A 40-year-old woman presented with Salmonella enteritidis endocarditis involving the mitral valve. A severe degree of congestive heart failure developed despite appropriate medical and antibiotic treatment, and resulted in urgent surgical intervention in the active phase of the infection. She underwent successful mitral valve replacement with a mechanical valve, followed by additional antibiotic infusion with adequate distribution to the biliary system to prevent late reactivation of the organism. Although antibiotic therapy is fairly effective for patients with Salmonella enteritidis, early rather than procrastinated surgical treatment is recommended to minimize damage to the valve and surrounding structures.