Nutritional support for patients who develop cancer is necessary to increase their food intake, which is often insufficient due to the adverse effects of anticancer drugs and radiation treatment. In December 2011, our center introduced Bocchiri meals for cancer patients to improve their quality of life and support ongoing treatment. In this study, we examined the efficacy of Bocchiri meals, which were developed to help increase the amount of food intake during cancer treatment. Target patients were those who could eat half or less than half of their daily required food intake, averaged over 3 days.Patients could order the meal 2 h before serving time and it was served at the temperature and amount that individual patients requested.We evaluated age, sex, main disease, use of anticancer drugs, radiation treatment, time taken to eat the Bocchiri meals, number of orders made, average energy intake before and after eating the Bocchiri meals, and rate of eating a Bocchiri Meal with a side menu order. Average energy intake was increased from 226.6±14.8 kcal with regular meals to 294.1±15.3 kcal with Bocchiri meals. Furthermore, a strong correlation was seen after the Bocchiri meals were introduced between the rate of eating Bocchiri meals with a side menu order and average energy intake. These results suggest that Bocchiri meals may be an effective supportive nutritional measure to enhance food intake among cancer patients.

Authors evaluated which factor among age, sex and season influences each Ryodoraku, and to what extent, using socalled healthy children.
METHOD
Ryodorakumeasurement was conducted on the same subjects in two different seasons. Comparison was done between groups divided according to their sex andage. The measured value of skin electro-resistance at the Ryodoraku representative measuring points and excitation-inhibition frequency were analyzed using single- and multi-variate data analysis.
RESULT
1) Each group showed slightly different Ryodoraku characteristics.
2) The differences among each group were greatest between the two seasons and rather big between years, however, small between male and female.
3) These tendencies werejobserved in both analyses using the measured values and using frequency.

Purpose
An organism receives internal and external stimuli successively. If the function of the organism become abnormal, the abnormality is projected on its body surface. Accordingly the condition of the organism's function can be grasped by palpation or other objective measuring methods.
Among these methods, we commonly put skin-electroresistance meters in clinical use.
However, the variation of the organism's function in a healthy condition has not been quantitatively grasped, while there are data on the variation of the values obtained from sick patients.
The purpose of this study is to investigate the variation of values obtained from subjects in a healthy condition in order to grasp the abnormal variation of values more exactly.
Method
Subjects were sixth-year pupils of Osaka Municial Elementary School of Higashi Awaji. Neurometory was sutomatically recorded at the regular points 0.75 second after the onset of the measurement, with a neurometer (Improved Model D-401; Noiro Ika Kogyo Inc.) adjusted at 12V, 200mV.
Result
Excited H₆ large intestine channels, and inhibited F₂ liver channels and F₆ stomach channels were frequently seen as in the same time of other years.
Unlike adult subjects, the current intensity was low in the Yong meridians of the hand (H4, 5, 6), and high in the Yin meridians of the hand and the foot (H1, 2, 3, F1, 2, 3).

It is presumed that oversensitivity to cold is derived from the imbalance of the autonomic nervous system. As a result of the cold condition, the patient may complain of various other problems as well. According to oriental medicine, the main origin of oversensitivity to cold is the invasion of cold, an external evil. In neurometry, this symptom is depicted by low measurement values. Before each treatment session we performed neurometry to assess the patient's condition. Then we performed general Ryodoraku regulation therapy, using a 60mm length, 0.24mm diameter needle as a 200μA (12V) negative electrode for 7 seconds. withI the objective of tonifying and warming the body. In addition, we performed half-rice grain size moxibustion 7 flashing moxas on the special effective extraordinary meridian points. Hanfeng, Lisanli, and main meridian points Fengmen, Zhishi. Neurometry revealed that oversensitivity to cold is related to values of the F, Ryodoraku which are lower than the normal physiological range. The treatment indicated by neurometry proved to be successful in increasing the F, Ryodoraku values.

In order to study the physical fitness of rural children in Gifu prefecture, a total of 128 rural boys and girls aged 8-14 years old in the Tokuyama-Elementary School and-Middle School, which are in a far rural district from busy civilized urban distriet, were measured for the developmental status, i. e, physique, examination of physical fitness, maximum working capacity, cardiorespiratory function and urinary excretion in summer, 1962, and the comparison was made on the results obtained there with those of the average Japanese children of the same age.
The results obtained were as follows:
1) Little or no difference was found between physical development of rural children and that of average Japanese boys and girls ; i. e, the physique of rural children was not superior nor inferior to the value of the average Japanese children.
2) The record of sprint games, such as 50m-sprint-run, broad jumping, ball throwing, Sargent-jump, grip strength and back strength of rural children was lower than that of the Japanese average. Whereas, the endurance ability measured with a long-distance running (1500m for boys and 1000m for girls) was tended to be higher in the rural children, especially in the girls, than the average Japanese value. However, no significant difference was presented in the flexibility test (forward bending of the upper-body in standing posture) between rural and average Japanese values.
3) The examination of cardiopulmonary function : i.e. E.C.G., blood pressure, heart rate, vital capacity and maximum expiratony flow rate exhibited no abnormal sign. The systolic and diastolic blood pressure tended to increase with age, but the heart rate tended to decrease. The examination of the urinary glucose, protein and occult-blood remained normal, and most of the urine pH of the girls were within the range between 6 and 7, whereas, those of boys were between 5 and 6.
4) The maximum working capacity (maximum oxygen intake, vital capacity) showeda linear increase proportional to age and physique (body height, body weigmt, body surface, etc, ) over the range of the age tested. Sexual difference appeared after 12 years of age.
5) The possibility was suggested that the maximum O₂ intake could be predicted from the vital capacity of the same individual regardless of age, sex and physique, and a theoretical background for that was discussed.

The purpose of this study was to examine total energy expenditure (TEE) in Japanese men under free-living conditions using various field methods, and compare these methods with the doubly labeled water method (DLW) . Ten Japanese men, aged 24.2±1.8 (mean±SD) yrs, were studied for 14 consecutive days. TEE was assessed by DLW, activity record method (AR ; using relative metabolic rate and calculated basal metabolic rate), heart rate monitoring methods (Two-line and FLEX-HR methods), and accelerometer method (AC) . Energy intake (EI) was also evaluated over the same period. Although TEE estimated by AR (2730±139 kcal⋅day^-1), Two-line (2925±433 kcal⋅day^-1), and FLEX-HR (2949±506 kcal⋅day^-1) did not differ significantly from the TEE determined by DLW (2910±524 kcal⋅day^-1), there was no significant relationship between each of these methods and DLW. In addition, El (2963±482 kcal⋅day^-1) and TEE determined by DLW were similar, and there was a significant correlation (r=0.809, P<0.01) . Compared with DLW, AC (2697±541 kcal⋅day^-1) underestimated TEE at the group level ; however, AC was the only method to show a significant correlation with DLW (r=0.871, P<0.001) . Therefore, it seems possible that AC would accurately estimate TEE at the individual level by improving both the instrument and its methodology.

We have carried out a health developing project for three years at two flat rural areas in Ibaraki prefecture, O in Ushiku town and N in Iwai city, taking female farmers as the subjects.
As a result, people in these areas obtained by developing reciprocal assistance a belief in selfsupport and knowledge of diseases, which lead to remarkable progress of their health such as improvement of nutrition and cosolidation of agricultural and life environment. Some observations in the study are discussed below.
1) In the two areas, the number of people with no abnormality increased while those requiring care decreased, The number of people to be treated or under treatment was nearly unchanged, probably because of chronic deseases. No death and complication occured during the three years.
2) Owing to the difference between O and N areas in the age structure of examinees, areal characteristics and types of agricultural products, the results of health examinations in these two areas were somewhat different.
3) The health developing project will become more effective if male farmers participate together with the female farmers.
4) Continuation of the health care activity in these areas will establish voluntary organizations of residents.

Spinal cord injury after successful operation of the thoraco-abdominal aorta is an unpredictable complication which negatively affects the patient's quality of life. The main cause of spinal cord injury has been reported to be peroxidation of lipids. Edaravone, a free radical scavenger, has been used in the acute phase of cerebral infarction to ameliorate the brain damage. The aim of the present study was to evaluate the protective effect of edaravone on the neurological and histological outcome, and to examine the method of its administration so as to obtain the better effect, using animal models with ischemic spinal cord. Three groups of rabbits underwent surgical exposure of the abdominal aorta that was clamped for 20min to achieve spinal cord ischemia. Group A (n=6, control group) was given no medication. In group B (n=6), edaravone (3mg/ml saline/kg body weight) was administered intravenously 30min after reperfusion. In group C (n=6), the same dose of edaravone was administered at 30min, 24h and 48h after reperfusion. Neurological status was clinically assessed, using Tarlov's score, at 24h, 48h and 1week after reperfusion. Somatosensory evoked potential was measured preoperatively, at 20min after ischemia, at 30min after reperfusion, and at 24h, 48h and 1week after operation. Spinal cord sections were examined histologically to determine the degree of neuronal damage given by ischemic-reperfusion. Group A presented paraplegia with marked neuronal necrosis. Groups B and C maintained better neurogical function than Group A (p<0.001), and Group C was much better than Group B (p<0.05). In the model rabbits with 20min of ischemia-reperfusion, systemic repetitious administration of edaravone was found to have a more protective effect than a single administration on the spinal cord neurons and glia cells both neurologically and histologically.

In cancer chemotherapy, it is very important to take into account the patient’s background. In recent years, a simple suspension method has attracted increased attention as a method that prevents changes in the stability and safety of various drugs. However, of 135 oral anticancer drugs, only 28 have been examined using this method, as of April 2013. In this study, we carefully investigated whether 53 oral anticancer drugs could be adapted to the simple suspension method, except for the 28 drugs that had already been previously reported. The results showed that most of these oral anticancer drugs could be adapted to the simple suspension method. Of seven drugs that were not adapted, six were generic drugs. In addition, it was clear that the evaluation of bicalutamide tablets was significantly different from our expected results. In conclusion, we were able to qualitatively assess all 53 oral anticancer drugs. This is equivalent to half of 107 untested drugs. These results provide useful information to cancer patients using oral anticancer drugs prepared using the simple suspension method.