1.A novel treatment for weight reduction by the recombinant "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin".
Mahsa JALILI ; Zahra BAZI ; Azita HEKMATDOOST
Journal of Integrative Medicine 2016;14(1):1-4
Obesity is a major health problem across the world, but there are few ways to effectively treat or manage it in the long term. Researchers are searching for more convenient, cost-effective and noninvasive therapies for overweight and obese people. Recent studies have illustrated that the microbiome of the body's different organs can be used as a vehicle for in-situ gene therapy. We suggest that the recombinant form of "Pichia pastoris" yeast expressing the hybrid protein of "irisin-furin-transferrin" under the control of the enolase 1 promoter is a new nutraceutical strategy to absorb fewer calories from intestinal nutrients, and induce a higher metabolic rate to expend more calories, similar to that from engaging in physical activity. By comparison, this method can be a long-term, noninvasive treatment and can be used for obese patients who have movement limitations.
Fibronectins
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genetics
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Furin
;
genetics
;
Genetic Therapy
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Humans
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Obesity
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therapy
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Pichia
;
genetics
;
Recombinant Fusion Proteins
;
genetics
;
Transferrin
;
genetics
;
Weight Loss