1.Peripheral Osteoma of Palate.
Manas BAJPAI ; Deshant AGARWAL ; Manish KUMAR ; Malay KUMAR
Annals of the Academy of Medicine, Singapore 2016;45(3):110-112
Bone Neoplasms
;
diagnostic imaging
;
pathology
;
Female
;
Humans
;
Middle Aged
;
Osteoma
;
diagnostic imaging
;
pathology
;
Palate
;
diagnostic imaging
;
pathology
;
Radiography
2.Squamous Cell Carcinoma in Exstrophy of the Bladder.
Pramod Kumar SHARMA ; Praveen Kumar PANDEY ; Mukesh Kumar VIJAY ; Malay Kumar BERA ; Jitendra Pratap SINGH ; Kaushik SAHA
Korean Journal of Urology 2013;54(8):555-557
Exstrophy of the bladder is a rare congenital anomaly with an incidence of about 1 per 50,000 newborns. The malignant potential of the exstrophied bladder mucosa is well known; 95% are adenocarcinomas, and 3% to 5% are squamous cell carcinomas. Most of the malignant tumors (60%) associated with an exstrophy of the bladder occur during the fourth and fifth decades of life. Of the remaining, about 20% each occur after 60 years and before 40 years. Here we present a case in which squamous cell carcinoma developed in an unrepaired exstrophy of the bladder. We present the management of the case and a brief review of the literature.
Adenocarcinoma
;
Bladder Exstrophy
;
Carcinoma, Squamous Cell
;
Humans
;
Incidence
;
Infant, Newborn
;
Mucous Membrane
;
Urinary Bladder
;
Urinary Bladder Neoplasms
3.Leukemic stromal hematopoietic microenvironment negatively regulates the normal hematopoiesis in mouse model of leukemia.
Pratima BASAK ; Sumanta CHATTERJEE ; Prosun DAS ; Madhurima DAS ; Jacintha Archana PEREIRA ; Ranjan Kumar DUTTA ; Malay CHAKLADER ; Samaresh CHAUDHURI ; Sujata LAW
Chinese Journal of Cancer 2010;29(12):969-979
BACKGROUND AND OBJECTIVELeukemic microenvironment has a major role in the progression of leukemia. Leukemic cells can induce reversible changes in microenvironmental components, especially the stromal function which results in improved growth conditions for maintaining the malignant leukemic cells. This study aimed to investigate the survival advantage of leukemic cells over normal hematopoietic cells in stromal microenvironment in long term.
METHODSThe mice were injected intraperitoneally with N-N' ethylnitrosourea (ENU) to induce leukemia; the mice received injection of normal saline were used as control. At 180 days after ENU induction, the mice were killed and the bone marrows were cultured for 19 days. Colony-forming assays were used to analyze the formation of various cell colonies. The expression of Sca-1, CD146, VEGFR2, CD95, pStat3, pStat5, and Bcl-xL in marrow cells were detected by flow cytometry.
RESULTSLong-term leukemic bone marrow culture showed abnormal elongated stromal fibroblasts with almost absence of normal hematopoietic cells. Adherent cell colonies were increased, but CFU-F and other hematopoietic cell colonies were significantly decreased in leukemia group (P<0.001). Primitive progenitor-specific Sca-1 receptor expression was decreased with subsequent increased expression of CD146 and VEGFR-2 in leukemic bone marrow cells. Decreased Fas antigen expression with increased intracellular pStat3, pStat5 and Bcl-xL proteins were observed in leukemic bone marrow cells.
CONCLUSIONSStromal microenvironment shows altered morphology and decreased maturation in leukemia. Effective progenitor cells are decreased in leukemia with increased leukemia-specific cell population. Leukemic microenvironment plays a role in promoting and maintaining the leukemic cell proliferation and survivability in long term.
Animals ; Antigens, Ly ; metabolism ; Bone Marrow Cells ; metabolism ; pathology ; CD146 Antigen ; metabolism ; Cell Count ; Cells, Cultured ; Colony-Forming Units Assay ; Erythroid Precursor Cells ; metabolism ; pathology ; Ethylnitrosourea ; Female ; Fibroblasts ; metabolism ; pathology ; Granulocyte-Macrophage Progenitor Cells ; metabolism ; pathology ; Granulocytes ; metabolism ; pathology ; Hematopoiesis ; Hematopoietic Stem Cells ; metabolism ; pathology ; Leukemia ; chemically induced ; metabolism ; pathology ; Male ; Membrane Proteins ; metabolism ; Mice ; Myeloid Progenitor Cells ; metabolism ; pathology ; Phenotype ; STAT3 Transcription Factor ; metabolism ; STAT5 Transcription Factor ; metabolism ; Tumor Microenvironment ; physiology ; Vascular Endothelial Growth Factor Receptor-2 ; metabolism ; bcl-X Protein ; metabolism ; fas Receptor ; metabolism
4.Noncommunicable Disease Risk Factors Among Adolescent Boys and Girls in Bangladesh: Evidence From a National Survey
Nushrat Jahan URMY ; Md. Mokbul HOSSAIN ; Abu Ahmed SHAMIM ; Md. Showkat ALI KHAN ; Abu Abdullah MOHAMMAD HANIF ; Mehedi HASAN ; Fahmida AKTER ; Dipak Kumar MITRA ; Moyazzam HOSSAINE ; Mohammad AMAN ULLAH ; Samir Kanti SARKER ; SM Mustafizur RAHMAN ; Md. Mofijul ISLAM BULBUL ; Malay Kanti MRIDHA
Osong Public Health and Research Perspectives 2020;11(6):351-364
Objectives:
To assess the prevalence of noncommunicable disease (NCD) risk factors and the factors associated with the coexistence of multiple risk factors (≥ 2 risk factors) among adolescent boys and girls in Bangladesh.
Methods:
Data on selected NCD risk factors collected from face to face interviews of 4,907 boys and 4,865 girls in the national Nutrition Surveillance round 2018-2019, was used. Descriptive analysis and multivariable logistic regression were performed.
Results:
The prevalence of insufficient fruit and vegetable intake, inadequate physical activity, tobacco use, and being overweight/obese was 90.72%, 29.03%, 4.57%, and 6.04%, respectively among boys; and 94.32%, 50.33%, 0.43%, and 8.03%, respectively among girls. Multiple risk factors were present among 34.87% of boys and 51.74% of girls. Younger age (p < 0.001), non-slum urban (p < 0.001) and slum residence (p < 0.001), higher paternal education (p = 0.001), and depression (p < 0.001) were associated with the coexistence of multiple risk factors in both boys and girls. Additionally, higher maternal education (p < 0.001) and richest wealth quintile (p = 0.023) were associated with the coexistence of multiple risk factors in girls.
Conclusion
The government should integrate specific services into the existing health and non-health programs which are aimed at reducing the burden of NCD risk factors.
5.Noncommunicable Disease Risk Factors Among Adolescent Boys and Girls in Bangladesh: Evidence From a National Survey
Nushrat Jahan URMY ; Md. Mokbul HOSSAIN ; Abu Ahmed SHAMIM ; Md. Showkat ALI KHAN ; Abu Abdullah MOHAMMAD HANIF ; Mehedi HASAN ; Fahmida AKTER ; Dipak Kumar MITRA ; Moyazzam HOSSAINE ; Mohammad AMAN ULLAH ; Samir Kanti SARKER ; SM Mustafizur RAHMAN ; Md. Mofijul ISLAM BULBUL ; Malay Kanti MRIDHA
Osong Public Health and Research Perspectives 2020;11(6):351-364
Objectives:
To assess the prevalence of noncommunicable disease (NCD) risk factors and the factors associated with the coexistence of multiple risk factors (≥ 2 risk factors) among adolescent boys and girls in Bangladesh.
Methods:
Data on selected NCD risk factors collected from face to face interviews of 4,907 boys and 4,865 girls in the national Nutrition Surveillance round 2018-2019, was used. Descriptive analysis and multivariable logistic regression were performed.
Results:
The prevalence of insufficient fruit and vegetable intake, inadequate physical activity, tobacco use, and being overweight/obese was 90.72%, 29.03%, 4.57%, and 6.04%, respectively among boys; and 94.32%, 50.33%, 0.43%, and 8.03%, respectively among girls. Multiple risk factors were present among 34.87% of boys and 51.74% of girls. Younger age (p < 0.001), non-slum urban (p < 0.001) and slum residence (p < 0.001), higher paternal education (p = 0.001), and depression (p < 0.001) were associated with the coexistence of multiple risk factors in both boys and girls. Additionally, higher maternal education (p < 0.001) and richest wealth quintile (p = 0.023) were associated with the coexistence of multiple risk factors in girls.
Conclusion
The government should integrate specific services into the existing health and non-health programs which are aimed at reducing the burden of NCD risk factors.