No abstract available.
Dantrolene* ; Malignant Hyperthermia*

Four cases of malignant hyperpyrexia were reported in Korea since 197I and three of these cases expired. We discuss here the four cases of malignant hyperpyrexia with clinical features and management, and the importance of early recorgnition and aggressive treatment of malignant hyperpyrexia are stressed.
Korea* ; Malignant Hyperthermia*

No abstract available.
Dantrolene ; Malignant Hyperthermia

No abstract available.
Dantrolene ; Malignant Hyperthermia

A male patient of 26 years old was received with multiple fracture by tranffic accident. Anesthesia was maintained with inhalation of isoflurance. Malignant hyperthermia (MH) was appeared after operation. The patient rehabilited after physical cooling, bedside persistence hematodialysis, hormone application and so on.
Anesthetics, Inhalation ; Humans ; Male ; Malignant Hyperthermia

Evans myopathy is a type of malignant hyperthermia showing characteristic distribution of myopathic changes. We present two cases of Evans myopathy, father and his son in a family. Five members of this family expired during ane sthesia and surgery and two of these cases were reported as the malignant hyperthermia. The muscle pathology shows moth-eaten appearance with or without unstained cores in NADH-TR stain and its difference between the father and his son is suggestive of rather progressive myopathy than static one. s
Fathers ; Humans ; Malignant Hyperthermia ; Muscular Diseases* ; Pathology

Anesthesiologists have been at the forefront of initiatives addressing perioperative patient safety. As anesthesia has no direct therapeutic benefit, its risk must be minimized. At times the surgery is simple but the patient’s condition complicates anesthetic management, increasing the risk for complications. This report describes the anesthetic management of an adult patient diagnosed with inclusion body myositis (IBM), a rare inflammatory degenerative myopathy, who initially presented with decreased motor function in both lower and upper extremities causing him to be bedbound for two years. Due to the progression of his disease, he eventually developed dysphagia, hence he was scheduled for esophagoscopy, cricopharyngeal Botox injection, and percutaneous endoscopic gastrostomy. As patients with IBM are at risk for exaggerated sensitivity to neuromuscular blockers and respiratory compromise, anesthesia was at the helm of a multidisciplinary team approach. The perioperative management centered on preoperative optimization, prevention of aspiration, avoidance of anesthetics that may trigger malignant hyperthermia, and prevention of postoperative pulmonary complication. The hospital course was uncomplicated and the patient was discharged well after one day. This report emphasizes how improvements in resources, technology, and healthcare delivery, especially in anesthesia, help prevent perioperative adverse events.
Patient Safety ; Myositis, Inclusion Body ; Malignant Hyperthermia

Fever (body temperature above 38℃) is relatively common during the first few days after general anesthesia. Postoperative fever is usually caused by the inflammation induced by surgery and resolves spontaneously; however, it can be a manifestation of a serious complication such as malignant hyperthermia. We report a case of postoperative hyperthermia (body temperature > 40℃) that was refractory to conventional anti-pyretic measures and finally resolved with dantrolene administration.
Anesthesia, General* ; Dantrolene* ; Fever ; Humans ; Inflammation ; Malignant Hyperthermia* ; Postoperative Period

Humans ; Abdomen ; Dantrolene ; East Asian People ; Malignant Hyperthermia

Malignant hyperthermia is a recently described syndrome with rapid progress and extreme rise in body temperature of unknown etiology and high mortality rate. A case is presented of a 16 year old healthy male patient in whom a minor orthopedic operation was performed under O2-N2O-halothane anesthesia with induction by pentothal sodium and succiny- lcholine. This was complicated by an abrupt high rise of body temperature and rigid extremities when the operation was almost completed. He died 3 hours after cessation of anesthesia without any effective response to active fever therapy. The clinical features and management of malignant hyperthernia are described and possible etiologic factors are discussed.
Adolescent ; Anesthesia ; Body Temperature ; Extremities ; Humans ; Hyperthermia, Induced ; Male ; Malignant Hyperthermia* ; Mortality ; Muscle Rigidity* ; Orthopedics ; Sodium ; Thiopental