Objective:To explore the genotype and allele distribution feature of cytochrome P450 2C19 (CYP2C19) in Uighur and Han nationality patients With coronary heart disease (CHD).Methods:A total of 355 CHD patients Without kinship,including 194 Uighur cases and 161 Han cases,Were selected. CYP2C19 genetic polymorphism Was analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP),it’ s compared betWeen different age groups (<60 years and≥60 years)of the tWo nationalities.Results:Compared With Han na-tionality patients,there Were significant increase in allele*1 frequency [(64.9% vs.75.2%),P<0.01],signifi-cant decrease in allele*2 (29.5% vs.22.2%),and allele*3 (5.6% vs.2.6%) frequencies (P<0.05 all);geno-type*1/*1 significant increase [(38.5% vs. 57.7%),P<0.01],*1/*2 significant decrease [(44.7% vs. 31.5%),P<0.05],and other four genotype betWeen tWo nationalities Were no significant difference (P>0.05);fast metabolic patter frequency (38.5% vs. 57.7%)significant increase,moderate metabolic patter frequency (52.8% vs. 31.5%)significant decrease (P<0.01 all)in Uighur nationality patients ;In a same nationality,age had no significant impact on its genotype and allele distribution (P>0.05 all).Conclusion:There are significant differences in cytochrome P450 2C19 genotype and allele distribution betWeen Uighur nationality and Han nationali-ty CHD patients,Understanding those is of important significance to guide clinical medication and improve patients' prognosis.

[Objective] To explore the clinical efficacy and feasibility of blue laser transurethral incision of prostate (BLTUIP) in the treatment of small volume (≤30 mL) benign prostatic hyperplasia (BPH). [Methods] The clinical data of 34 BPH patients treated with BLTUIP in the First Affiliated Hospital of Xinjiang Medical University during Mar.and Oct.2023 were retrospectively analyzed.The operation time, 450 nm blue laser light emission time, 980 nm red laser light emission time, postoperative bladder irrigation time, international prostate symptom score (IPSS), quality of life score (QoL), maximum flow rate (Qmax), post-void residual (PVR), international index of erectile function-5 (IIEF-5), ejaculation and incidence of postoperative complications were analyzed. [Results] All operations were successful, without conversion to open or transurethral resection of the prostate (TURP). The operation time was 12.7 (10.8, 14.3) min, the 450 nm blue laser light emission time was 11.7 (9.6, 13.3) min, the 980 nm red laser light emission time was 1.0 (1.0, 2.0) min, the postoperative bladder irrigation time was 5.0 (2.8, 8.0) h, the total hospital stay was 6.0 (4.0, 7.0) d, the postoperative hospital stay was 2.0 (2.0, 3.0) d, and the postoperative catheter retention time was 2.0 (0, 2.0) d. After 3 or 6 months of follow-up, the IPSS, QoL and PVR were significantly lower than those before operation, while the Qmax was significantly higher, with significant differences (P<0.001); but there was no significant difference in the IIEF-5 score (P>0.05). During the 3-month follow-up, 4 patients (11.8%) had fever; during the 3-6 month follow-up, 1 patient (2.9%) had external urethral stricture; of the 8 patients with sexual life before operation, 1 (12.5%) had retrograde ejaculation after operation.No hematuria occurred. [Conclusion] BLTUIP is a new, safe and efficient surgical treatment for BPH with a volume ≤30 mL, which can shorten the operation time, reduce postoperative complications, and improve the quality of life.