Objective To understand the infection status and epidemiological features of individuals entering and exiting the Xinjiang Port so as to provide scientific basis for the prevention and control of AIDS at various ports in China.Methods The data of HIV infection among 291 200 individuals entering and exiting the Xinjiang Port between 2001 and 2007 was analyzed.Results A total of 230 individuals were found infected with HIV and the total infection rate was 0.79‰.The people of prime age(from 20 to 40 years) were the main victims of the infection,the ratio of infection between males and females was 22∶1,and higher rate of infection was seen among the ethnic minority;and traders and drivers were the high risk group.The routes of transmissions differed from region to region,but the mian routes were drug use and sex contact.Conclusion The HIV epidemic in some highly prevalent areas of Xinjiang has not been effectively controlled,and is now being rapidly spread.Therefore,for the control of AIDS transmission at the frontier port it is crucial to strengthen AIDS surveillance among entry-exit personnel,to carry out epidemiological survey,and to disseminate knowledge of AIDS preventioical survey.