In order to study whether there is any relation between the cause of anemia in rural women and environmental factor from the epidemiological standpoint, we have followed up the seasonal change of the blood properties (GB, Hb, Ht, R, Serum iron) of 3 groups of women in different working and living circumstances.
The results revealed a remarkable tendency to increase the values of the blood properties excluding serum iron in winter and to decrease in summer. The degree of seasonal change was found to be greater in rural women than that in factory workers. And among the factory workers, the married had more change than the unmarried, the rural residents than the urban. And among the rural women, only the establishmental gardeners who were especially busy in winter showed a tendency to decrease the values of the blood properties in winter.
From these data, we can see that the seasonal change of the burden of agricultural work and the change of dietary life actually have direct influence on the change of the blood properties.

Nowadays the agricultural production system in the farm area has remarkably been changed and this has influenced the farmers in many aspects of life.
We tried by epidemiologic cross-sectional survey to ascertain the health level of 6, 597 farmers, who are self-supporting and middle class in the sixty-seven different districts of Kumamoto Prefecture. It is noticeable that judging from the difference of districts, the health level of the farmers who have a big gricultural production is low, and judging from the difference of the class, that of the farmers who have other jobs besides agriculture is low, too In general, the health level of males is relatively higher than that of females, but the health level of males is higher than that of females, depending on the class difference.
Generally speaking, we noticed that the health level of female is very low, and at the same time the variation of the health level of females is more remarkable than that of males, depending on the quality of the district in which they live.
These resutls of these investigations should be utilized as the basic materials source for a prospective survey of changing farm village from now.

The human gut microbiota changes under the influence of environmental and genetic factors, affecting human health. Extensive studies have revealed that the gut microbiome is closely associated with many non-intestinal diseases. Among these, the influence of the gut microbiome on cancer biology and the efficacy of cancer therapy has attracted much attention. Prostate cancer cells are affected by direct contact with the microbiota of local tissues and urine, and a relationship between prostate cancer cells and the gut microbiota has been suggested. In the human gut microbiota, bacterial composition differs depending on prostate cancer characteristics, such as histological grade and castration resistance. Moreover, the involvement of several intestinal bacteria in testosterone metabolism has been demonstrated, suggesting that they may affect prostate cancer progression and treatment through this mechanism. Basic research indicates that the gut microbiome also plays an important role in the underlying biology of prostate cancer through multiple mechanisms owing to the activity of microbial-derived metabolites and components. In this review, we describe the evidence surrounding the emerging relationship between the gut microbiome and prostate cancer, termed the “gut-prostate axis.”