1.A Case of Primary Racemose Hemangioma Discovered from Abnormal Chest X-ray Finding
Ken TOMOOKA ; Makoto NAKAO ; Seiji KAMEI ; Yuto SUZUKI ; Yusuke SAKAI ; Sousuke ARAKAWA ; Yusuke KAGAWA ; Ryota KUROKAWA ; Hidefumi SATO ; Yoshimi HORIKAWA ; Hideki MURAMATSU
Journal of the Japanese Association of Rural Medicine 2017;66(1):79-85
A 56-year-old woman was referred to our hospital because of an abnormal finding in the right pulmonary hilum on chest X-ray. Enhanced chest computed tomography showed hyperplastic bronchial arteries dilating and winding around the trachea and bronchi. A racemose hemangioma of the bronchial artery with multiple bronchial artery aneurysms (diameter <20mm) was seen displacing the trachea and both main bronchi. Bronchoscopy showed submucosal tumor-like lesions at the distal trachea and in both main bronchi, and a dusky-red elevated pulsatile lesion at the orifice of the left B3b+c. We performed coil embolization of the bronchial artery aneurysm to prevent abrupt rupture of the bronchial aneurysm.
2.Development of a Format to Record Clinical Experiences of Trainees during the Initial Two-year Period of Postgraduate Clinical Training; A Study of Self-evaluation by Jichi Medical School Graduates.
Yoshiyuki MINOWA ; Michiyasu YOSHIARA ; Yuko MIYAKE ; Makoto NIIKURA ; Megumi MATSUMOTO ; Mikihisa FUJII ; Akiyoshi KASHII ; Saichi HOSODA ; Yasuo KAGAWA ; Yukio HIRAYAMA ; Taroo TAMADA
Medical Education 1996;27(1):37-47
A self-reporting questionnaire was designed and sent to our Jichi Medical School graduates each year since 1980, in order to investigate clinical competence. The format was designed based on several major reports concerning postgraduate clinical training in primary medical care. We found that more than 70% of Jichi Medical School graduates trained in the multi-specialty rotation style in general hospitals that were certified by the Ministry of Health and Welfare. Our results also suggested that these graduates obtained a relatively high level of clinical competence in performing physical examinations, basic laboratory testing, clinical procedures, and various treatments.
3.Development of a Format to Record Clinical Experiences of Trainees during the Initial Two-year Period of Postgraduate Clinical Training. A Study of the Validity and Reliability of Technical Items in the Self-reporting Questionnaire.
Yoshiyuki MINOWA ; Michiyasu YOSHIARA ; Yuko MIYAKE ; Makoto NIIKURA ; Megumi MATSUMOTO ; Mikihisa FUJII ; Akiyoshi KASHII ; Saichi HOSODA ; Yasuo KAGAWA ; Yukio HIRAYAMA ; Taroo TAMADA
Medical Education 1996;27(2):99-103
A self-reporting questionnaire was designed and sent to our Jichi Medical School graduates each year since 1980, in order to investigate clinical competences attained in certain technical items. The responses from graduates of classes 1984 through 1987 were analysed, and the questionnaire was found to be highly reliable and moderately valid. The coefficient variable was 0.942, and the relevant variable was 0.934 using the half-split method. The content was clear, because items in the questionnaire were selected from published official reports. In the construction validity, 4 meaningful groups of items were found by factor-analysis. Yearly analysis using such a questionnaire may clarify some of the problems experienced by trainees and training hospitals, and would encourage the trainees to undergo a process of selfevaluation.
4.Association Between the Cool Temperature-dependent Suppression of Colonic Peristalsis and Transient Receptor Potential Melastatin 8 Activation in Both a Randomized Clinical Trial and an Animal Model
Satoshi SUGINO ; Ken INOUE ; Reo KOBAYASHI ; Ryohei HIROSE ; Toshifumi DOI ; Akihito HARUSATO ; Osamu DOHI ; Naohisa YOSHIDA ; Kazuhiko UCHIYAMA ; Takeshi ISHIKAWA ; Tomohisa TAKAGI ; Hiroaki YASUDA ; Hideyuki KONISHI ; Yasuko HIRAI ; Katsura MIZUSHIMA ; Yuji NAITO ; Toshifumi TSUJI ; Takashi OKUDA ; Keizo KAGAWA ; Makoto TOMINAGA ; Yoshito ITOH
Journal of Neurogastroenterology and Motility 2022;28(4):693-705
Background/Aims:
Several studies have assessed the effect of cool temperature on colonic peristalsis. Transient receptor potential melastatin 8 (TRPM8) is a temperature-sensitive ion channel activated by mild cooling expressed in the colon. We examined the antispasmodic effect of cool temperature on colonic peristalsis in a prospective, randomized, single-blind trial and based on the video imaging and intraluminal pressure of the proximal colon in rats and TRPM8-deficient mice.
Methods:
In the clinical trial, we randomly assigned a total of 94 patients scheduled to undergo colonoscopy to 2 groups: the mildly cool water (n = 47) and control (n = 47) groups. We used 20 mL of 15°C water for the mildly cool water. The primary outcome was the proportion of subjects with improved peristalsis after treatment. In the rodent proximal colon, we evaluated the intraluminal pressure and performed video imaging of the rodent proximal colon with cool water administration into the colonic lumen. Clinical trial registry website (Trial No. UMIN-CTR; UMIN000030725).
Results:
In the randomized controlled trial, after treatment, the proportion of subjects with no peristalsis with cool water was significantly higher than that in the placebo group (44.7% vs 23.4%; P < 0.05). In the rodent colon model, cool temperature water was associated with a significant decrease in colonic peristalsis through its suppression of the ratio of peak frequency (P < 0.05). Cool temperaturetreated TRPM8-deficient mice did not show a reduction in colonic peristalsis compared with wild-type mice.
Conclusion
For the first time, this study demonstrates that cool temperature-dependent suppression of colonic peristalsis may be associated with TRPM8 activation.
5.Initial 3-month dynamics of dehydroepiandrosterone sulfate can predict responsiveness to primary androgen deprivation therapy in patients with metastatic prostate cancer.
Akihiro YANO ; Makoto KAGAWA ; Hideki TAKESHITA ; Yohei OKADA ; Makoto MOROZUMI ; Satoru KAWAKAMI
Asian Journal of Andrology 2019;21(6):635-636