients as remnant appendicitis and pancreatitis. However, there was no patient with mortality and renal failure during the hospitalization. CONCLUSIONS: There were no significant differences between the transplant patients and the general population in the incidence, clinical features, diagnosis and postoperative progresses of acute appendicitis.
Abdomen, Acute
;
Abdominal Pain
;
Appendectomy
;
Appendicitis
;
Diagnosis, Differential
;
Early Diagnosis
;
Hospitalization
;
Humans
;
Incidence
;
Kidney
;
Kidney Transplantation
;
Leukocytosis
;
Male
;
Medical Records
;
Nausea
;
Pancreatitis
;
Prodromal Symptoms
;
Rejection (Psychology)
;
Renal Insufficiency
;
Retrospective Studies
;
Transplants
;
Vomiting
9.Immunologic Control for Polyomavirus Infection after Kidney Transplantation.
Hyung Joon AHN ; Man Ki JU ; Hyeon Joo JEONG ; Myoung Soo KIM ; Hyon Suk KIM ; Kyu Ha HUH ; Jong Hoon LEE ; Soon Il KIM ; Yu Seun KIM
The Journal of the Korean Society for Transplantation 2006;20(2):193-200
Purpose: The purposes of this study were to compare the relative efficacy of urine decoy cell (UDC) and polymerase chain reaction (PCR) for the polyomavirus infection (PVI), and to search the efficacy of preemptive immunologic control for PVI in earlier stage before irreversible graft injury. Methods: Between Mar. 2003 to Sep. 2005, 265 patients were monitored for the PVI after kidney transplantation. Of the 265 patients, the results of preemptive immunologic modifications were searched among 222 recipients who had the complete data. Results: Of the total 222 patients, 75 patients (33.8%) were positive for UDCs in at least one examination. Overall cumulative incidence of PVI was 32.9%. According to the episode of acute rejection, the one year incidences of PVI were 51.4% and 29.5% in recipients with and without the episode of acute rejection, respectively (P=0.0047). Using decoy cells as a marker of PV viruria, cytology has a sensitivity of 57.1% and negative predictive value of 74.1%. The specificity and positive predictive value for viruria (not viral nephropathy) are 67.2% and 48.8%. False-negative results occurred in samples with suboptimal cellularity, and a low viral load. Three cases of PV nephropathy (PVN) were documented. From January 2001 to December 2002, when we did not prospectively monitor UDCs, 7 cases of PVN were documented among the 116 recipients. Conclusion: The combination test of UDC and PV PCR should be considered as screening test for PVI due to low positive predictive value of UDC. The modulation of net immunosuppression based on UDC values and PV viral loads may reduce the development of PVN.
Humans
;
Immunosuppression
;
Incidence
;
Kidney Transplantation*
;
Kidney*
;
Mass Screening
;
Polymerase Chain Reaction
;
Polyomavirus Infections*
;
Polyomavirus*
;
Prospective Studies
;
Sensitivity and Specificity
;
Transplants
;
Viral Load
10.Biphasic Calcium Phosphate and Local Autobone Mixed Graft in Lumbar Posterolateral Fusion.
Jung Wook HUH ; Young Chul KO ; Chul Young JUNG ; Il Soo EUN ; Man Jun PARK ; Min Woo KIM ; Keum Min HWANG ; Sook Hyun PARK
Journal of Korean Society of Spine Surgery 2014;21(3):103-108
STUDY DESIGN: Retroprospective study. OBJECTIVES: To evaluate the efficacy of biphasic calcium phosphate and local autobone mixed graft in cases of spinal stenosis and spondylolisthesis in posterolateral fusion by examining radiologic union rates and clinical outcomes. SUMMARY OF LITERATURE REVIEW: It can be a practical alternative to the use of tricalcium phosphate in hydroxyapatite as a graft aid since using hydroxyapatite mixture in lumbar spine fusion has been reported to lead to a high rate of bone union. MATERIALS AND METHODS: From July 2011 to February 2013, we followed up 107 patients who had lumbar posterolateral fusion using biphasic calcium phosphate composed of HA/TCP (60:40) and local autobone mixed graft. Of these patients, 64 had spinal stenosis and 43 had spondylolisthesis. The bone fusion rate was determined using Lenke's criteria and clinical outcomes were evaluated using Kim's method. RESULTS: In spinal stenosis, bone union was presented in 53 patients (of 64; 82.8%) and in spondylolisthesis, 35 patients (of 43; 81.4%). In spinal stenosis, the clinical outcomes resulted in 20 excellent, 34 good, 9 fair and 1 poor. (84.4%, excellent or good) In spondylolisthesis, the clinical outcomes resulted in 10 excellent, 25 good, 7 fair and 1 poor. (81.4%, excellent or good). CONCLUSION: Posterolateral fusion using biphasic calcium phosphate and local autobone mixed graft showed high rates of bone union and acceptable clinical outcomes, and is considered a satisfactory bone graft aid.
Calcium*
;
Durapatite
;
Humans
;
Spinal Stenosis
;
Spine
;
Spondylolisthesis
;
Transplants*